Article
Medicine, Research & Experimental
Henry Sackin
Summary: Preexisting hypertension is a known risk factor for severe COVID-19. Abnormal activation of RAS upregulates angiotensin II, contributing to severe manifestations of COVID-19. While RAS inhibitors have been associated with an increase in ACE2 receptors that facilitate cellular entry of the SARS-CoV-2 virus, current medical practice does not recommend curtailing RAS inhibitors. Hypotheses suggest that RAS inhibitors reduce the severity of COVID-19 by promoting ACE2-AT1R complex formation and hindering SARS-CoV-2 binding to ACE2, leading to protocols for reducing disease severity.
MEDICAL HYPOTHESES
(2021)
Review
Pharmacology & Pharmacy
Murtala Bello Abubakar, Dawoud Usman, Gaber El-Saber Batiha, Natalia Cruz-Martins, Ibrahim Malami, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Aliyu Muhammad, Siew Hua Gan, Aliyu Ibrahim Dabai, M. Alblihed, Arabinda Ghosh, Reem H. Badr, Devarajan Thangadurai, Mustapha Umar Imam
Summary: COVID-19 is a potentially fatal multisystemic infection caused by SARS-CoV-2, with a lack of cost-effective, safe, and readily available therapeutic options. Traditional herbs used in African and Asian regions may contribute to a lesser burden of the pandemic. Ethnomedicinal plants containing bioactive compounds could potentially mitigate COVID-19 by modulating ACE2 activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Keiji Kuba, Tomokazu Yamaguchi, Josef M. Penninger
Summary: Seventeen years after the SARS epidemic, the emergence of the novel coronavirus SARS-CoV-2 has led to an unprecedented pandemic. ACE2 plays a crucial role in cell entry of SARS-CoV-2 and its high affinity to ACE2 results in increased infectivity and transmissibility. In addition to serving as the receptor for SARS-CoV-2, ACE2 also plays an important role in various aspects of COVID-19 pathogenesis and potential post-COVID-19 syndromes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alexis Q. Dean, William P. Bozza, Julianne D. Twomey, Shen Luo, Ancy Nalli, Baolin Zhang
Summary: ACE2 plays a dual role in COVID-19, depending on the stage of infection and coexisting diseases in patients.
DRUG DISCOVERY TODAY
(2021)
Review
Medicine, Research & Experimental
Sara Chiappalupi, Laura Salvadori, Aleksandra Vukasinovic, Rosario Donato, Guglielmo Sorci, Francesca Riuzzi
Summary: The novel infectious disease COVID-19, caused by SARS-CoV-2, can lead to severe pneumonia and ARDS in 15% of patients. Research suggests that RAS and RAGE play crucial roles in mediating susceptibility and pathological responses in COVID-19 patients.
Review
Biochemistry & Molecular Biology
Filippo Scialo, Maria Vitale, Aurora Daniele, Ersilia Nigro, Fabio Perrotta, Monica Gelzo, Carlo Iadevaia, Francesco Saverio Cerqua, Adriano Costigliola, Valentino Allocca, Felice Amato, Lucio Pastore, Giuseppe Castaldo, Andrea Bianco
Summary: The COVID-19 pandemic has had a significant impact on socio-economic life, especially posing higher risks for individuals with underlying health conditions. Despite year-long efforts in academic research, there is still much to learn about SARS-CoV-2 and its potential future impacts on human health.
Article
Biochemistry & Molecular Biology
Peiyuan Liu, Yanfeng Zhang, Zibin Li, Jianwen Huang, Tao Wang, Cheng Chen
Summary: This study determined the crystal structure of B38-CAP for the first time, revealing structural conservation features in the M32 family and suggesting that conformational flexibility may play a crucial role in the catalysis of B38-CAP and ACE2. The findings provide a structural basis for further development of B38-CAP-based anti-SARS-CoV-2 drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Subhomoi Borkotoky, Debajit Dey, Zaved Hazarika
Summary: SARS-CoV-2, the virus causing COVID-19, binds to the ACE2 receptor through its spike protein, and mutations in the spike protein may affect vaccine efficacy and neutralizing antibodies. Therefore, understanding the detailed interactions between ACE2 and the spike protein is crucial for preventing virus transmission and therapeutic development.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Chemistry, Medicinal
Enrique Ambrocio-Ortiz, Gloria Perez-Rubio, Alma D. Del Angel-Pablo, Ivette Buendia-Roldan, Leslie Chavez-Galan, Rafael de Jesus Hernandez-Zenteno, Alejandra Ramirez-Venegas, Jorge Rojas-Serrano, Mayra Mejia, Rogelio Perez-Padilla, Cristobal Guadarrama-Perez, Ramces Falfan-Valencia
Summary: ACE2 is a crucial protein involved in various diseases, especially in the infection caused by SARS-CoV-2, playing a significant role in recognizing viral binding proteins.
Article
Medicine, Research & Experimental
Andrea Estefania Portales, Emilio Roman Mustafa, Clara Ines McCarthy, Maria Paula Cornejo, Paula Monserrat Couto, Mariela Mercedes Gironacci, Julio Javier Caramelo, Mario Perello, Jesica Raingo
Summary: This study aimed to investigate the impact of RAS modulators on the susceptibility to SARS-CoV-2 infection and severity of COVID-19. The results showed that the AT1R and B2R receptors modulated the internalization of SARS-CoV-2, and the coexpression of ACE2 affected the inhibitory action of these receptors on calcium channels.
Review
Pharmacology & Pharmacy
Jingwei Bian, Zijian Li
Summary: This article summarizes the complex relationship between the coronavirus, ACE2, and RAS, proposing novel infection modes and pathways for virus entry mediated by ACE2, while also discussing the controversy surrounding the use of anti-RAS drugs.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Medicine, General & Internal
Fabio Angeli, Antonio Spanevello, Gianpaolo Reboldi, Dina Visca, Paolo Verdecchia
Summary: SARS-CoV-2 vaccines can elicit immune responses but concerns about cardiovascular adverse reactions have been raised. Vaccines can increase Spike protein synthesis and immune responses, with genetic and immunological factors possibly impacting reactions.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Antonio Vitiello, Francesco Ferrara
Summary: The new SARS-CoV-2 coronavirus enters host cells through ACE2, and the expression of ACE2 undergoes changes during different stages of COVID-19 infection, which may be related to severe lung damage. Modifying the expression of ACE2 pharmacologically could be an interesting research direction to avoid severe complications of COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Geriatrics & Gerontology
Veronica Galvan, Jorge Quarleri
Article
Microbiology
Paula Constanza Arriola Benitez, Ayelen Ivana Pesce Viglietti, Maria Mercedes Elizalde, Guillermo Hernan Giambartolomei, Jorge Fabian Quarleri, Maria Victoria Delpino
Review
Biochemistry & Molecular Biology
Jorge Quarleri, M. Victoria Delpino
Summary: Research has shown that SARS-CoV-2 infection can lead to different patterns of disease progression, with interferon playing a key role in the process. The effectiveness of IFN and its role in disease outcomes are influenced by both viral and host factors.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Letter
Immunology
Jorge Quarleri, Cintia Cevallos, M. Victoria Delpino
IMMUNOLOGY LETTERS
(2021)
Article
Cell Biology
Virginia Vanasco, Alejandro Ropolo, Daniel Grasso, Diego S. Ojeda, Maria Noe Garcia, Tamara A. Vico, Tamara Orquera, Jorge Quarleri, Silvia Alvarez, Maria I. Vaccaro
Summary: Mitophagy and zymophagy are selective autophagy pathways induced in acute pancreatitis, with mitochondrial dysfunction and changes in mitochondrial dynamics observed. A novel DRP1-Parkin1-VMP1 selective autophagy pathway was identified during acute pancreatitis, mediating the selective degradation of damaged mitochondria and providing insights for potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Maria Mercedes Elizalde, Luciana Tadey, Lilia Mammana, Jorge Fabian Quarleri, Rodolfo Hector Campos, Diego Martin Flichman
Summary: This study provides new insights into the biological characteristics of HBV genotypes, showing significant differences in replication capacity and antigen expression among different genotypes. Understanding these differences may help to elucidate the differential role of genotypes in the pathogenesis of HBV.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Ayelen Ivana Pesce Viglietti, Franco Agustin Sviercz, Cinthya Alicia Marcela Lopez, Rosa Nicole Freiberger, Jorge Quarleri, Maria Victoria Delpino
Summary: Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children aged 6 to 48 months. Infection with K. kingae directly stimulates osteoclastogenesis and indirectly through a potent pro-inflammatory response that drives macrophages to become functional osteoclasts. Additionally, the osteoclastogenic capability of K. kingae is counteracted by their outer membrane vesicles in a concentration-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Geriatrics & Gerontology
Jorge Quarleri, Veronica Galvan, M. Victoria Delpino
Editorial Material
Geriatrics & Gerontology
Veronica Galvan, Jorge Quarleri
Summary: Comparative study between Sinopharm and BNT162b2 vaccines showed differences in the immune responses against SARS-CoV-2 virus, indicating the importance of analyzing adaptive immunity generated by different vaccine platforms in the fight against COVID-19.
Review
Geriatrics & Gerontology
Jorge Quarleri, M. Victoria Delpino
Summary: This article explores the potential role of disturbances in the renin-angiotensin system (RAS) as a cause for central nervous system sequelae of SARS-CoV-2 infection in elderly patients.
Article
Geriatrics & Gerontology
Jorge Quarleri, M. Victoria Delpino, Veronica Galvan
Summary: The neglected and rare zoonotic disease caused by monkeypox virus (MPV) has recently spread widely, resulting in the largest known monkeypox outbreak outside of Africa. MPV is transmitted directly by either person-to-person, -animal, or virus-contaminated fomite contact, with symptoms including fever, skin lesions, and lymphadenopathies. No deaths have been associated with the current outbreak, and diagnosis with molecular techniques is recommended, with vaccines and drugs available for immunity to MPV.
Article
Biochemistry & Molecular Biology
Cintia Cevallos, Diego S. Ojeda, Lautaro Sanchez, Javier Urquiza, Maria Victoria Delpino, Jorge Quarleri
Summary: HIV infection can result in the death of astrocytes through cell-to-cell contact with infected cells, while the infected astrocytes can counteract this death signal and spread the contagious bystander cell death to neighboring uninfected cells.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Jorge Quarleri, Veronica Galvan, M. Victoria Delpino
Summary: This article provides an overview of the pathogenicity of Nipah virus and Hendra virus, as well as their interaction with the human immune system. Given their high pathogenicity and ability to spread, the diseases caused by these viruses require close attention.
Review
Geriatrics & Gerontology
Jorge Quarleri
Summary: The World Health Organization Western Pacific Region has been free of polio for over 20 years, but two challenges remain. Firstly, elderly polio survivors experience late polio sequelae that greatly affect their daily lives and quality of life. Secondly, vaccine-derived poliovirus strains are circulating and pose a significant obstacle to polio elimination. Maintaining high vaccination rates and improving living conditions in poorer nations are crucial for eradicating polio.
