Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19

Antihypertensive Drugs and COVID-19 Risk

(2021) Laura Semenzato et al.   HYPERTENSION

A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

(2021) Jan Wysocki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions

(2021) Chandrika Bhattacharyya et al.   INFECTION GENETICS AND EVOLUTION

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

(2021) Michel Thépaut et al.   PLoS Pathogens

ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

(2021) Tomokazu Yamaguchi et al.   Nature Communications

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

(2020) Takafumi Minato et al.   Nature Communications

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

(2020) Kui K. Chan et al.   SCIENCE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Human recombinant soluble ACE2 in severe COVID-19

(2020) Alexander Zoufaly et al.   Lancet Respiratory Medicine

miRNA-200c-3p is crucial in acute respiratory distress syndrome

(2017) Qiang Liu et al.   Cell Discovery

Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases

(2013) Keiji Kuba et al.   CIRCULATION JOURNAL

Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain

(2010) Sandrine Belouzard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

(2010) Keiji Kuba et al.   PHARMACOLOGY & THERAPEUTICS