Article
Nanoscience & Nanotechnology
Wenyu Song, Xiao Zhang, Yangmeihui Song, Kevin Fan, Fuqiang Shao, Yu Long, Yu Gao, Weibo Cai, Xiaoli Lan
Summary: An in situ self-assembly strategy has been developed to enhance the photothermal therapy of glioblastomas. The strategy utilizes a glutathione-reactive self-assembling polypeptide as a skeleton, with indocyanine green (ICG) as a theranostic agent and cyclic Arg-Gly-Asp [c(RGD)fk] peptides as the targeting group. This strategy provides clearer tumor imaging, prolongs the tumor retention time of the therapeutic agent, and significantly suppresses glioblastoma growth.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Indika Chandrasiri, Mahesh Loku Yaddehige, Bo Li, Yuzhe Sun, William E. Meador, Austin Dorris, Mohammad Farid Zia, Nathan Hammer, Alex Flynt, Jared H. Delcamp, Edward Davis, Alexander Lippert, Davita L. Watkins
Summary: This study compares the solution behavior and self-assembly pattern of two linear dendritic block copolymers (LDBCs) and finds that the introduction of phenyl substituents improves the stability and loading efficiency of LDBC nanoparticles, which shows great potential for use as nanocarriers in therapeutic nanomedicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Leihao Lu, Qing Bao, Yao Miao, Qichao Cheng, Yuyin Chen, Shuxu Yang, Chuanbin Mao, Mingying Yang
Summary: Thrombotic disease is a serious health threat that requires targeted therapy and precise thrombus localization. A nanoparticle called Mp-Bi@SiO2-GK has been developed to address the limitations of traditional drugs. It combines thrombus targeting, computed tomography (CT) imaging, photothermal therapy, and chemotherapy to enhance thrombolysis efficiency without harming tissues or affecting organ metabolism.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yaling He, Muhammad Rizwan Younis, Chao Jiang, Gang He, Jin He, Yinling Zhang, Hengke Liu, Peng Huang, Jing Lin
Summary: Gas therapy using self-assembled gold nanovesicles loaded with ammonium sulfide has shown great promise for precision cancer theranostics. These nanovesicles can generate hydrogen sulfide in situ under near-infrared activation, leading to tumor cell killing. The nanovesicles exhibit high encapsulation efficiency and photothermal effect, resulting in effective tumor ablation in vivo.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Wenteng Xie, Yuehao Gan, Lulu Wang, Yuanchun Si, Qingdong Li, Tianwei Song, Pengfei Wei, Zhengyan Wu, Guilong Zhang
Summary: In this study, a tumor microenvironment-responsive core-shell nanozyme was developed, which exhibited high antitumor activity and specific targeting to tumor cells. The nanozyme had dual contrast imaging capabilities and induced cancer cell apoptosis and ferroptosis. It also showed potential for combined photothermal therapy, ferroptosis therapy, and chemodynamic therapy.
Review
Biochemistry & Molecular Biology
Nandan Gupta, Rishabha Malviya
Summary: The use of gold nanoparticles in photothermal therapy for cancer treatment is highlighted in this communication, showing their potential in warning cancer cells to other therapies, modulating cellular permeability and delivery, and achieving effective therapy management.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Engineering, Biomedical
Mengxin Wang, Xue Zhang, Qian Chang, Haifeng Zhang, Zhenbo Zhang, Kailin Li, Hui Liu, Donglin Liu, Lu An, Qiwei Tian
Summary: The misdiagnosis of tumors and damage to normal tissues are the main challenges in using photothermal agents for clinical translation. To overcome these limitations, a strategy of switching to the NIR-II region based on tumor microenvironment (TME)-mediated gold self-assembly was developed. The use of TME-activated NIR-II photothermal agents allows for accurate tumor diagnosis and inhibition of tumor growth.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Rong Zhu, Juan Li, Lisen Lin, Jibin Song, Huanghao Yang
Summary: Plasmonic gold nanocrystals exhibit unique optical enhancement, catalytic activity, and photothermal properties, and when combined with DNA technology, novel functional Au nanomaterials can be created for biosensing, imaging, drug delivery, and therapy applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Atieh Jahangiri-Manesh, Marziyeh Mousazadeh, Shirinsadat Taji, Abbas Bahmani, Atefeh Zarepour, Ali Zarrabi, Esmaeel Sharifi, Mostafa Azimzadeh
Summary: This review provides a comprehensive overview of the properties, synthesis methods, toxicity, and therapeutic applications of gold nanorods. Gold nanorods have unique physical, optical, and chemical properties that make them suitable for various biomedical applications, including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. The review discusses the potential, challenges, and future perspectives of gold nanorods in the field of biomedicine.
Article
Multidisciplinary Sciences
Zhe Feng, Yuanyuan Li, Siyi Chen, Jin Li, Tianxiang Wu, Yanyun Ying, Junyan Zheng, Yuhuang Zhang, Jianquan Zhang, Xiaoxiao Fan, Xiaoming Yu, Dan Zhang, Ben Zhong Tang, Jun Qian
Summary: The authors developed NIR-II fluorescent small molecules with high brightness and emission extending to 1900 nm, enabling high-contrast fluorescence imaging of deep tissues in vivo.
NATURE COMMUNICATIONS
(2023)
Article
Thermodynamics
Dingzhang You, Ting Chen, Guohua Liu
Summary: This study introduces a tumor computational model that combines the physical properties of plasmonic resonance and photothermal conversion with the biological characteristics of tumor growth and treatment response. The results indicate that 140 nm nanorods exhibit the best therapeutic performance and are significantly enhanced under the influence of collective effects.
THERMAL SCIENCE AND ENGINEERING PROGRESS
(2023)
Article
Chemistry, Analytical
Yan Tan, Jianxing Zhou, Xiaotong Xing, Junren Wang, Jinkun Huang, Huiyu Liu, Jiajie Chen, Mingjie Dong, Qin Xiang, Haifeng Dong, Xueji Zhang
Summary: In this study, the controllable self-assembly of DNA-linked gold nanoparticles (AuNPs) for in vivo biomedical applications was achieved by using programmable DNA tetrahedral structures. Three different sizes of AuNPs (20nm, 10nm, and 5nm) were organized and positioned using this method. The density and arrangement of the satellite AuNPs around the core AuNPs were controlled by tuning the size and amount of DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement. With the conjugation of Raman molecules, strong surface-enhanced Raman scattering photoacoustic imaging signals were generated, allowing for the imaging of microRNA-21 and tumor tissues in vivo. This study provides an efficient strategy for building precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Aleksandra Pilch-Wrobel, Lukasz Marciniak, P. James Schuck, Artur Bednarkiewicz
Summary: Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Cristina de la Encarnacion, Dorleta Jimenez de Aberasturi, Luis M. Liz-Marzan
Summary: Multicompartment nanoparticles combining magnetic and plasmonic components have shown great potential for biomedical applications, including multimodal bioimaging, hyperthermal therapies, and magnetically driven selective delivery. Iron oxide and gold nanoparticles are commonly used due to their size-dependent properties, biocompatibility, and tunable physical and chemical characteristics. This review provides an overview of recent synthetic protocols for preparing magnetic-plasmonic nanostructures and discusses the progress made in multifunctional bioimaging and heating-based therapies, highlighting the advantages and limitations of different systems.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Xinyu Qu, Yixing Chen, Zhuyun Cai, Xinyu Zhao, Hua Zeng, Xiaohao Liu, Shuo Tan, Bingqiang Lu, Rui Gao, Feng Chen
Summary: A collagen-induced self-assembled gold photosensitizer has been synthesized using adenosine monophosphate (AMP) modified gold nanoparticles (AAu NPs), which can enhance the accumulation and retention of the photosensitizer within tumor tissue for efficient photothermal therapy.
CANCER NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yutao Zhang, Chenxu Yan, Qiaoqiao Zheng, Qian Jia, Zhongliang Wang, Ping Shi, Zhiqian Guo
Summary: Researchers have developed a hypoxia-dependent photoactivation mechanism for precise manipulation of biological events and in vivo feedback regulation. This novel approach overcomes the limitation of oxygen-dependence in current near-infrared photocages, expanding the toolbox for targeted therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Xianghan Zhang, Sumei Zhao, Zhiqing Gao, Jialin Zhou, Yuqiong Xia, Jie Tian, Changhong Shi, Zhongliang Wang
Summary: Cancer phototheranostics using mitochondria-targeted NIR cyanines encapsulated in liposomal bilayers showed promising results in balancing hydrophilicity and hydrophobicity, as well as improving tumor cell uptake through a bioorthogonal-mediated targeting strategy. The CyBI7-LPB probe exhibited excellent tumor targeting and anti-tumor therapy outcomes in experimental settings.
Review
Engineering, Biomedical
Peng Yang, Zhuang Chen, Shaojie Liu, Chaoqiang Qiao, Yuqiong Xia, Zhongliang Wang
Summary: This review summarizes the research progress in designing DDS and CTA using metal-organic frameworks (MOF), showing the simplicity, control, and versatility of these materials for cancer treatment and providing prospects for the development of MOF-based nanomedicine in the future.
BIOMEDICAL MATERIALS
(2021)
Article
Oncology
Jia Ran, Ran Cao, Jiumei Cai, Tao Yu, Dan Zhao, Zhongliang Wang
Summary: This study developed and validated a prediction model based on radiomics signature, deep learning signature, and CT-reported LN status for predicting preoperative LN metastasis in patients with LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chaoqiang Qiao, Xiaofei Wang, Guohuan Liu, Zuo Yang, Qian Jia, Lexuan Wang, Ruili Zhang, Yuqiong Xia, Zhongliang Wang, Yang Yang
Summary: A biomimetic metal-organic framework nanodrug, camouflaged with erythrocyte membrane, demonstrates efficient accumulation and penetration in tumor tissues, while releasing drugs to deplete collagen and increase oxygen supply for enhanced chemotherapy outcomes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hongzhang Deng, Zuo Yang, Xiaoyu Pang, Caiyan Zhao, Jie Tian, Zhongliang Wang, Xiaoyuan Chen
Summary: This study prepared a series of nanoparticles with tunable acid dissociation constant, successfully enhancing the efficacy of CDT in cancer treatment by converting H2O2 into highly toxic hydroxyl radical to kill tumor cells and avoiding clearance by cytoplasmic antioxidants.
Article
Chemistry, Multidisciplinary
Jie Yu, Hua Xiao, Zuo Yang, Chaoqiang Qiao, Bin Zhou, Qian Jia, Zhongdi Wang, Xiaofei Wang, Ruili Zhang, Yang Yang, Zhongliang Wang, Jianxiong Li
Summary: The excessive production of glutathione (GSH) by tumor cells hinders the efficacy of photodynamic therapy and chemotherapy. A novel GSH-inhibiting nanosystem (PCNPs) is reported here for persistent synergistic cancer therapy, offering sustained suppression of GSH biosynthesis and improved drug utilization. The PCNPs also act as efficient singlet oxygen radical generators, enhancing photodynamic therapy.
Article
Multidisciplinary Sciences
Qian Jia, Ruili Zhang, Yongdong Wang, Haohao Yan, Zheng Li, Yanbin Feng, Yu Ji, Zuo Yang, Yang Yang, Kanyi Pu, Zhongliang Wang
Summary: Dysregulated energy metabolism is recognized as a characteristic of cancer. A newly developed fluorescent probe, MACaP9, shows specific response to the acidic tumor environment and converts pH variations into a fluorescence signal, enabling visualization and distinction of tumor from normal tissues.
Article
Multidisciplinary Sciences
Shaohua Qu, Qian Jia, Zheng Li, Zhongliang Wang, Li Shang
Summary: This study synthesized chiral NIR-II fluorescent nanoprobes and investigated the relationship between their chirality and biological functions. The results showed that chirality determined the interaction with serum proteins, cellular uptake efficiency, as well as the localization and elimination in vivo. Engineering the surface chirality of nanoprobes can enhance their targeting capabilities.
Article
Chemistry, Multidisciplinary
Jie Yu, Ruili Zhang, Baihang Chen, Xuelan Liu, Qian Jia, Xiaofei Wang, Zuo Yang, Pengbo Ning, Zhongliang Wang, Yang Yang
Summary: This study establishes a system consisting of a degradable hydrogel dressing that reacts to reactive oxygen species, an encapsulated biosafe nitric oxide donor, and a low concentration of hydrogen peroxide as a disinfectant. This system promotes sustainable wound healing and disinfection by generating nitric oxide and mediating cell migration and collagen synthesis. It also demonstrates synergistic antibacterial properties against antibiotic-resistant bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Xianghan Zhang, Jingkai Gao, Yingdi Tang, Jie Yu, Si Si Liew, Chaoqiang Qiao, Yutian Cao, Guohuan Liu, Hongyu Fan, Yuqiong Xia, Jie Tian, Kanyi Pu, Zhongliang Wang
Summary: This article presents a method for expanding the repertoire of responsive dyes in biorthogonal chemistry by developing a near-infrared fluorophore that turns on its fluorescence upon biorthogonal reaction. The study discovers a design mechanism for the construction of bioorthogonally activatable NIR fluorophores and demonstrates their potential in sensitive in vivo imaging of tumors.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qian Jia, Ruili Zhang, Haohao Yan, Yanbin Feng, Fang Sun, Zuo Yang, Chaoqiang Qiao, Xiaocheng Mou, Jie Tian, Zhongliang Wang
Summary: Accurate detection of lung metastasis is crucial for cancer treatment and prognosis, but remains challenging in clinical practice. This study presents a strategy to develop a pH-activatable near-infrared fluorescent nanoprobe for precise identification of lung cancer and pulmonary metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Zhiguo Fang, Chenlei Wang, Jingrun Yang, Zhizheng Song, Chunyu Xie, Yu Ji, Zhongliang Wang, Xiaohui Du, Qiang Zheng, Chunying Chen, Zhiyuan Hu, Yeteng Zhong
Summary: A non-invasive in vivo sO2 imaging technique based on photoluminescence bioimaging in the NIR-IIb window allows for the visualization of sO2 levels in healthy and tumor tissue. Real-time dynamic sO2 imaging reveals cerebral arteries and veins and is consistent with haemodynamic analysis. Tumor-associated vessel sO2 levels can be evaluated using this technique.
NATURE NANOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Zhiping Rao, Yutong Zhu, Peng Yang, Zhuang Chen, Yuqiong Xia, Chaoqiang Qiao, Weijing Liu, Hongzhang Deng, Jianxiong Li, Pengbo Ning, Zhongliang Wang
Summary: Pyroptosis is a critical type of programmed cell death that plays a key role in host defense against pathogen infection and can serve as a new strategy for cancer elimination. Excessive pyroptosis, however, may lead to inflammatory diseases. Therefore, it is important to fully understand the molecular mechanisms and therapeutic implications of pyroptosis.
Article
Medicine, Research & Experimental
Qian Jia, Zheng Li, Mingli Bai, Haohao Yan, Ruili Zhang, Yu Ji, Yanbin Feng, Zuo Yang, Zhongliang Wang, Jianxiong Li
Summary: Er-DCNPs with high temporal-spatial resolution in the NIR-IIb imaging window can visualize anatomical and pathophysiological features of the mouse vasculature, provide dynamic information on blood perfusion, and achieve the synergistic integration of diagnostic and therapeutic imaging functions, which is meaningful for the successful management of PAD.