期刊
NANO RESEARCH
卷 14, 期 7, 页码 2432-2440出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-3246-2
关键词
cancer phototheranostics; NIR cyanine; liposome; mitochondria-targeted; phototherapy
类别
资金
- National Key Research and Development Program of China [2017YFC1309100, 2017YFA0205200]
- National Natural Science Foundation of China [81671753, 91959124, 81227901, 21804104]
- Natural Science Foundation of Shaanxi Province of China [2020PT-020]
- Key Research and Development Program of Shaanxi Province [2019NY-085]
- Natural Science Basic Research Program of Shaanxi Province of China [2019JQ-139, 2019JQ-662, 2018JM2041]
- Fundamental Research Funds for the Central Universities [JB191211, JB191207, JB191208]
- Open Project Program of the State Key Laboratory of Cancer Biology (Fourth Military Medical University) [CBSKL2019ZDKF06]
Cancer phototheranostics using mitochondria-targeted NIR cyanines encapsulated in liposomal bilayers showed promising results in balancing hydrophilicity and hydrophobicity, as well as improving tumor cell uptake through a bioorthogonal-mediated targeting strategy. The CyBI7-LPB probe exhibited excellent tumor targeting and anti-tumor therapy outcomes in experimental settings.
Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PIT) is a localized noninvasive approach in treating cancer. Mitochondria-targeted near-infrared (NIR) cyanines are excellent therapeutic photosensitizers of cancer. However, most mitochondria-targeted cyanines exist in the form of hydrophobic structures, which in vivo may cause cyanine aggregation during blood circulation, resulting in poor biocompatibility and limited therapeutic efficacy. Therefore, we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers (CyBI7-LPs), which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting. Moreover, CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species (ROS) could rapidly escape from the liposomal bilayer, affording enhanced PTT/PDT efficacy. Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyB17-LPB. The CyBI7-LPB probe produced a tumor-to-background ratio (TBR) of approximately 6.4 at 24 HPI. Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects. This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据