Ethanol exposure increases mutation rate through error-prone polymerases

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

(2019) Yuina Sonohara et al.   Scientific Reports

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

(2018) Angela M Wood et al.   LANCET

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

(2018) Alba Duch et al.   Nature Communications

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

(2018) Juan I. Garaycoechea et al.   NATURE

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

rSalvador: An R Package for the Fluctuation Experiment

(2017) Qi Zheng   G3-Genes Genomes Genetics

A shifting mutational landscape in 6 nutritional states: Stress-induced mutagenesis as a series of distinct stress input–mutation output relationships

(2017) Ram P. Maharjan et al.   PLOS BIOLOGY

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global analysis of genomic instability caused by DNA replication stress inSaccharomyces cerevisiae

(2016) Dao-Qiong Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer incidence and mortality attributable to alcohol consumption

(2015) Delphine Praud et al.   INTERNATIONAL JOURNAL OF CANCER

Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage

(2015) David van Dijk et al.   Nature Communications

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

(2015) Irene Gallina et al.   Nature Communications

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

(2015) Olga V. Kochenova et al.   PLoS Genetics

Adaptation to High Ethanol Reveals Complex Evolutionary Pathways

(2015) Karin Voordeckers et al.   PLoS Genetics

Environmentally responsive genome-wide accumulation of de novoArabidopsis thalianamutations and epimutations

(2014) Caifu Jiang et al.   GENOME RESEARCH

Molecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments

(2014) Jungeui Hong et al.   PLoS Genetics

Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis

(2013) Philip J. Brooks et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae

(2013) S. Boiteux et al.   GENETICS

Replacement of the Saccharomyces cerevisiae acetyl-CoA synthetases by alternative pathways for cytosolic acetyl-CoA synthesis

(2013) Barbara U. Kozak et al.   METABOLIC ENGINEERING

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Evaluating evolutionary models of stress-induced mutagenesis in bacteria

(2013) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

(2013) A. Gutierrez et al.   Nature Communications

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

(2013) Erika Shor et al.   PLoS Genetics

Environmental Stresses Disrupt Telomere Length Homeostasis

(2013) Gal Hagit Romano et al.   PLoS Genetics

Overexpression of PDE2 or SSD1-V in Saccharomyces cerevisiae W303-1A strain renders it ethanol-tolerant

(2012) Liat Avrahami-Moyal et al.   FEMS YEAST RESEARCH

Ethanol Suppresses Ureagenesis in Rat Hepatocytes

(2012) Ekhson L. Holmuhamedov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

(2012) Guangbo Chen et al.   NATURE

Coordinated control of replication and transcription by a SAPK protects genomic integrity

(2012) Alba Duch et al.   NATURE

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans

(2011) A. Forche et al.   mBio

DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase

(2010) M. Brendel et al.   GENETICS AND MOLECULAR RESEARCH

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast

(2009) V. Pages et al.   GENES & DEVELOPMENT

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Estimating the Per-Base-Pair Mutation Rate in the Yeast Saccharomyces cerevisiae

(2008) Gregory I. Lang et al.   GENETICS

Claspin Promotes Normal Replication Fork Rates in Human Cells

(2008) Eva Petermann et al.   MOLECULAR BIOLOGY OF THE CELL

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide view of the spectrum of spontaneous mutations in yeast

(2008) M. Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA