Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

(2013) S. L. Poon et al.   Science Translational Medicine

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

(2013) M. L. Hoang et al.   Science Translational Medicine

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

Kinetics of DNA Adduct Formation in the Oral Cavity after Drinking Alcohol

(2012) S. Balbo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair

(2012) N. Kotova et al.   CARCINOGENESIS

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

Alcohol Metabolism in Human Cells Causes DNA Damage and Activates the Fanconi Anemia-Breast Cancer Susceptibility (FA-BRCA) DNA Damage Response Network

(2011) Jessy Abraham et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

[13C2]- Acetaldehyde Promotes Unequivocal Formation of 1,N2-Propano-2′-deoxyguanosine in Human Cells

(2011) Camila Carrião M. Garcia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Towards systematic functional characterization of cancer genomes

(2011) Jesse S. Boehm et al.   NATURE REVIEWS GENETICS

Application of LC–TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients

(2010) Stefan W. Toennes et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Volatile Flavor Compounds in Yogurt: A Review

(2010) Hefa Cheng   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Next-generation sequencing: emerging lessons on the origins of human cancer

(2010) Gerd P Pfeifer et al.   CURRENT OPINION IN ONCOLOGY

Bypass of N2-ethylguanine by human DNA polymerase κ☆

(2010) Matthew G. Pence et al.   DNA REPAIR

Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions

(2010) Gunda Millonig et al.   INTERNATIONAL JOURNAL OF CANCER

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

(2010) William Lee et al.   NATURE

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

(2010) Samantha Perez-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemistry and Biology of DNA Containing 1,N2-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal

(2009) Irina G. Minko et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease

(2009) Ying Wang et al.   HEPATOLOGY

A review of human carcinogens—Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish

(2009) Béatrice Secretan et al.   LANCET ONCOLOGY

Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: Implications for alcohol-related carcinogenesis

(2009) Cheryl Marietta et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights

(2009) Larry H. Thompson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Fanconi anemia and its diagnosis

(2009) Arleen D. Auerbach   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chloroacetaldehyde-induced mutagenesis in Escherichia coli: The role of AlkB protein in repair of 3,N4-ethenocytosine and 3,N4-α-hydroxyethanocytosine

(2009) Agnieszka M. Maciejewska et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

(2009) K. Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

(2009) Philip J Brooks et al.   PLOS MEDICINE

N2-Ethyldeoxyguanosine as a Potential Biomarker for Assessing Effects of Alcohol Consumption on DNA

(2008) S. Balbo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function

(2008) Blythe D. Shepard et al.   HEPATOLOGY

Lesion Bypass ofN2-Ethylguanine by Human DNA Polymerase ι

(2008) Matthew G. Pence et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Blocking Effects of the Acetaldehyde-derived DNA LesionN2-Ethyl-2′-deoxyguanosine on Transcription by Multisubunit and Single Subunit RNA Polymerases

(2008) Tsu-Fan Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Analysis of Translesion Synthesis Opposite BulkyN2- andO6-Alkylguanine DNA Adducts by Human DNA Polymerase REV1

(2008) Jeong-Yun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

(2008) Peter J Campbell et al.   NATURE GENETICS

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast)

(2007) Vincent Paget et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS