标题
Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 30, Pages 17747-17756
出版商
Proceedings of the National Academy of Sciences
发表日期
2020-07-16
DOI
10.1073/pnas.2006231117
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
- (2019) Thomas C. R. Miller et al. NATURE
- Mechanisms of replication origin licensing: a structural perspective
- (2019) Franziska Bleichert CURRENT OPINION IN STRUCTURAL BIOLOGY
- Conformational control and DNA-binding mechanism of the metazoan origin recognition complex
- (2018) Franziska Bleichert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the origin recognition complex bound to DNA replication origin
- (2018) Ningning Li et al. NATURE
- Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
- (2017) Yuanliang Zhai et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
- (2017) Simina Ticau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1
- (2017) Zuanning Yuan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model
- (2017) Yasunori Noguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading
- (2017) Gideon Coster et al. SCIENCE
- Cryo-EM structure of a licensed DNA replication origin
- (2017) Ferdos Abid Ali et al. Nature Communications
- Cdt1 stabilizes an open MCM ring for helicase loading
- (2017) Jordi Frigola et al. Nature Communications
- Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
- (2017) Yuanliang Zhai et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
- (2017) Simina Ticau et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1
- (2017) Zuanning Yuan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure of the active form of human origin recognition complex and its ATPase motor module
- (2017) Ante Tocilj et al. eLife
- Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading
- (2015) Simina Ticau et al. CELL
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Semi-automated selection of cryo-EM particles in RELION-1.3
- (2015) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Structure of the eukaryotic MCM complex at 3.8 Å
- (2015) Ningning Li et al. NATURE
- Crystal structure of the eukaryotic origin recognition complex
- (2015) Franziska Bleichert et al. NATURE
- Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues
- (2015) Hironori Kawakami et al. Scientific Reports
- Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function
- (2014) Jingchuan Sun et al. GENES & DEVELOPMENT
- Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes
- (2014) Min Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation
- (2014) Sukhyun Kang et al. MOLECULAR CELL
- Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase
- (2014) Gideon Coster et al. MOLECULAR CELL
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly
- (2013) Alejandra Fernández-Cid et al. MOLECULAR CELL
- ATPase-dependent quality control of DNA replication origin licensing
- (2013) Jordi Frigola et al. NATURE
- Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
- (2013) Xueming Li et al. NATURE METHODS
- Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA
- (2013) Jingchuan Sun et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization
- (2013) C. Evrin et al. NUCLEIC ACIDS RESEARCH
- A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
- (2013) Franziska Bleichert et al. eLife
- ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote
- (2012) Artem Y. Lyubimov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells
- (2011) Jingjing Zhang et al. CELL CYCLE
- The structural basis for MCM2–7 helicase activation by GINS and Cdc45
- (2011) Alessandro Costa et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural insights into the Cdt1-mediated MCM2–7 chromatin loading
- (2011) Changdong Liu et al. NUCLEIC ACIDS RESEARCH
- Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB
- (2011) S. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Characterization and Structure Determination of the Cdt1 Binding Domain of Human Minichromosome Maintenance (Mcm) 6
- (2010) Zhun Wei et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing
- (2009) Dirk Remus et al. CELL
- Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography
- (2009) Leonardo G. Trabuco et al. METHODS
- A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
- (2009) C. Evrin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The origin recognition complex protein family
- (2009) Bernard P Duncker et al. GENOME BIOLOGY
- Finding Transition Pathways Using the String Method with Swarms of Trajectories
- (2008) Albert C. Pan et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae
- (2008) Z. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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