OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

(2019) Paul Petrus et al.   Cell Metabolism

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

Innate immune cells in the adipose tissue

(2018) Kyoung-Jin Chung et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

(2018) Yajing Chu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes

(2018) Roselle Gélinas et al.   Frontiers in Endocrinology

Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation

(2018) Ji-Sun Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation

(2017) Hai-Bin Ruan et al.   GENES & DEVELOPMENT

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

(2017) Benjamin A. Olenchock et al.   IMMUNITY

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage functions in lean and obese adipose tissue

(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

Metabolism Supports Macrophage Activation

(2017) P. Kent Langston et al.   Frontiers in Immunology

Adipocyte lipolysis and insulin resistance

(2016) Pauline Morigny et al.   BIOCHIMIE

New insights: A role for O-GlcNAcylation in diabetic complications

(2016) Sherket B. Peterson et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nutrient regulation of gene expression by O-GlcNAcylation of chromatin

(2016) Stéphan Hardivillé et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling

(2016) Mingzuo Jiang et al.   Oncotarget

Functional Plasticity of Adipose-Derived Stromal Cells During Development of Obesity

(2016) Xiang-Yang Zhu et al.   Stem Cells Translational Medicine

Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis

(2015) Ryan W. Grant et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Data-driven encoding for quantitative genetic trait prediction

(2015) Dan He et al.   BMC BIOINFORMATICS

O-GlcNAc signaling in cancer metabolism and epigenetics

(2015) Jay Prakash Singh et al.   CANCER LETTERS

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

You are what you eat

(2015) Stéphanie Olivier-Van Stichelen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice

(2015) Gabriele Schoiswohl et al.   ENDOCRINOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

The role of fatty acids in insulin resistance

(2015) Barry Sears et al.   Lipids in Health and Disease

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

(2015) V. L. Sodi et al.   MOLECULAR CANCER RESEARCH

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro

(2014) Paola Italiani et al.   PLoS One

HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages

(2014) Bing Yan et al.   PLoS One

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

O-GlcNAcylation of kinases

(2012) Wagner B. Dias et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells

(2011) Howard Goldberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response

(2011) In-Hyun Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

(2011) Jia Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats

(2010) Cornelio Barrientos et al.   NUTRITION RESEARCH

MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4himonocytes in obesity

(2009) Daniel J. Westcott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of p53 enhances catalytic activity of IKK  through O-linked  -N-acetyl glucosamine modification

(2009) K. Kawauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE