cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

(2020) Elisa Zuccarello et al.   BIOCHEMICAL PHARMACOLOGY

Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation

(2020) Galen A. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

(2019) Hanming Zhang et al.   Science Advances

Large-scale Discovery of Substrates of the Human Kinome

(2019) Naoyuki Sugiyama et al.   Scientific Reports

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

(2019) George S. Baillie et al.   NATURE REVIEWS DRUG DISCOVERY

Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function

(2019) Xiaoyan Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

(2018) Sourav Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline

(2018) Ari W. Schaler et al.   Translational Research

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity

(2018) Keqi Fan et al.   JOURNAL OF AUTOIMMUNITY

Regulation of proteasome assembly and activity in health and disease

(2018) Adrien Rousseau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impairment of protein degradation and proteasome function in hereditary neuropathies

(2017) Jordan J. S. VerPlank et al.   GLIA

Proteasome dysfunction in cardiomyopathies

(2017) Jennifer E. Gilda et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression

(2017) Raphael Hesse et al.   Alzheimers Research & Therapy

New Pharmacological Strategies to Increase cGMP

(2016) Alessia Buglioni et al.   Annual Review of Medicine

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Muscle wasting in disease: molecular mechanisms and promising therapies

(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Decreased levels of guanosine 3′, 5′-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

(2015) Ana Ugarte et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

(2014) Mark J. Ranek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

(2014) Maria Stella Ritorto et al.   Nature Communications

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Rpt6 Regulates Synaptic Strength in Hippocampal Neurons

(2012) S. N. Djakovic et al.   JOURNAL OF NEUROSCIENCE

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

Phosphodiesterases and cardiac cGMP: evolving roles and controversies

(2011) Manling Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ASK1 Negatively Regulates the 26 S Proteasome

(2010) Ji Won Um et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmotic Stress Inhibits Proteasome by p38 MAPK-dependent Phosphorylation

(2010) Seung-Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY