A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

(2019) Katrin Mestermann et al.   Science Translational Medicine

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Stargardt macular dystrophy and evolving therapies

(2018) Rehan M. Hussain et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Increased plasma RBP4 concentration in older hypertensives is related to the decreased kidney function and the number of antihypertensive drugs—results from the PolSenior substudy

(2017) Marcin Majerczyk et al.   Journal of the American Society of Hypertension

Human antibody-based chemically induced dimerizers for cell therapeutic applications

(2017) Zachary B Hill et al.   Nature Chemical Biology

Chimeric antigen receptor T-cell therapy — assessment and management of toxicities

(2017) Sattva S. Neelapu et al.   Nature Reviews Clinical Oncology

CNS Endothelial Cell Activation Emerges as a Driver of CAR T Cell–Associated Neurotoxicity

(2017) Crystal L. Mackall et al.   Cancer Discovery

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

A cellular platform for the evaluation of immune checkpoint molecules

(2017) Sabrina Jutz et al.   Oncotarget

An engineered protein antagonist of K-Ras/B-Raf interaction

(2017) Monique J. Kauke et al.   Scientific Reports

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

(2016) Michael W. Traxlmayr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1

(2016) Sabrina Jutz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening

(2016) Hansi Zhang et al.   Scientific Reports

Design of chimeric antigen receptors with integrated controllable transient functions

(2016) Alexandre Juillerat et al.   Scientific Reports

The Menagerie of Human Lipocalins: A Natural Protein Scaffold for Molecular Recognition of Physiological Compounds

(2015) André Schiefner et al.   ACCOUNTS OF CHEMICAL RESEARCH

The quest for spatio-temporal control of CAR T cells

(2015) Jie Sun et al.   CELL RESEARCH

Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells

(2015) Stephanie Voß et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Non-immunoglobulin scaffolds: a focus on their targets

(2015) Katja Škrlec et al.   TRENDS IN BIOTECHNOLOGY

A systematic analysis of human lipocalin family and its expression in esophageal carcinoma

(2015) Ze-Peng Du et al.   Scientific Reports

Structure-Based Phylogenetic Analysis of the Lipocalin Superfamily

(2015) Balasubramanian Lakshmi et al.   PLoS One

Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4

(2014) Yingcai Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticalins: Exploiting a non-Ig scaffold with hypervariable loops for the engineering of binding proteins

(2013) A. Richter et al.   FEBS LETTERS

Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology

(2013) Robert DeRose et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Protein Tango: The Toolbox to Capture Interacting Partners

(2012) Anna Rutkowska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein translocation as a tool: The current rapamycin story

(2012) Mateusz Putyrski et al.   FEBS LETTERS

Highly Stable Binding Proteins Derived from the Hyperthermophilic Sso7d Scaffold

(2011) Nimish Gera et al.   JOURNAL OF MOLECULAR BIOLOGY

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability and CDR Composition Biases Enrich Binder Functionality Landscapes

(2010) Benjamin J. Hackel et al.   JOURNAL OF MOLECULAR BIOLOGY

The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold

(2010) B. J. Hackel et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity

(2009) Daniel A. Breustedt et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

pH-Dependent Conformational Changes in Tear Lipocalin by Site-Directed Tryptophan Fluorescence

(2009) Oktay K. Gasymov et al.   BIOCHEMISTRY

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levelsin Vivo

(2009) Alykhan Motani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Alternative binding proteins: Anticalins - harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities

(2008) Arne Skerra   FEBS Journal

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

(2008) Benjamin J. Hackel et al.   JOURNAL OF MOLECULAR BIOLOGY