Article
Chemistry, Multidisciplinary
Yixin Tian, Jiapeng Yin, Chengyao Wang, Zhenliang He, Jingyi Xie, Xiaoshan Feng, Yang Zhou, Tianyu Ma, Yang Xie, Xue Li, Tianming Yang, Chi Ren, Chengyu Li, Zhengtuo Zhao
Summary: Researchers have developed a mechanically robust ultraflexible electrode array, the MERF, for high-density, large-scale, and chronic recording of neurons in the nonhuman primate brain. The MERF array has shown promising results in basic neuroscience studies and brain-machine interface applications.
Article
Neurosciences
Wentao Hu, Silei Zhu, Farran Briggs, Marvin M. Doyley
Summary: In this study, researchers used functional ultrasound imaging (fUS) to reveal the 3D structure of orientation domains in the visual cortex (V1). They found that these domains are cone-shaped rather than columnar and that their shape and spacing can vary across different regions of V1.
Article
Multidisciplinary Sciences
Taisuke Yoneda, Kenji Hayashi, Yumiko Yoshimura
Summary: This study aims to characterize the functional properties and experience-dependent plasticity of surviving subplate neurons in the late stage of cortical development. The results show that subplate neurons exhibit broad tuning in sensory responses and can undergo visual plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Ophthalmology
Sinan Liu, Bingyang Zhao, Chaoqun Shi, Xuying Ma, Bernhard A. Sabel, Xiping Chen, Luyang Tao
Summary: The study revealed that visual cortical asymmetry has a significant impact on the neurophysiological oscillations and connections of attention networks, with differences in power and connectivity patterns within the nodes of VAN and DAN between the dominant and nondominant eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Neurosciences
K. Tang-Wright, J. E. T. Smith, H. Bridge, K. L. Miller, T. B. Dyrby, B. Ahmed, N. L. Reislev, J. Sallet, A. J. Parker, K. Krug
Summary: Researchers used high-resolution postmortem dMRI and probabilistic tractography to generate retinotopic maps of the LGN and V5/MT in rhesus macaque brains, confirming differential connectivity of magnocellular and parvocellular LGN compartments with V1 at different visual field positions. The study findings suggest that tractography based on dMRI is sensitive enough to reveal the order connections between topographically organized neural structures and their functional organization.
Article
Multidisciplinary Sciences
Nadege Sarrazin, Estelle Chavret-Reculon, Corinne Bachelin, Mehdi Felfli, Rafik Arab, Sophie Gilardeau, Elena Brazhnikova, Elisabeth Dubus, Lydia Yaha-Cherif, Jean Lorenceau, Serge Picaud, Serge Rosolen, Pierre Moissonnier, Pierre Pouget, Anne Baron-Van Evercooren
Summary: This study focuses on the long-term effects of toxin-induced demyelination of the macaque optic nerve and its impact on remyelination, axon preservation, and visual functions. The findings reveal visual impairment, including damage to the optic nerve and retina. This nonhuman primate model replicates key features of multiple sclerosis lesions, making it valuable for studying new therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Joshua H. Siegle, Peter Ledochowitsch, Xiaoxuan Jia, Daniel J. Millman, Gabriel K. Ocker, Shiella Caldejon, Linzy Casal, Andy Cho, Daniel J. Denman, Severine Durand, Peter A. Groblewski, Gregg Heller, India Kato, Sara Kivikas, Jerome Lecoq, Chelsea Nayan, Kiet Ngo, Philip R. Nicovich, Kat North, Tamina K. Ramirez, Jackie Swapp, Xana Waughman, Ali Williford, Shawn R. Olsen, Christof Koch, Michael A. Buice, Saskia E. J. de Vries
Summary: This study compared evoked responses in the visual cortex of awake mice using extracellular electrophysiology and two-photon calcium imaging, finding more responsive neurons in electrophysiology and higher stimulus selectivity in calcium imaging, partially reconciled by applying a spikes-to-calcium forward model.
Review
Ophthalmology
Guiqu Wang, Longqian Liu
Summary: This article systematically searched the PubMed database to highlight the current progress and promises of functional magnetic resonance imaging (fMRI) technology in amblyopia research. The neural mechanism of amblyopia, comparison of different types of amblyopia, and evaluation of therapeutic effect were explored.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Neurosciences
Kirstie J. Salinas, Carey Y. L. Huh, Jack H. Zeitoun, Sunil P. Gandhi
Summary: This study investigates the impact of binocular visual input on the functional differentiation of visual cortical areas, finding that imbalanced binocular vision during development affects the spatiotemporal tuning of neurons in V1, LM, and PM, and reshapes the tuning properties driven by the two eyes. Results reveal that balanced binocular vision is essential for driving the functional differentiation of visual cortical areas during development.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weimin Zheng, Ling Wang, Qian Chen, Xuejing Li, Xin Chen, Wen Qin, Kuncheng Li, Jie Lu, Nan Chen
Summary: The study found that CTSCI patients exhibit altered neural function in the right lingual gyrus and right middle frontal gyrus, as well as changes in functional connectivity between these regions and Vermis_3. These changes are associated with clinical manifestations such as visual analog scale scores, indicating a potential theoretical basis for rehabilitation techniques targeting visual, emotion, and cognition in CTSCI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Behavioral Sciences
Mathilda Froesel, Celine Cappe, Suliann Ben Hamed
Summary: This study focuses on the contribution of the pulvinar to multisensory integration, suggesting that the pulvinar combines multiple sources of sensory information to enhance fast responses to the environment and acts as a general regulation hub for adaptive and flexible cognition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Megan Roussy, Benjamin Corrigan, Rogelio Luna, Roberto A. Gulli, Adam J. Sachs, Lena Palaniyappan, Julio C. Martinez-Trujilio
Summary: The study found that LPFC neurons maintain robust and distinct neural codes for mnemonic and perceptual visuospatial representations during naturalistic vision, with animals using different behavioral strategies for working memory and perception tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mona Rosenke, Rick van Hoof, Job van den Hurk, Kalanit Grill-Spector, Rainer Goebel
Summary: This study developed and validated a functional ROI atlas of early visual and category-selective regions in human ventral and lateral occipito-temporal cortex. Cortex-based alignment showed lower between-subject variability compared to nonlinear volumetric alignment. The atlas accurately predicted the location of ventral temporal cortex ROIs and demonstrated the utility of identifying category-specific regions in healthy subjects and populations where functional localizers cannot be run.
Article
Neurosciences
Rui Yuan, Jordan M. Nechvatal, Christine L. Buckmaster, Sarah Ayash, Karen J. Parker, Alan F. Schatzberg, David M. Lyons, Vinod Menon
Summary: Correlational studies indicate that exposure to early life stress can lead to long-term effects on neural circuits related to stress vulnerability and resilience, ultimately affecting mental health disorders. Specifically, in female squirrel monkeys, intermittent stress was found to cause hyper-connectivity between the prefrontal cortex and subcortical regions known to be influenced by stress, potentially impacting behavior and cognitive control in adulthood.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Rossano, Takuya Toyonaga, Eric Berg, Isabella Lorence, Krista Fowles, Nabeel Nabulsi, Jim Ropchan, Songye Li, Yunpeng Ye, Zachary Felchner, David Kukis, Yiyun Huang, Helene Benveniste, Alice F. Tarantal, Stephanie Groman, Richard E. Carson
Summary: This study assessed synaptic density changes in the developing fetal brain using positron emission tomography (PET) radioligands. The results showed an increase in SV2A concentration during the third trimester, with lower levels in cortical regions. Furthermore, the post-mortem quantification of SV2A density correlated significantly with the PET measurements.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cell Biology
Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin, Archana Padmanabhan Nair, Meysam Yazdankhah, Anastasia Strizhakova, Mark A. Ross, Haitao Liu, Stacey Hose, Nadezda A. Stepicheva, Olivia Chowdhury, Mihir Nemani, Vishnu Maddipatla, Rhonda Grebe, Manjula Das, Kira L. Lathrop, Jose-Alain Sahel, J. Samuel Zigler, Jiang Qian, Arkasubhra Ghosh, Yuri Sergeev, James T. Handa, Claudette M. St Croix, Debasish Sinha
Summary: In dry age-related macular degeneration, increased LCN2 levels lead to pathological changes in retinal pigmented epithelial cells, which are known to drive dry AMD pathology. By regulating autophagy and ferroptosis activities, LCN2 is involved in the development of AMD and provides a potential therapeutic strategy.
Editorial Material
Ophthalmology
Gabriel Hallali, Sjoukje E. Loudon, Anthony G. Robson, Saddek Mohand-Said, Xavier Zanlonghi, Jose-Alain Sahel, Antony T. Moore, Isabelle Audo
ACTA OPHTHALMOLOGICA
(2023)
Article
Clinical Neurology
Nancy J. Newman, Patrick Yu-Wai-Man, Prem S. Subramanian, Mark L. Moster, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Valerio Carelli, Valerie Biousse, Catherine Vignal-Clermont, Robert C. Sergott, Alfredo A. Sadun, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Fabienne Bazin, Michel Roux, Eric D. Cox, Magali Taiel, Jose-Alain Sahel
Summary: Leber hereditary optic neuropathy (LHON) is a mitochondrial blindness caused by the m.11778G>A mutation. The REFLECT phase 3 study investigated the efficacy and safety of lenadogene nolparvovec gene therapy in LHON patients. It showed improvement in visual acuity, with better results in patients who received bilateral treatment. The trial demonstrated a favorable benefit/risk profile for bilateral injections compared to unilateral injections.
Editorial Material
Medicine, Research & Experimental
Boris Rosin, Jose-Alain Sahel
Summary: Ocular and specifically retinal toxicities caused by systemic medications are common and cover various disease modalities. Established follow-up protocols are in place for many of these drugs to ensure timely detection and cessation of therapy. The recent study by Kong et al (2023) in EMBO Molecular Medicine investigated the retinal toxicity induced by deferoxamine (DFO) using both in vivo and in vitro techniques. Their findings suggest a potential protective role for alpha-ketoglutarate (AKG) supplementation against DFO toxicity.
EMBO MOLECULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Justine Robin, Charlie Demene, Baptiste Heiles, Victor Blanvillain, Liene Puke, Fabienne Perren, Mickael Tanter
Summary: This study proposes an adaptive aberration correction technique for imaging the human brain vasculature using intravenously injected microbubbles. The technique improves image quality and increases contrast and the number of detected microbubble tracks. It has significant implications for better diagnosis and follow-up of brain pathologies and makes transcranial ultrasound imaging possible in difficult-to-image human adults.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Amrish Selvam, Sumit Randhir Singh, Supriya Arora, Manan Patel, Arnim Kuchhal, Stavan Shah, Joshua Ong, Mohammed Abdul Rasheed, Shanmukh Reddy Manne, Mohammed Nasar Ibrahim, Jose-Alain Sahel, Kiran Kumar Vupparaboina, Jay Chhablani
Summary: We conducted an automated analysis of pigment epithelial detachments (PEDs) in neovascular age related macular degeneration (nAMD) to estimate the areas of serous, neovascular, and fibrous tissues within the PEDs. By manually segmenting the PEDs and filtering the pixels using 2D kernels, we were able to classify them as serous, neovascular, or fibrous. Using specific PED composition indices, we calculated the relative areas of each tissue type within the PEDs. The accuracy of segmentation and classification was graded, and overall repeatability and reproducibility were high.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Valerio Carelli, Nancy J. Newman, Patrick Yu-Wai-Man, Valerie Biousse, Mark L. Moster, Prem S. Subramanian, Catherine Vignal-Clermont, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Robert C. Sergott, Thomas Klopstock, Alfredo A. Sadun, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Jean Francois Girmens, Chiara La Morgia, Adam A. DeBusk, Neringa Jurkute, Claudia Priglinger, Rustum Karanjia, Constant Josse, Julie Salzmann, Francois Montestruc, Michel Roux, Magali Taiel, Jose-Alain Sahel, The Lhon Study Group
Summary: Lenadogene nolparvovec is a promising gene therapy for LHON patients with MT-ND4 mutation, showing sustained visual acuity improvement compared to natural history. Incorporation of data from the latest trial REFLECT indicates that bilateral injection may offer added benefits over unilateral injection.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Nanoscience & Nanotechnology
Sara Cadoni, Charlie Demene, Ignacio Alcala, Matthieu Provansal, Diep Nguyen, Dasha Nelidova, Guillaume Labernede, Jules Lubetzki, Ruben Goulet, Emma Burban, Julie Degardin, Manuel Simonutti, Gregory Gauvain, Fabrice Arcizet, Olivier Marre, Deniz Dalkara, Botond Roska, Jose Alain Sahel, Mickael Tanter, Serge Picaud
Summary: Researchers have successfully achieved precise control and activation of retinal and cortical neurons by expressing ultrasound-sensitive proteins and combining unconventional high-frequency ultrasound stimulation. The spatiotemporal resolution and acoustic energy deposit achieved are compatible with the requirements of visual restoration. Sonogenetics provides neuron-specific activation at high spatiotemporal resolution both in retina and in the deep visual cortex, providing a less invasive approach for visual restoration compared to current brain-machine interfaces.
NATURE NANOTECHNOLOGY
(2023)
Article
Physics, Multidisciplinary
Samuel Hidalgo-Caballero, Surabhi Kottigegollahalli Sreenivas, Vincent Bacot, Sander Wildeman, Maxime Harazi, Xiaoping Jia, Arnaud Tourin, Mathias Fink, Alvaro Cassinelli, Matthieu Labousse, Emmanuel Fort
Summary: This article presents a counterintuitive concept of achieving time reversal of waves by using a transitory dissipation pulse. By applying sudden and strong damping in a limited time, a time-reversed wave can be generated. In the case of high damping shock, the initial wave freezes by maintaining the wave amplitude and cancelling its time derivative, resulting in two counterpropagating waves with halved amplitude and opposite time evolutions. This damping-based time reversal is demonstrated using phonon waves in a lattice of interacting magnets on an air cushion, and computer simulations show its applicability to broadband time reversal in complex disordered systems.
PHYSICAL REVIEW LETTERS
(2023)
Article
Cell Biology
Julien Claron, Matthieu Provansal, Quentin Salardaine, Pierre Tissier, Alexandre Dizeux, Thomas Deffieux, Serge Picaud, Mickael Tanter, Fabrice Arcizet, Pierre Pouget
Summary: To better understand the brain's role in primate behavior, simultaneous recording of neural activity at different spatiotemporal scales is necessary but challenging. This study uses functional ultrasound imaging and single-unit activity (SUA) recordings in macaque monkeys to show that SUA can estimate neurovascular response below the typical fMRI spatial resolution. The study also finds that SUA and cerebral blood volume (CBV) activities are not correlated during resting state but are correlated during tasks, suggesting implications for interpreting functional imaging findings.
Article
Medicine, General & Internal
Guillaume Goudot, Anatole Jimenez, Nassim Mohamedi, Jonas Sitruk, Lina Khider, Helene Mortelette, Clement Papadacci, Fabien Hyafil, Mickael Tanter, Emmanuel Messas, Mathieu Pernot, Tristan Mirault
Summary: Ultrasound localization microscopy (ULM) based on ultrafast ultrasound imaging of circulating microbubbles can visualize microvascular blood flows in vivo up to the micron scale. This study aimed to perform vasa vasorum ULM of the carotid wall in patients with Takayasu arteritis (TA) and demonstrate that ULM can provide imaging markers to assess TA activity.
Article
Biology
Hugo J. Ladret, Nelson Cortes, Lamyae Ikan, Frederic Chavane, Christian Casanova, Laurent U. Perrinet
Summary: This study identifies two typical response types of neurons in the cat primary visual cortex to sensory variance. One type of response is resilient to changes in variance and co-encodes the sensory feature and its variance, improving the quality of orientation encoding. The existence of these variance-specific responses can be explained by a model of intracortical recurrent connectivity.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Lucie Churet, Melanie Marie, Hanen Khabou, Deniz Dalkara, Jose-Alain Sahel, Thierry Leveillard, Florence Lorget
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Melanie Marie, Lucie Churet, Gregg Prawdzik, Pierre-Axel Vinot, Thierry Leveillard, Jose-Alain Sahel, Myriam Marussig, Florence Lorget
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Baptiste Wilmet, Jacques Callebert, Robert Duvoisin, Ruben Goulet, Christophe Tourain, Christelle Michiels, Helen Frederiksen, Frank Schaeffel, Olivier Marre, Jose Alain Sahel, Isabelle Audo, Serge Picaud, Christina Zeitz
Summary: Mutations in the GPR179 gene are a common cause of autosomal recessive complete congenital stationary night blindness (cCSNB). This study found that the absence of Gpr179 and the impaired ON-pathway may lead to myopic features in a mouse model of cCSNB. The altered dopaminergic system in Gpr179(-/-) mice is associated with an increased susceptibility to lens-induced myopia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)