标题
Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice
作者
关键词
Mouse models, Renal cancer, Kidneys, Aging and cancer, Haploinsufficiency, Cancer epidemiology, Inflammation, Head and neck cancers
出版物
PLoS One
Volume 15, Issue 6, Pages e0234910
出版商
Public Library of Science (PLoS)
发表日期
2020-06-20
DOI
10.1371/journal.pone.0234910
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
- (2018) Yuhan Zhao et al. eLife
- The role of klotho in chronic kidney disease
- (2018) Di Zou et al. BMC Nephrology
- RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
- (2017) Ravi Jahagirdar et al. MOLECULAR PHARMACOLOGY
- The role of sirtuins in aging and age-related diseases
- (2016) Mateusz Wątroba et al. Advances in Medical Sciences
- BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma
- (2016) Sudan N. Loganathan et al. Oncotarget
- Genome Stability Requires p53
- (2016) Christine M. Eischen Cold Spring Harbor Perspectives in Medicine
- Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study
- (2016) Céline Berthon et al. Lancet Haematology
- Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study
- (2016) Sandy Amorim et al. Lancet Haematology
- Toward a BETter grasp of acetyl-lysine readers
- (2015) Catherine Porcher BLOOD
- BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses
- (2015) Tarja Kokkola et al. CHEMBIOCHEM
- Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
- (2015) Yasumichi Arai et al. EBioMedicine
- Genetics and epigenetics of aging and longevity
- (2014) Alexey Moskalev et al. CELL CYCLE
- Sex-specific behavioral traits in theBrd2mouse model of juvenile myoclonic epilepsy
- (2014) T. Chachua et al. GENES BRAIN AND BEHAVIOR
- Bromodomain and Extraterminal Proteins Suppress NF-E2-Related Factor 2-Mediated Antioxidant Gene Expression
- (2014) C. Michaeloudes et al. JOURNAL OF IMMUNOLOGY
- SIRT1 in Neurodevelopment and Brain Senescence
- (2014) A. Zara Herskovits et al. NEURON
- Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
- (2014) Diana Jurk et al. Nature Communications
- SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
- (2013) Evi M. Mercken et al. AGING CELL
- Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
- (2013) Akiko Satoh et al. Cell Metabolism
- Mice as a Mammalian Model for Research on the Genetics of Aging
- (2013) R. Yuan et al. ILAR JOURNAL
- BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses
- (2013) A. C. Belkina et al. JOURNAL OF IMMUNOLOGY
- The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
- (2013) Anna C. Belkina et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing
- (2013) Jarmila Hnilicová et al. MOLECULAR BIOLOGY OF THE CELL
- Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- (2013) Kazuhiro Hasegawa et al. NATURE MEDICINE
- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
- (2013) Alexandre Puissant et al. Cancer Discovery
- Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
- (2013) Liou Y Sun et al. eLife
- DNA methylation age of human tissues and cell types
- (2013) Steve Horvath GENOME BIOLOGY
- Will the real aging Sirtuin please stand up?
- (2012) Chen-Yu Liao et al. CELL RESEARCH
- A persistent level of Cisd2 extends healthy lifespan and delays aging in mice
- (2012) Chia-Yu Wu et al. HUMAN MOLECULAR GENETICS
- Mammalian Sirtuins and Energy Metabolism
- (2012) Xiaoling Li et al. International Journal of Biological Sciences
- SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
- (2012) Hongying Yang et al. PLoS One
- Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- (2011) Hyunkyung Jeong et al. NATURE MEDICINE
- GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy
- (2011) Libor Velíšek et al. PLoS One
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- (2010) Gizem Donmez et al. CELL
- SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
- (2010) S. Michan et al. JOURNAL OF NEUROSCIENCE
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- (2010) Jun Gao et al. NATURE
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
- (2010) Sang-Won Min et al. NEURON
- Aging increases Oxidative Stress and Renal Expression of Oxidant and Antioxidant Enzymes that Are Associated with an Increased Trend in Systolic Blood Pressure
- (2010) Pedro Gomes et al. Oxidative Medicine and Cellular Longevity
- Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
- (2009) Rong Yuan et al. AGING CELL
- SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
- (2009) Takeshi Yoshizaki et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Brd2disruption in mice causes severe obesity without Type 2 diabetes
- (2009) Fangnian Wang et al. BIOCHEMICAL JOURNAL
- The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis
- (2009) Aron Gyuris et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse
- (2009) Enyuan Shang et al. DEVELOPMENTAL DYNAMICS
- Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice
- (2009) Y.-F. Chen et al. GENES & DEVELOPMENT
- Tumor Suppressive Functions of p53
- (2009) J. T. Zilfou et al. Cold Spring Harbor Perspectives in Biology
- SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
- (2008) Ying Li et al. Cell Metabolism
- SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
- (2008) Gino Boily et al. PLoS One
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