BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

Sirt1 activation by resveratrol is substrate sequence-selective

(2016) Mahadevan Lakshminarasimhan et al.   Aging-US

AROS has a context-dependent effect on SIRT1

(2014) Tarja Kokkola et al.   FEBS LETTERS

Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell

(2014) Li Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151

(2014) Stuart J. Gallagher et al.   Pigment Cell & Melanoma Research

Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells

(2014) Younis M. Khan et al.   PLoS One

Chloropicrin-induced toxic responses in human lung epithelial cells

(2014) Maija Pesonen et al.   TOXICOLOGY LETTERS

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response

(2014) M Hussong et al.   Cell Death & Disease

SIRT1 Regulates the Human Alveolar Epithelial A549 Cell Apoptosis Induced byPseudomonas AeruginosaLipopolysaccharide

(2013) Xiaoli Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

(2013) Paolo Mellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

(2013) J. R. P. Knight et al.   Open Biology

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells

(2012) Agnes W. Boots et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors

(2009) Päivi H. Kiviranta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors

(2008) Tero Huhtiniemi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

(2008) B. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization

(2008) S. Verstraelen et al.   TOXICOLOGY IN VITRO