Article
Nutrition & Dietetics
Nicole Fearnbach, Amanda E. Staiano, Neil M. Johannsen, Daniel S. Hsia, Robbie A. Beyl, Owen T. Carmichael, Corby K. Martin
Summary: Exercise may impact energy intake in adolescents by influencing appetite states rather than traits. Additionally, baseline energy intake after exercise is associated with weight change over time, indicating that appetitive cues play a significant role in post-exercise energy intake.
Article
Nutrition & Dietetics
Rodrigo Chamorro, Karen Basfi-fer, Bernardita Sepulveda, Rut Farias, Pamela Rojas, Fernando Carrasco, Juana Codoceo, Jorge Inostroza, Manuel Ruz
Summary: This study assessed the association between meal timing and diet composition and metabolic parameters in patients with type-2 diabetes. The results showed that increased energy intake late during the day was related to increased total food and daily energy intake. Conversely, a greater proportion of total carbohydrates eaten early in the day was related to lower total energy intake. These findings suggest that earlier food intake may play an important role in dietary and metabolic control in patients with type-2 diabetes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Gabriela P. Teixeira, Kisian C. Guimaraes, Ana Gabriela N. S. Soares, Elaine C. Marqueze, Claudia R. C. Moreno, Maria C. Mota, Cibele A. Crispim
Summary: Recent studies indicate that chronotype is associated with dietary habits and obesity. Evening types are more likely to have unhealthy eating habits such as eating late at night, skipping breakfast, and consuming processed/ultraprocessed foods. Morning types are more likely to have healthy eating habits such as eating breakfast early and consuming fresh/minimally processed foods. Intermediate types have eating patterns and health behaviors more similar to early types than late types.
Article
Physiology
Igor B. Mekjavic, Mojca Amon, Elizabeth J. Simpson, Roger Koelegard, Ola Eiken, Ian A. Macdonald
Summary: This study aimed to investigate the effect of hypoxia on metabolism in men with excess weight. The results showed that hypoxia increased energy expenditure and levels of PYY, potentially leading to appetite inhibition and weight loss, but it also indicated the development of insulin resistance.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Rodrigo Chamorro, Celine Jouffe, Henrik Oster, N. Henriette Uhlenhaut, Sebastian M. Meyhoefer
Summary: This review article discusses the circadian clock's role in regulating physiological and behavioral functions, especially in relation to food intake and metabolic regulation. It emphasizes the importance of meal timing in controlling appetite and metabolic responses. The article provides a fundamental research axis for maintaining a healthy eating behavior by exploring the mechanisms of food intake regulation and focusing on the crucial role of the circadian clock.
Article
Endocrinology & Metabolism
Sarah N. Framnes-DeBoer, Aaron A. Jones, Michelle Y. Kang, Kat Propsom, Lauren R. Nelson, Deanna M. Arble
Summary: Pairing repeated hypoxic episodes to a mouse's resting phase during the day preferentially decreases carbohydrate intake and results in a switch to metabolic fat oxidation. The timing of intermittent hypoxia should be considered when calculating sleep apnea's effects on metabolic outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Isabel E. Young, Amudha Poobalan, Katharine Steinbeck, Helen T. O'Connor, Helen M. Parker
Summary: Consuming a greater proportion of total energy intake earlier in the day may lead to greater weight loss and improvements in health markers. This systematic review found that distributing energy intake with a focus on earlier intake resulted in significantly greater weight loss and improvements in metabolic health markers. These findings highlight the potential benefits of prioritizing earlier meal times for weight management and overall health.
Review
Nutrition & Dietetics
Sevag Hamamah, Arman Amin, Abdul Latif Al-Kassir, Judith Chuang, Mihai Covasa
Summary: Obesity is a complex disease that is becoming more prevalent worldwide. Recent research suggests that changes in gut microbiota, influenced by the consumption of dietary fats, play a key role in the development of obesity. These alterations in gut microbiota can affect important satiation signals, leading to hyperphagia and obesity. This review discusses the mechanisms by which gut microbiota influences satiation signals, the effects of dietary interventions on gut microbiota and satiety signals, and microbiota optimizing therapies to combat obesity.
Article
Nutrition & Dietetics
Paul R. Hibbing, Robin P. Shook, Satchidananda Panda, Emily N. C. Manoogian, Douglas G. Mashek, Lisa S. Chow
Summary: This study introduced an accelerometer-based intake-balance method to assess energy intake in a time-restricted eating trial. The estimates derived from the accelerometer showed good agreement with estimates from the National Institute of Diabetes and Digestive and Kidney Diseases' body weight planner. This method may be a feasible alternative to self-report measures of energy intake.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Surgery
Marine Cossec, Florian Atger, Claire Blanchard, David Jacobi
Summary: The timing of food intake can affect circadian rhythms and metabolism, potentially impacting obesity. Studies suggest a correlation between meal timing and weight loss after bariatric surgery in adults, with evidence pointing towards late-night food consumption hindering weight loss progress.
Article
Endocrinology & Metabolism
Rizaldy C. Zapata, Dinghong Zhang, Dongmin Yoon, Chanond A. Nasamran, Daisy R. Chilin-Fuentes, Avraham Libster, Besma S. Chaudry, Mariela Lopez-Valencia, Devasena Ponnalagu, Harpreet Singh, Michael Petrascheck, Olivia Osborn
Summary: Clic1 inhibition reduces food intake and body weight in mouse models, suggesting it as a potential therapeutic target for obesity treatment.
MOLECULAR METABOLISM
(2023)
Article
Nutrition & Dietetics
Luigi Schiavo, Silvana Mirella Aliberti, Pietro Calabrese, Anna Maria Senatore, Lucia Severino, Gerardo Sarno, Antonio Iannelli, Vincenzo Pilone
Summary: Taste perception changes after sleeve gastrectomy (SG), leading to a reduced preference for high-sugar and high-fat foods and an increased preference for low-sugar and low-fat foods. The intake frequency of different food classes also changes after SG.
Article
Nutrition & Dietetics
Maria Carlota Dao, Sophie Thiron, Ellen Messer, Camille Sergeant, Anne Sevigne, Camille Huart, Melinda Rossi, Ilyssa Silverman, Kylie Sakaida, Pierre Bel Lassen, Charlotte Sarrat, Laura Arciniegas, Sai Krupa Das, Nicolas Gausseres, Karine Clement, Susan B. Roberts
Summary: This comparative qualitative study between France and the United States identified both common and divergent attitudes towards food culture and eating behaviors, highlighting the influence of factors such as social interactions, environmental concerns, and perceptions of natural versus processed foods. Further research is needed to develop effective interventions to address obesity in different populations.
Review
Pediatrics
Victoria E. Goldman, Juan C. Espinoza, Alaina P. Vidmar
Summary: Pediatric obesity rates continue to rise with adverse effects on health outcomes. Obesity can impact the efficacy and use of treatment and imaging modalities in the evaluation and management of acute pediatric conditions. There is a lack of clinical guidelines on managing severe obesity in the inpatient setting. This study presents a literature review and three patient cases with a weight-management protocol for non-surgical management of severe obesity in children admitted for other acute medical reasons.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Lucrezia Bertoni, Romina Valentini, Alessandra Zattarin, Anna Belligoli, Silvia Bettini, Roberto Vettor, Mirto Foletto, Paolo Spinella, Luca Busetto
Summary: This study evaluated protein intake in patients in the first three months after laparoscopic sleeve gastrectomy (SG). The findings showed that protein intake from foods was insufficient, and the use of protein supplementation increased total protein intake, but still remained below recommended levels.
Article
Endocrinology & Metabolism
Andrew W. McHill, Lindsey S. Brown, Andrew J. K. Phillips, Laura K. Barger, Marta Garaulet, Frank A. J. L. Scheer, Elizabeth B. Klerman
Summary: This study examined the relationship between the timing of energy intake and body composition based on mathematically modeled circadian timing and in-laboratory collected metrics. The findings suggest that the use of mathematically modeled circadian timing can provide similar results to in-laboratory measurements, which may be beneficial in time-based interventions.
Article
Biochemical Research Methods
Wei Wang, Robin K. Yuan, Jude F. Mitchell, Kirsi-Marja Zitting, Melissa A. St Hilaire, James K. Wyatt, Frank A. J. L. Scheer, Kenneth P. Wright, Emery N. Brown, Joseph M. Ronda, Elizabeth B. Klerman, Jeanne F. Duffy, Derk-Jan Dijk, Charles A. Czeisler
Summary: Circadian clocks drive cyclic variations in many aspects of physiology, but it is often important to quantify the relative contributions of these factors. Nathaniel Kleitman's forced desynchrony (FD) protocol was designed to assess endogenous circadian rhythmicity and to separate circadian from evoked components of daily rhythms.
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Lei Gao, Peng Li, Nicole Gaykova, Xi Zheng, Chenlu Gao, Jacqueline M. Lane, Richa Saxena, Frank A. J. L. Scheer, Martin K. Rutter, Oluwaseun Akeju, Kun Hu
Summary: This study found a bidirectional link between delirium and dementia, suggesting that they may be mutually related. Furthermore, disturbances in the sleep-wake rhythm were associated with an increased risk of delirium and progression to dementia. These findings highlight the importance of sleep-wake rhythm in cognitive function.
ANNALS OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Qian, Qian P. Xiao, Michael Walkup, Mace L. Coday, Melissa Erickson, Jessica M. Unick, John Jakicic, Kun Hu, Frank A. J. L. Scheer, Roeland J. W. Middelbeek, Look AHEAD Res Grp
Summary: This study aimed to determine the association of the time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control in adults with overweight/obesity and type 2 diabetes. The study found that bMVPA performed in the afternoon is associated with improvements in glycemic control, especially within the initial 12 months of an intervention.
Article
Endocrinology & Metabolism
Oscar Osorio-Conles, Amanda Jimenez, Ainitze Ibarzabal, Jose Maria Balibrea, Ana de Hollanda, Josep Vidal
Summary: This study found that the impact of type 2 diabetes mellitus on limited weight loss after bariatric surgery is controversial. The study revealed that type 2 diabetes is associated with a 5% lesser mid-term weight loss. Additionally, dysregulated expression of the ATG7 gene in subcutaneous adipose tissue may contribute to limited weight loss after surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Aviva Y. Cohn, Leilah K. Grant, Margo D. Nathan, Aleta Wiley, Mathena Abramson, Jessica A. Harder, Sybil Crawford, Elizabeth B. Klerman, Frank A. J. L. Scheer, Ursula B. Kaiser, Shadab A. Rahman, Hadine Joffe
Summary: This study investigated the effects of menopause-related sleep disturbance and estradiol decline on cortisol levels in healthy young women. The results showed that sleep fragmentation increased bedtime cortisol levels and decreased cortisol awakening response. Furthermore, suppression of estradiol also decreased bedtime cortisol levels. These findings suggest that menopause-related sleep disturbance and estradiol decline can negatively affect the activity of the hypothalamic-pituitary-adrenal axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Marta Garaulet, Barbara Vizmanos, Teresa Muela, Alejandra Betancourt-Nunez, Maria-angeles Bonmati-Carrion, Celine Vetter, Hassan S. Dashti, Richa Saxena, Frank A. J. L. Scheer
Summary: This study aimed to investigate the relationship between being an evening type and reporting emotional eating behaviors. The results showed that evening types had higher scores on emotional eating and were more likely to be emotional eaters. They also scored higher on disinhibition/overeating and food craving factors. A meta-analysis revealed that being an evening type was associated with a higher score on emotional eating. Furthermore, individuals with late dim-light melatonin onset showed higher scores on emotional eating.
Article
Endocrinology & Metabolism
Barbara Vizmanos, Ana Isabel Cascales, Maria Rodriguez-Martin, Diego Salmeron, Eva Morales, Aurora Aragon-Alonso, Frank A. J. L. Scheer, Marta Garaulet
Summary: This study aimed to investigate the association between siestas and obesity, considering siesta duration and whether siesta traits and/or lifestyle factors mediate this association. The results showed that long siestas were associated with higher BMI, waist circumference, fasting glucose, blood pressure, and increased prevalence of MetS. However, short siestas were associated with a lower probability of elevated blood pressure. Various factors, including smoking, sleep and eating schedules, energy intake, and siesta location, mediated the association of siestas with obesity and MetS.
Article
Clinical Neurology
Rudy W. Chen, Ma Cherrysse Ulsa, Peng Li, Chenlu Gao, Xi Zheng, Jiawei Xu, Yong Luo, Shiqian Shen, Jacqueline Lane, Frank A. J. L. Scheer, Kun Hu, Lei Gao
Summary: This study investigates the association between sleep behavior and opioid-related adverse events (OAEs), finding that short or long sleep duration, frequent daytime sleepiness, insomnia symptoms, and napping are associated with an increased risk of OAEs.
Article
Nutrition & Dietetics
Catalina Ramirez-Contreras, Andreu Farran-Codina, Maria Fernanda Zeron-Rugerio, Maria Izquierdo-Pulido
Summary: Image-based dietary records have been validated as tools to evaluate dietary intake, but previous studies have mainly relied on unvalidated smartphone applications for determining meal timing. This study aimed to assess the relative validity and reliability of the Remind app as an image-based method for assessing dietary intake and meal timing.
Article
Endocrinology & Metabolism
Carolina Zambrano, Agne Kulyte, Juan Lujan, Belen Rivero-Gutierrez, Fermin Sanchez de Medina, Olga Martinez-Augustin, Mikael Ryden, Frank A. J. L. Scheer, Marta Garaulet
Summary: Habitual napping may disrupt circadian expression patterns of lipase E gene, resulting in impaired lipid mobilization and increased abdominal obesity in nappers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Qian, Christopher J. J. Morris, Rosanna Caputo, Frank A. J. L. Scheer
Summary: This study examined the impact of circadian misalignment in chronic shift workers and found that it increased ghrelin levels and hunger. However, it did not significantly affect energy expenditure or respiratory exchange ratio.
Article
Medicine, General & Internal
Adriana Pane, Maria Claro, Alicia Molina-Andujar, Romina Olbeyra, Barbara Romano-Andrioni, Laura Boswell, Enrique Montagud-Marrahi, Amanda Jimenez, Ainitze Ibarzabal, Judith Viaplana, Pedro Ventura-Aguiar, Antonio J. Amor, Josep Vidal, Lilliam Flores, Ana de Hollanda
Summary: Obesity increases the risk of developing chronic kidney disease (CKD), and bariatric surgery (BS) has shown to improve obesity-related comorbidities and renal function in CKD patients. This study aimed to investigate the safety and outcomes of BS in CKD patients and found that BS was safe and effective in terms of weight loss, resolution of obesity comorbidities, and improvement of renal function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Celia Martinez-Sanchez, Octavi Bassegoda, Hongping Deng, Xenia Almodovar, Ainitze Ibarzabal, Ana de Hollanda, Raquel-Adela Martinez Garcia de la Torre, Delia Blaya, Silvia Arino, Natalia Jimenez-Esquivel, Beatriz Aguilar-Bravo, Julia Vallverdu, Carla Montironi, Oscar Osorio-Conles, Yiliam Fundora, Francisco Javier Sanchez Moreno, Alicia G. Gomez-Valades, Laia Aguilar-Corominas, Anna Soria, Elisa Pose, Adria Juanola, Marta Cervera, Martina Perez, Virginia Hernandez-Gea, Silvia Affo, Kelly S. Swanson, Joana Ferrer-Fabrega, Jose Maria Balibrea, Pau Sancho-Bru, Josep Vidal, Pere Gines, Andrew M. Smith, Isabel Graupera, Mar Coll
Summary: This study reveals the correlation between the accumulation of pro-inflammatory adipose tissue macrophages (ATMs) and liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Modulation of ATMs improves liver inflammation and fibrosis in an experimental non-alcoholic steatohepatitis (NASH) model. These findings highlight the potential of ATMs as a therapeutic target for NAFLD.
