Review
Environmental Sciences
Rahel L. Birru, Hai-Wei Liang, Fouzia Farooq, Megha Bedi, Maisa Feghali, Catherine L. Haggerty, Dara D. Mendez, Janet M. Catov, Carla A. Ng, Jennifer J. Adibi
Summary: This review highlights a novel pathway between PFAS exposure and GDM development, emphasizing that dysregulation of thyroid function and glucose metabolism may increase the risk of GDM. Studies found a positive association between PFAS and TSH, a negative association with T3 and T4, as well as a positive association with glucose and insulin levels in pregnancy.
ENVIRONMENTAL HEALTH
(2021)
Article
Endocrinology & Metabolism
Elisa Paavilainen, Kristiina Tertti, Hilkka Nikkinen, Riitta Veijola, Marja Vaarasmaki, Britt-Marie Loo, Paivi Tossavainen, Tapani Ronnemaa, Harri Niinikoski
Summary: The offspring of mothers treated with metformin for gestational diabetes mellitus showed similar growth and glucose metabolism at age 9 compared to those treated with insulin, but had a more favorable lipid profile, including higher HDL cholesterol, lower LDL cholesterol, and lower apolipoprotein B concentrations.
DIABETES OBESITY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Yao Su, Hong-Kun Wang, Xu-Pei Gan, Li Chen, Yan-Nan Cao, De-Cui Cheng, Dong-Yao Zhang, Wen-Yu Liu, Fei-Fei Li, Xian-Ming Xu
Summary: The study revealed that there is dysbiosis of the gut microbiome in patients with gestational diabetes mellitus (GDM) during the second trimester of pregnancy, and gut microbiota might be a potential diagnostic biomarker for the diagnosis, prevention, and treatment of GDM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Dongyao Zhang, Jing Sheng, Li Chen, Decui Cheng, Yannan Cao, Yao Su, Ying Jiang, Wenyu Liu, Yuexin Yu, Haoyi Jia, Pengyuan He, Li Wang, Xianming Xu
Summary: This study investigated the effects of dietary fiber supplementation on the risk of gestational diabetes mellitus in Chinese women aged 35 years and above. The results showed that dietary fiber supplementation did not reduce the incidence of gestational diabetes, but improved glucose metabolism, gestational weight gain, and preterm birth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yu Liu, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise M. Scholtens, William L. Lowe
Summary: This study analyzed metabolites in women at approximately 28 weeks' gestation and found associations with GDM and postpartum disorders of glucose metabolism. Some metabolites were identified as mediating the relationship between GDM and postpartum disorders, highlighting the pathophysiological transition from GDM to a postpartum disorder of glucose metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Sanna Mustaniemi, Elina Keikkala, Eero Kajantie, Markku Nurhonen, Antti Jylha, Laure Morin-Papunen, Hanna Ohman, Tuija Mannisto, Hannele Laivuori, Johan Eriksson, Reijo Laaksonen, Marja Vaarasmaki
Summary: This study suggests that the concentrations of four ceramides in early pregnancy are associated with the development of gestational diabetes. The highest quartiles of ceramide concentrations, along with high levels of triglycerides and LDL, are independent predictors of GDM.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid, Kare Birkeland
Summary: This study revealed significant ethnic differences in actionable ADA-HbA(1c) levels between South Asian and Nordic women with previous GDM, with important risk factors including South Asian ethnicity, GDM history, use of glucose-lowering drugs during pregnancy, older age, and higher fasting glucose levels during pregnancy.
Article
Multidisciplinary Sciences
Niina Sissala, Sanna Mustaniemi, Eero Kajantie, Marja Vaarasmaki, Peppi Koivunen
Summary: Higher maternal hemoglobin levels are an independent risk factor for gestational diabetes, but have little effect on perinatal outcome.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Zhonghan Sun, Xiong-Fei Pan, Xiao Li, Limiao Jiang, Ping Hu, Yi Wang, Yi Ye, Ping Wu, Bin Zhao, Jianguo Xu, Mengmeng Kong, Yanni Pu, Manying Zhao, Jianying Hu, Jinfeng Wang, Guo-Chong Chen, Changzheng Yuan, Yongfu Yu, Xiang Gao, Fangqing Zhao, An Pan, Yan Zheng
Summary: In this study, it was found that the diversity of gut microbial species decreased and the microbial community composition changed with advancing gestation in the control group, but no such trends were observed in gestational diabetes mellitus (GDM) patients. Certain GDM-related species and microbial metabolic pathways related to fiber fermentation were identified and found to be associated with glycemic traits. These findings suggest that the gut microbiome remodeling in GDM patients differs from controls and that dietary fiber fermentation plays a role in the influence of gut microbiome on gestational glycemic regulation.
Article
Environmental Sciences
Hanzhi Wang, Rongrong Chen, Yu Gao, Jianli Qu, Yingying Zhang, Hangbiao Jin, Meirong Zhao, Xiaoxia Bai
Summary: This study collected serum samples from pregnant women in Hangzhou between 2011 and 2012 and found that the concentrations of MBP and MiBP in the serum were positively associated with the incidence of GDM and blood glucose levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Ying Zheng, Weiwei Hou, Jing Xiao, Hongling Huang, Wenqiang Quan, Yu Chen
Summary: This study aimed to investigate whether first-trimester fasting plasma glucose (FPG), blood coagulation function, and lipid metabolism could predict the risk of gestational diabetes mellitus (GDM). Through observation and analysis of 584 pregnant women, it was found that some indicators such as FPG, APTT, TG, and pre-pregnancy BMI can serve as independent predictors of GDM. The established GDM risk prediction model has important clinical value in the early identification, intervention, and treatment of GDM.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Microbiology
Qing-Xiang Zheng, Hai-Wei Wang, Xiu-Min Jiang, Li Ge, Yu-Ting Lai, Xin-Yong Jiang, Ping-Ping Huang, Fan Chen, Xiao-Qian Chen
Summary: This study investigated the roles of gut microbiota and metabolomics in women with gestational diabetes mellitus (GDM). The study found that probiotic supplements can alleviate the pathology of GDM and reduce the levels of gut metabolites. Changes in metabolites were associated with amino acid and bile acid metabolism pathways.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kimberly A. Bertrand, Katie M. O'Brien, Lauren B. Wright, Julie R. Palmer, William J. Blot, A. Heather Eliassen, Lynn Rosenberg, Sven Sandin, Deirdre Tobias, Elisabete Weiderpass, Wei Zheng, Anthony J. Swerdlow, Minouk J. Schoemaker, Hazel B. Nichols, Dale P. Sandler
Summary: The history of gestational diabetes mellitus (GDM) is not a risk factor for breast cancer in young women. The well-established protective effect of parity on the risk of ER-positive breast cancer persists even for pregnancies complicated by GDM.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yun-Yi Liang, Ling-Yu Liu, Yan Jia, Yi Li, Jie-Na Cai, Yi Shu, Jing-Yi Tan, Pei-Yi Chen, Hong-Wei Li, Hui-Hua Cai, Xiang-Sheng Cai
Summary: This study explored the correlation between gut microbiota and blood biochemical traits, especially GLP-1, in GDM patients. The results showed that there are differences in the gut microbiota between GDM and NGT groups, and certain genera are significantly correlated with blood glucose-related indices. These findings contribute to a better understanding of the pathogenesis of GDM and may provide new insights for its treatment.
WORLD JOURNAL OF DIABETES
(2022)
Article
Environmental Sciences
Zixing Zhou, Gengdong Chen, Pengsheng Li, Jiaming Rao, Lijuan Wang, Dandan Yu, Dongxin Lin, Dazhi Fan, Shaoxin Ye, Shuzhen Wu, Xiaoyan Gou, Haiyan Wang, Xiaoling Guo, Lei Lin, Dongmei Suo, Zhengping Liu
Summary: The study found that higher concentrations of manganese and zinc, but lower concentrations of lead, calcium, and magnesium before 24 weeks of gestation were associated with increased risk of GDM and higher fasting plasma glucose levels among pregnant women. Monitoring metal concentrations within a certain range may help in early prediction of pregnancy glucose abnormalities.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Ming-liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
Article
Microbiology
Chao Kang, Bin Wang, Kanakaraju Kaliannan, Xiaolan Wang, Hedong Lang, Suocheng Hui, Li Huang, Yong Zhang, Ming Zhou, Mengting Chen, Mantian Mi
Article
Biochemistry & Molecular Biology
Xianglong Zeng, Jining Yang, Ou Hu, Juan Huang, Li Ran, Mengting Chen, Yu Zhang, Xi Zhou, Jundong Zhu, Qianyong Zhang, Long Yi, Mantian Mi
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Cell Biology
Ming-liang Chen, Long Yi, Xin Jin, Xin-yu Liang, Yong Zhou, Ting Zhang, Qi Xie, Xi Zhou, Hui Chang, Yu-jie Fu, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi
Article
Cell Biology
Yujie Huang, Xiaohui Zhu, Ka Chen, Hedong Lang, Yong Zhang, Pengfei Hou, Li Ran, Min Zhou, Jiawei Zheng, Long Yi, Mantian Mi, Qianyong Zhang
Article
Nutrition & Dietetics
Mengting Chen, Pengfei Hou, Min Zhou, Qingbo Ren, Xiaolan Wang, Li Huang, Suocheng Hui, Long Yi, Mantian Mi
CLINICAL NUTRITION
(2020)
Article
Physiology
Mingge Ding, Chaoyang Liu, Rui Shi, Mingzhe Yu, Ke Zeng, Junjun Kang, Feng Fu, Mantian Mi
Article
Sport Sciences
Pengfei Hou, Xi Zhou, Li Yu, Yu Yao, Yong Zhang, Yujie Huang, Mengtin Chen, Long Yi, Mantian Mi
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Biochemistry & Molecular Biology
Suocheng Hui, Li Huang, Xiaolan Wang, Xiaohui Zhu, Min Zhou, Mengting Chen, Long Yi, Mantian Mi
Article
Food Science & Technology
Yang Liu, Hedong Lang, Min Zhou, Li Huang, Suocheng Hui, Xiaolan Wang, Ka Chen, Mantian Mi
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Microbiology
Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi
Summary: This study found that hypoxia exposure could enhance endurance capacity. Hypoxia led to gut microbiota remodeling, increasing the abundance of beneficial genera and the production of short-chain fatty acids (SCFAs). Moreover, hypoxia significantly improved endurance by promoting mitochondrial biogenesis and improving biochemical parameters related to exercise fatigue. Antibiotics experiments and microbiota transplantation experiments demonstrated that the beneficial effects of hypoxia on exercise performance were partly dependent on the gut microbiota. Acetate and butyrate were identified as stimulators of mitochondrial biogenesis and endurance performance.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Jie Zhou, Pengfei Hou, Yu Yao, Jing Yue, Qianyong Zhang, Long Yi, Mantian Mi
Summary: DHM can protect mice fed with high-fat diet from hyperglycemia by promoting the proliferation of ILC3 cells and the production of IL-22. Additionally, DHM reduces the damage to the intestinal barrier and decreases the level of LPS by increasing IL-22 secretion. The study also reveals that SIRT3 deficiency exacerbates obesity, intestinal barrier damage, and affects the regulation of IL-22 expression by DHM.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xi Zhou, Long Yi, Hedong Lang, Jun Zhang, Qianyong Zhang, Li Yu, Jundong Zhu, Mantian Mi
Summary: The study demonstrates that DHM liposomes can alleviate liver inflammation induced by exhaustive exercise through sustained releasing and hepatic targeting. Liposome encapsulation enhances the bioavailability of DHM and provides more effective relief of liver inflammation. Furthermore, DHM liposomes can target hepatic macrophages and polarize them into an anti-inflammatory phenotype. The SIRT3/HIF-1α signaling pathway may be the major mechanism of DHM-induced macrophage polarization.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luting Wu, Min Zhou, Tianyou Li, Niu Dong, Long Yi, Qianyong Zhang, Mantian Mi
Summary: Exercise-induced physical endurance enhancement and skeletal muscle remodeling can prevent and delay the development of multiple diseases, especially metabolic syndrome. The study found that GLP-1 secretion increased during exercise and overexpression of GLP-1 in skeletal muscle enhanced endurance capacity. The mechanism involves GLP-1 receptor signaling-mediated phosphorylation of AMPK.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)