Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Michele J. Alkalay
Summary: Lactose malabsorption, celiac disease, non-celiac gluten sensitivity, and irritable bowel syndrome are conditions associated with food triggers and can cause nutritional detriments. This review provides an overview of the complex nutritional elements of these disorders, which is critical for medical providers to recognize.
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Article
Microbiology
Emma Olivia Schultz Harringer, Juliana Durack, Yvette Piceno, Vibeke Andersen, Susan V. V. Lynch
Summary: Several studies have shown that a gluten-free diet can improve disease symptoms in ulcerative colitis (UC) patients. This study hypothesized that UC-associated enteric microbes metabolize dietary gluten differently, producing immunogenic products that promote inflammation. The study found that UC patients did not consume gluten differently from healthy controls, but the profile of gluten-degrading bacteria in their stool was distinct. The products of gluten degradation by certain bacteria induced inflammation and affected barrier function in colonocyte cultures. These preliminary findings suggest a need for further investigation into the mechanisms by which gut microbiota contribute to UC pathogenesis through gluten degradation.
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Article
Nutrition & Dietetics
Leda Roncoroni, Rachele Gori, Luca Elli, Gian Eugenio Tontini, Luisa Doneda, Lorenzo Norsa, Marialaura Cuomo, Vincenza Lombardo, Alice Scricciolo, Flavio Caprioli, Andrea Costantino, Lucia Scaramella, Maurizio Vecchi
Summary: This review examines the dietary patterns and food choices of patients with inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis. The review highlights that IBD patients often avoid gluten and dairy products, but have a low compliance with the Mediterranean Diet. It emphasizes the importance of nutritional counselling in IBD patients and the need for future clinical studies to evaluate the beneficial effects of dietary recommendations in IBD management.
Article
Food Science & Technology
Alejandro Martinez-Rodriguez, Daniela Alejandra Loaiza-Martinez, Javier Sanchez-Sanchez, Jacobo A. Rubio-Arias, Fernando Alacid, Soledad Prats-Moya, Maria Martinez-Olcina, Rodrigo Yanez-Sepulveda, Pablo J. Marcos-Pardo
Summary: This study suggests that personalized gluten-free diet intervention combined with resistance exercise can significantly improve menopause-associated symptoms and mood in women with CD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Benjamin Lebwohl, Kristin E. Burke, Kerry L. Ivey, Ashwin N. Ananthakrishnan, Paul Lochhead, James M. Richter, Jonas F. Ludvigsson, Walter C. Willett, Andrew T. Chan, Hamed Khalili
Summary: Dietary gluten intake was found to have no association with the risk of Crohn's disease (CD) or ulcerative colitis (UC) in a study of 208,280 US participants. These findings provide reassurance amidst increasing concerns about gluten consumption as a trigger for chronic gastrointestinal diseases.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Alicja Ewa Ratajczak, Stefano Festa, Annalisa Aratari, Claudio Papi, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of unknown cause. Diet, especially the Mediterranean diet (MD), may play a role in the development and progression of IBD. MD can enrich beneficial bacteria in the gut and improve gut barrier function, reducing inflammation. However, adherence to MD is generally low among IBD patients, and they may avoid certain MD components due to gastrointestinal symptoms. Patients should be encouraged to adopt a healthy and well-balanced diet based on their individual tolerance.
FRONTIERS IN NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Ramit Magen-Rimon, Andrew S. Day, Ron Shaoul
Summary: This review summarizes recent reports on nutritional factors relevant to the development of inflammatory bowel disease (IBD) and also reviews data on nutritional deficiencies seen in individuals with IBD.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Immunology
Stefania De Santis, Aurelia Scarano, Marina Liso, Francesco Maria Calabrese, Giulio Verna, Elisabetta Cavalcanti, Annamaria Sila, Antonio Lippolis, Maria De Angelis, Angelo Santino, Marcello Chieppa
Summary: The health status of mother microbiota has a significant impact on the neonatal gut microbiota. Using a murine model of UC predisposition, this study evaluated the effects of maternal diet during pregnancy and lactation on offspring microbiota, indicating that a diet enriched with bioactive polyphenols from tomato can reduce dysbiosis in genetically predisposed offspring.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Edward L. Barnes, Hans H. Herfarth
Article
Gastroenterology & Hepatology
Hans Herfarth, Edward L. Barnes, John F. Valentine, John Hanson, Peter D. R. Higgins, Kim L. Isaacs, Susan Jackson, Mark T. Osterman, Kristen Anton, Anastasia Ivanova, Millie D. Long, Christopher Martin, Robert S. Sandler, Bincy Abraham, Raymond K. Cross, Gerald Dryden, Monika Fischer, William Harlan, Campbell Levy, Robert McCabe, Steven Polyak, Sumona Saha, Emmanuelle Williams, Vijay Yajnik, Jose Serrano, Bruce E. Sands, James D. Lewis
Review
Gastroenterology & Hepatology
Dominik Bettenworth, Marcus M. Muecke, Rocio Lopez, Amandeep Singh, Weiming Zhu, Feilong Guo, Toshiyuki Matsui, Theodore W. James, Hans Herfarth, Martin Goetz, Ren Mao, Satya Kurada, Jochen Hampe, Katja Matthes, John Gasdal Karstensen, Piero V. Valli, Marjolijn Duijvestein, Geert D'Haens, Vipul Jairath, Tian Bai Qiu, Nik Sheng Ding, Gerhard Rogler, Florian Rieder
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Erin M. Kim, Cara Randall, Renee Betancourt, Staci Keene, Amy Lilly, Mark Fowler, Evan S. Dellon, Hans H. Herfarth
INFLAMMATORY BOWEL DISEASES
(2020)
Letter
Gastroenterology & Hepatology
Edward L. Barnes, Bharati Kochar, Hans H. Herfarth, Rachel W. Winter, Millie D. Long, Joshua R. Korzenik, Silvia F. Quevedo, Joseph A. Galanko, Mark Koruda, Michael D. Kappelman, Robert S. Sandler
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Edward L. Barnes, Stefan D. Holubar, Hans H. Herfarth
Summary: Patients with concomitant primary sclerosing cholangitis and ulcerative colitis undergoing colectomy may have an increased risk of pouchitis. A systematic review and meta-analysis showed that patients with PSC-UC were more likely to experience pouchitis and pouch failure compared to those with UC alone. The study suggests the need for careful consideration of surgical options and further research in this patient population.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
James D. Lewis, Raymond K. Cross, Millie Long, Siddharth Singh, Hans Herfarth, Alexandra Weiss, Anna Buchner
Summary: There is a wide variation in dysplasia surveillance practices among high-volume inflammatory bowel disease providers, with only a small percentage using dye-based or virtual chromoendoscopy, or random biopsies.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Gabriel Lupu, Kimberly N. Weaver, Hans H. Herfarth, Edward L. Barnes
Summary: The retrospective analysis shows that approximately 50% of patients with chronic pouch-related disorders demonstrated clinical response within 4 weeks of vancomycin treatment. Furthermore, 76% of responders maintained clinical response at 3 and 6 months.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Brandon M. Shore, Bharati Kochar, Hans H. Herfarth, Edward L. Barnes
Summary: Due to the projected increase in the population of older patients with inflammatory bowel disease (IBD), it is important to have a better understanding of the critical issues faced by these patients. While restorative proctocolectomy with IPAA is still the preferred surgical procedure for most patients with medically refractory ulcerative colitis (UC) and UC-related dysplasia, there is limited evidence regarding surgery for older patients with UC. In particular, the outcomes of older and younger patients undergoing IPAA and the outcomes of older patients undergoing IPAA compared to those undergoing proctocolectomy with end ileostomy remain understudied but important issues.
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2022)