Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Iqbal Ahmad, Mohammad Altaf, Salim Manoharadas, Basel F. Al-Rayes, Mohammed Saeed Ali Abuhasil, Yaser Ayesh Almaroai
Summary: The study showed that green synthesized silver nanoparticles (AgNPs-MK) demonstrated significant inhibitory effects on biofilm development and quorum sensing controlled virulence factors of Gram negative bacteria, indicating their potential in addressing the issue of antimicrobial resistance.
Article
Food Science & Technology
Xiangpeng Han, Qingying Chen, Xingguo Zhang, Xiaolan Chen, Dongsheng Luo, Qingping Zhong
Summary: This study found that Lactiplantibacillus plantarum 2057 can effectively inhibit the formation of Vibrio parahaemolyticus biofilm and interfere with its adhesion ability. In addition, the extract of L. plantarum Z057 significantly reduces the biofilm biomass, metabolic activity, and various important components of V. parahaemolyticus. These findings suggest that L. plantarum 2057 could be a biocontrol strategy alternative to chemical methods against foodborne pathogens.
Article
Chemistry, Multidisciplinary
Mohammad Altaf, Mohammad Tarique Zeyad, Md Amiruddin Hashmi, Salim Manoharadas, Shaik Althaf Hussain, Mohammed Saeed Ali Abuhasil, Mohammed Abdulaziz M. Almuzaini
Summary: Most bacteria survive in nature by forming biofilms, and this study demonstrates the efficacy of green synthesized titanium dioxide nanoparticles in inhibiting and eradicating biofilms of bacterial pathogens, suggesting potential for developing novel antibiofilm agents.
Review
Chemistry, Applied
Amin Sadeghi Dousari, Bagher Amirheidari, Fatemeh Sadeghi Dousari, Mohsen Karbalaei
Summary: This article presents the investigation of different nanoparticles for the detection and effects of antibacterial, anti-biofilm, and anti-infestation assays against the human pathogen S. agalactiae.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Palwasha Khan, Amara Waheed, Muhammad Azeem, Amna Parveen, Muhammad Arfat Yameen, Jamshed Iqbal, Muhammad Ali, Shiwei Wang, Sadaf Qayyum, Awal Noor, Tatheer Alam Naqvi
Summary: This study evaluated the potential of Tagetes minuta essential oil (EO) to inhibit biofilm and related virulence factors. The EO significantly inhibited virulence factors linked with quorum sensing (QS), such as pyocyanin production, protease production, and swarming motility. It also inhibited biofilm formation, indicating that the inhibition of biofilm by EO is through the inhibition of the QS pathway. However, the EO showed limited antibacterial activity. The study confirmed that the EO interferes with the QS pathway that controls various virulence factors.
Article
Chemistry, Multidisciplinary
Palwasha Khan, Amara Waheed, Muhammad Azeem, Amna Parveen, Muhammad Arfat Yameen, Jamshed Iqbal, Muhammad Ali, Shiwei Wang, Sadaf Qayyum, Awal Noor, Tatheer Alam Naqvi
Summary: This study evaluated the potential of Tagetes minuta essential oil to inhibit biofilm formation and related virulence factors. The results showed that the essential oil significantly inhibited the virulence factors associated with quorum sensing and effectively inhibited biofilm formation.
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Iqbal Ahmad, Mohammad Altaf, Saad H. Alotaibi
Summary: The intensive use of antimicrobial agents has led to the emergence of multidrug resistance among microbial pathogens. Green synthesized gold nanoparticles can effectively inhibit virulence factors and biofilm development in bacteria, showing promise in the development of anti-infective agents.
Article
Plant Sciences
Andres G. Sierra-Quitian, Lida V. Hernandez-Moreno, Ludy C. Pabon-Baquero, Juliet A. Prieto-Rodriguez, Oscar J. Patino-Ladino
Summary: The present study demonstrates the potential of extracts and chemical constituents from Piper bogotense in inhibiting biofilm formation and quorum sensing (QS) of Pseudomonas aeruginosa. The study also highlights the effects of these constituents on virulence factors associated with QS. Compounds isolated from P. bogotense, including prenylated benzoic acids and a prenylated hydroquinone, exhibited strong inhibitory effects on violacein production and the production of virulence factors. These findings suggest that P. bogotense components could be used as an alternative method to control multidrug-resistant P. aeruginosa.
Article
Biochemistry & Molecular Biology
Kamila Korzekwa, Anna Kedziora, Bartlomiej Stanczykiewicz, Gabriela Bugla-Ploskonska, Dorota Wojnicz
Summary: The study suggests that silver nanoparticles immobilized on SiO2 or TiO2 have a beneficial inhibitory effect on biofilm formation by Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Masumeh Ziaee, Asiyeh Sheikhzadeh Takabi, Asgar Ebadollahi
Summary: In this study, Carum copticum L. essential oil-loaded nanoparticles were prepared and characterized. The mortality percentage of Rhyzopertha dominica and Tribolium confusum adults were 74 and 57% when exposed to the nanoparticles at a 1:1.25 weight ratio of chitosan to essential oil, while the essential oil caused 62 and 44% mortality on both insect species, respectively. Therefore, the nanoparticles can potentially improve the insecticidal activity of Carum copticum essential oil and facilitate the control of stored-product insect pests.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Food Science & Technology
Koudoro Yaya Alain, Alfred Ngenge Tamfu, Selcuk Kucukaydin, Ozgur Ceylan, Agbangnan Dossa Cokou Pascal, Avlessi Felicien, Sohounhloue Codjo Koko Dominique, Mehmet Emin Duru, Rodica Mihaela Dinica
Summary: The study found that gum arabica extracted from acacia plants contains various beneficial components and has good antioxidant, antimicrobial, and enzyme-inhibiting activities. These results emphasize the importance of acacia in food applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Dilek Yalcin, Ilkay Acikgoz Erkaya, Belgin Erdem
Summary: In this study, AgNPs were synthesized using Oscillatoria princeps biomass, and the synthesized AgNPs were validated and characterized. The results showed that the AgNPs synthesized from Oscillatoria princeps have the ability to inhibit biofilm formation, indicating their potential therapeutic effect on biofilm-associated infections caused by bacteria and yeasts.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rabab A. Dorgham, Mohamed N. Abd Al Moaty, Khim Phin Chong, Bassma H. Elwakil
Summary: Silver nanoparticles synthesized using molasses were found to have promising antimicrobial activity against biofilms, with molasses concentration being the main factor affecting their performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Alfred Ngenge Tamfu, Gokhan Kocak, Ozgur Ceylan, Funda Citak, Vural Butun, Huseyin Cicek
Summary: In this study, antimicrobial polymers with greater applications than traditional antibiotics were developed. The modified polymeric microparticles showed good antibiofilm activity and can be used to reduce the spread of microbial infections and resistance.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Mohammad Shavez Khan, Iqbal Ahmad, Fohad Mabood Husain, Rais Ahmad Khan, Iftekhar Hassan, Syed Ali Shahzad, Walaa AlHarbi
Summary: This study demonstrated the significant inhibitory effect of coumarin on QS-regulated virulent traits of Gram-negative bacteria, including the suppression of various virulence factors and biofilm formation. Computational studies revealed that coumarin may inhibit quorum sensing activity through multiple mechanisms.
Article
Biochemistry & Molecular Biology
Samreen, Faizan Abul Qais, Iqbal Ahmad
Summary: Multiple drug resistance (MDR) in bacteria has become a global issue, leading to reduced efficacy of antibiotics and increased therapeutic failure. This study aimed to identify potential inhibitors for the efflux pump of AcrB protein in E. coli using molecular docking. Among the 19 screened phytocompounds, chlorogenic acid showed the highest binding affinity and may serve as a promising efflux pump inhibitor in combination therapy against E. coli.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Akhlas Tarannum, Zarina Arif, Mohd Mustafa, Faizan Abul Qais, Safia Habib, Moin Uddin, Khursheed Alam
Summary: This study explores the simultaneous effect of glycation and nitroxidation on the structure, conformation, and function of albumin. The glyco-nitro-oxidized albumin showed decreased free amino acid content and decreased affinity towards cobalt. The formation of carboxymethyl lysine and 3-nitrotyrosine in glyco-nitro-oxidized albumin was confirmed. This research provides a basis for studying the role of glyco-nitro-oxidized albumin in the pathogenesis and progression of autoimmune diseases, including rheumatoid arthritis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Iftekhar Hassan, Rais Ahmad Khan, Jameel Al-Tamimi, Hossam Ebaid, Fohad Mabood Husain, Ibrahim M. Alhazza
Summary: This study aims to evaluate the comparative ameliorative potential of ternary Cu and Zn-based complexes in ceasing CCl4-induced hepatotoxic insults. Results showed significant improvement in most parameters with the Cu (II) complex. Thus, the Cu (II) complex has more substantial ameliorative potential in preventing CCl4-induced hepatotoxicity.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Energy & Fuels
Ali Alsalme, Rais Ahmad Khan, Malak Faisal Altowairqi, Nouf Abdul Rahman Almuryyi
Summary: This article reports on the simulation of FTO/TiO2/MA(3)Sb(2)I(9)/spiro-OMeTAD solar cells. The thickness of the absorber layer, hole-transport layer, or electron-transport layer was varied during the simulation process and the optimized solar cells demonstrated a high efficiency of 14.90% and an open circuit voltage of 1.41 V.
Article
Materials Science, Multidisciplinary
Arshad Iqbal, Tanveer Ahamad, Faizan Abul Qais, Nafees Ahmad, Adil Shafi, Arham Shareef Ahmed, Seema Srivastava
Summary: This study synthesized graphene oxide (GO) loaded cerium oxide (CeO2) nanocomposites using a simple sonication method from an aqueous extract of Phoenix dactylifera fruit. The nanocomposites showed spherical nanoparticles with average crystallite sizes between 6 and 12 nm. GO/CeO2 nanocomposites exhibited enhanced photocatalytic degradation efficiency and anti-biofilm activity, making them a potential solution for wastewater treatment.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Medicinal
Iftekhar Hassan, Hossam Ebaid, Ibrahim M. Alhazza, Jameel Al-Tamimi, Ahmed M. Rady
Summary: The present study investigated the potential of combining the anticancer drug 5-FU with copper and its chelating agent, disulfiram, in treating hepatocellular carcinoma in rats. The combination treatment showed significant improvement in most parameters, improving histological details and triggering apoptosis in cancer cells to a remarkable extent. Manipulating copper levels greatly enhances the antineoplastic activity of 5-FU and sensitizes cancer cells to the increased efficacy of the drug.
Article
Multidisciplinary Sciences
Zeeshan Rafi, Mohammad Hassan Baig, Fohad Mabood Husain, Suliman Yousef Alomar, Jae-June Dong, Mohd Sajid Khan
Summary: This study achieved the facile synthesis of gold nanoparticles (AuNPs) and their bioconjugation with herbal drug garcinol (G) in order to enhance the antiglycative, antidiabetic, and anticancer efficacy. The results showed that G-AuNPs were more effective in inhibiting glycation reactions and preventing the formation of early glycation adducts and AGEs. Additionally, G-AuNPs induced apoptosis in cancer cells, leading to cell death.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Manal M. Alkhulaifi, Malak M. Alosaimi, Mohd Shahnawaz Khan, Shams Tabrez, Gouse M. Shaik, Majed S. Alokail, Mohammed A. Hassan, Muawiya E. Awadalla, Fohad Mabood Husain
Summary: Lactoferrin was purified from camel milk colostrum using cation exchange chromatography and its antimicrobial potential was assessed. The purified lactoferrin showed inhibitory effects against methicillin-resistant S. aureus, S. aureus, K. pneumonia, and multidrug-resistant P. aeruginosa. The iron-free lactoferrin and hydrolyzed lactoferrin were more effective against MRSA. Scanning electron microscopy analysis revealed distortions in bacterial cells exposed to lactoferrin. The lactoferrin forms also exhibited antibiofilm activity and dose-dependent cytotoxicity against human lung cancer cells.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ibrahim M. M. Alhazza, Iftekhar Hassan, Hossam Ebaid, Jameel Al-Tamimi, Zafrul Hasan
Summary: This study investigates the therapeutic potential of zinc oxide nanoparticles (ZnO NPs) against potassium bromate (PB)-induced nephrotoxicity in Swiss albino rats, and the results demonstrate the significant ameliorative efficacy of ZnO NPs in treating PB-induced kidney toxicity.
Review
Microbiology
Asghar Ali, Andaleeb Zahra, Mohan Kamthan, Fohad Mabood Husain, Thamer Albalawi, Mohammad Zubair, Roba Alatawy, Mohammad Abid, Md Salik Noorani
Summary: This review explores the diverse applications of microbial biofilms, their clinical consequences, and alternative therapies targeting these resilient structures. The beneficial applications of microbial biofilms in wastewater treatment, bioremediation, food industries, agriculture, and biotechnology are discussed. The mechanisms of biofilm formation, clinical consequences of biofilms, and their association with antibiotic resistance, chronic infections, and medical device-related infections are highlighted. Furthermore, the potential of antimicrobial agents, such as antimicrobial peptides, quorum-sensing inhibitors, phytoextracts, and nanoparticles, in targeting biofilms is examined.
Article
Biochemistry & Molecular Biology
Sachin Kumar, Haris M. Khan, Fohad Mabood Husain, Rafiq Ahmad, Faizan Abul Qais, Mo Ahamad Khan, Mohammad Jalal, Uzma Tayyaba, Syed Ghazanfar Ali, Amardeep Singh, Mohammad Shahid, Byeong-Il Lee
Summary: Infectious diseases are a major concern for human health, and the emergence of multidrug-resistant bacteria has made this issue even more complex. In this study, silver nanoparticles synthesized using the leaf extract of a medicinal plant showed robust antibacterial and antibiofilm activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) bacteria. Electron microscopy revealed that these nanoparticles had a deleterious impact on bacterial morphology.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Multidisciplinary Sciences
Sachin Kumar, Haris M. Khan, Mo Ahamad Khan, Mohammad Jalal, Shariq Ahamad, Mohammad Shahid, Fohad Mabood Husain, Mohammed Arshad, Mohd Adil
Summary: The biogenic synthesis of silver nanoparticles using aqueous leaf extract of Phyllanthus niruri shows potential in combating drug-resistant bacterial infections by inhibiting the growth of various pathogenic bacteria and reducing their ability to form biofilms.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Environmental Sciences
Iftekhar Hassan, Jameel Al-Tamimi, Hossam Ebaid, Mohamed A. Habila, Ibrahim M. Alhazza, Ahmed M. Rady
Summary: This study investigates the role of silver nanoparticles decorated with curcumin in enhancing the efficacy of metformin and countering drug-induced hepatotoxicity in chronic diabetes. The results show that the nanoparticles can relieve oxidative stress, toxic burden, and inflammation, leading to the restoration of liver function.
Article
Plant Sciences
Mohd Aamir, V. Shanmugam, Manish Kumar Dubey, Fohad Mabood Husain, Mohd Adil, Waquar Akhter Ansari, Ashutosh Rai, Pankaj Sah
Summary: In this study, the complex interaction between Trichoderma and the tomato genome was investigated, revealing transcriptional and metabolic changes triggered by Trichoderma colonization. Gene expression profile analysis identified differentially expressed significant genes, showing a positive correlation between the host and Trichoderma. Several genes were found to be consistently significant, with some showing upregulated expression and others downregulated expression during Trichoderma-tomato interaction. Transcription factors related to systemic defense and flowering were also differentially expressed. Protein-protein interaction network analysis and Weighted Correlation Gene Network Analysis further revealed the genes associated with carbohydrate metabolism, secondary metabolite biosynthesis, and nitrogen metabolism. Overall, this study highlights the importance of Trichoderma-induced microbial priming in reprogramming the host genome for transcriptional response and understanding the complex regulatory networks in beneficial microbial interactions.
Article
Chemistry, Analytical
Theophile Niyitanga, Mohd Quasim Khan, Khursheed Ahmad, Rais Ahmad Khan
Summary: Azithromycin is a widely used and prioritized antibiotic, but its side effects can cause significant harm to humans and the environment. Therefore, developing effective and sensitive sensors to monitor the concentration of Azithromycin is crucial. In this study, a MoS2@Ti3AlC2 composite was used to fabricate an Azithromycin sensor, which exhibited excellent performance.