期刊
MEDICINAL RESEARCH REVIEWS
卷 40, 期 5, 页码 2049-2084出版社
WILEY
DOI: 10.1002/med.21698
关键词
anticancer; chalcone; drug-resistant; hybrid compounds; mechanisms of action; structure-activity relationship
资金
- National Natural Science Foundation of China [81830052, 81530053]
- Shanghai Key Laboratory of Molecular Imaging, China [18DZ2260400]
- Natural Science Foundation of Shandong Province, China [ZR2019BA015]
The continuous emergency of drug-resistant cancers and the low specificity of anticancer agents have been the major challenges in the control and treatment of cancer, making an urgent need to develop novel anticancer agents with high efficacy. Chalcones, precursors of flavonoids and isoflavonoids, exhibit structural heterogeneity and can act on various drug targets. Chalcones which demonstrated potential in vitro and in vivo activity against both drug-susceptible and drug-resistant cancers, are useful templates for the development of novel anticancer agents. Hybridization of chalcone moiety with other anticancer pharmacophores could provide the hybrids which have the potential to overcome drug resistance and improve the specificity, so it represents a promising strategy to develop novel anticancer agents. This review emphasizes the development, the mechanisms of action as well as structure-activity relationships of chalcone hybrids with potential therapeutic application for many cancers in recent 10 years.
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