Article
Agriculture, Multidisciplinary
Ying-Jun Zhou, Nuo Xu, Xiao-Chen Zhang, Yu-Yan Zhu, Shao-Wei Liu, Ya-Ning Chang
Summary: Chrysin, a natural product with minimal side effects, has been shown to effectively modulate glucose and lipid metabolism by regulating key proteins and signaling pathways, offering potential as a treatment for metabolic syndrome.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Yao Yao, Ying Yang, Huihui Wang, Zhihao Jiang, Haitian Ma
Summary: The incident of lipid metabolism disorders has increased under the undue pursuit of efficiency, which seriously threatens the health development of poultry industry. Dehydroepiandrosterone (DHEA), an important cholesterol-derived intermediate, has shown fat-reduction effect, but its mechanism is still poorly understood. This study found that DHEA effectively reduced lipid content and deposition in chicken hepatocytes stimulated by oleic acid (OA) by inhibiting lipogenesis and promoting lipolysis, and activated the AMPK-mTOR signaling pathway to prevent fat excessive accumulation.
Article
Agriculture, Dairy & Animal Science
Kun Zhang, Yan Shi, Chunli Huang, Cheng Huang, Puzhi Xu, Changming Zhou, Ping Liu, Ruiming Hu, Yu Zhuang, Guyue Li, Guoliang Hu, Xiaoquan Guo
Summary: The activation of AMPK signaling pathway in laying hen hepatocytes increases fatty acid oxidation and decreases lipid synthesis, thereby ameliorating liver steatosis.
Article
Nutrition & Dietetics
Doriana Verrelli, Luca Dallera, Massimo Stendardo, Silvia Monzani, Sebastiano Pasqualato, Marco Giorgio, Rani Pallavi
Summary: Regulating cancer cell growth through the activation of AMP-activated protein kinase (AMPK) is a commonly studied strategy for cancer treatment. This study found that hydroxycitric acid (HCA), a natural compound found in Garcinia gummi-gutta, has potent AMPK activity in chronic myelogenous leukemia (CML) cells. HCA was able to inhibit the growth of CML cells and had a direct interaction with ATP citrate lyase (ACLY) that is sensitive to HCA treatment. These findings suggest that HCA could be a potential nutraceutical approach for the treatment of CML.
Article
Cell Biology
Hongyan Ding, Yu Li, Wei Li, Huanqing Tao, Leihong Liu, Cai Zhang, Tao Kong, Shibin Feng, Jinchun Li, Xichun Wang, Jinjie Wu
Summary: The study found that EGCG can regulate hepatic lipid metabolism in canines by activating the AMPK signaling pathway and decreasing fat accumulation. Additionally, exogenous BML-275 can inhibit the effects of EGCG on lipid metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Haiting He, Yaxi Zhang, Yue Sun, Yanwei Zhang, Jingjing Xu, Yuzhen Yang, Jihua Chen
Summary: The study found that folic acid can reduce body fat percentage in obese mice, alleviate related metabolic disorders, and improve symptoms of osteoporosis. Folic acid modulates lipid metabolism and oxidative stress responses by activating the AMPK signaling pathway, thus alleviating HFD-induced osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu, Yana Li
Summary: This study found that VEGFB can participate in lipid metabolism and insulin resistance in NAFLD through the AMPK signaling pathway, further confirming the importance of VEGFB in the pathogenesis of fatty liver disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Jiaqi Tian, Junxia Li, Haoyu Yin, Lan Ma, Jing Zhang, Qingfeng Zhai, Shuyin Duan, Lin Zhang
Summary: The study demonstrated that exposure to silica nanoparticles (SiNPs) could induce reproductive toxicity in female by dysregulating certain genes, impairing cellular functions, inducing apoptosis, and inflammation. These findings contribute to a better understanding of the impact of SiNPs on female reproductive system.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Jie Sun, Yalan Pan, Xiaofeng Li, Lining Wang, Mengmin Liu, Pengcheng Tu, Chengjie Wu, Jirimutu Xiao, Qiuge Han, Weiwei Da, Yong Ma, Yang Guo
Summary: Quercetin has been found to play a role in disease prevention and health promotion, and recent studies have shown its potential in improving bone health. This study investigated the effects of quercetin on osteoporosis induced by androgen deprivation therapy in mice. The results showed that quercetin improved bone microstructure, bone strength, and muscle mass, and regulated glucose and lipid metabolism. The beneficial effects of quercetin may be attributed to its modulation of the GPCR6A/AMPK/mTOR signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu
Summary: The study revealed that DBP can induce fatty liver disease by activating the PPAR alpha signaling pathway and inhibiting AMPK phosphorylation. The results indicated that DBP affects protein expression, leading to hyperlipidemia and abnormal liver function, which can be alleviated through the PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhihao Jiang, Huihui Wang, Ying Yang, Yao Yao, Haitian Ma
Summary: Excessive fat accumulation in broiler chickens threatens the poultry industry and consumers' health. Dietary supplements with bioactive ingredients, such as genistein, can effectively reduce fat deposition. This study found that genistein regulates lipid metabolism-related factors expression in chicken hepatocytes, leading to decreased lipid droplets accumulation.
Article
Biochemistry & Molecular Biology
Juan Li, Hanxiang Zhan, Yidan Ren, Maoxiao Feng, Qin Wang, Qinlian Jiao, Yuli Wang, Xiaoyan Liu, Shujun Zhang, Lutao Du, Yunshan Wang, Chuanxin Wang
Summary: This study found that SIRT4 activates the phosphorylation of p53 protein and promotes autophagy in PDAC by suppressing glutamine metabolism, thereby inhibiting tumor growth and progression.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Medicine, Research & Experimental
Qian Li, Ying Yang, Huihui Wang, Zhihao Jiang, Haitian Ma
Summary: Genistein improves glucose metabolism by activating the GPER-mediated signaling pathway, providing a theoretical basis for its use as a nutritional supplement to treat metabolic disorders and related diseases.
Article
Medicine, Research & Experimental
Yiping Li, Yang Liu, Zhiwei Chen, Kaiyue Tang, Lili Yang, Yuwei Jiang, Jue Wang, Ping Huang, Jianyi Wang, Peiyong Zheng, Haiyan Song
Summary: In this study, researchers found that Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, can improve lipid accumulation in hepatocytes induced by free fatty acids and has a therapeutic effect on Non-alcoholic fatty liver disease (NAFLD). The results showed that PPD can reduce liver weight, serum aminotransferase levels, hepatosteatosis, and inflammatory cell infiltration in liver tissues of mice with NAFLD. PPD also improves lipid accumulation in hepatocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Physiology
Mahdi Ahsan, Lea Garneau, Celine Aguer
Summary: Myokines are peptides and proteins secreted by skeletal muscle cells, which can influence energy metabolism via AMPK signalling. Understanding how Myokines affect AMPK signalling and their mutual influence is important for better elucidation of metabolic regulation during exercise and at rest. This review covers the latest research on the relationship between AMPK signalling and Myokines within skeletal muscles.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.