Article
Engineering, Biomedical
Cosmin Butnarasu, Paola Petrini, Francesco Bracotti, Livia Visai, Giuseppe Guagliano, Alessandra Fiorio Pla, Ettore Sansone, Sara Petrillo, Sonja Visentin
Summary: Mucosomes, a novel class of glycosylated nanoparticles based on mucin, are introduced to overcome the complex barrier of mucus during transmucosal drug delivery. They improve drug absorption and residence time on mucosal tissues and can be loaded with different physicochemical properties. Mucosomes exhibit good mucoadhesive properties and have shown no adverse effects in in vitro and in vivo tests.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Bhavana Valamla, Pradip Thakor, Rashmi Phuse, Mayuri Dalvi, Pratik Kharat, Ankaj Kumar, Dilip Panwar, Shashi Bala Singh, Pastorin Giorgia, Neelesh Kumar Mehra
Summary: Vaginal drug delivery is effective for treating and preventing various conditions, including infections and cancer. By improving drug absorption and providing sustained release and precise targeting, it enhances the efficacy of prophylactic and therapeutic treatments. This review summarizes the role of the mucosal vaginal barrier in drug delivery, with a focus on mucoadhesive drug delivery systems and their applications for vaginal tissue.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Liangbo Chen, Feng Wu, Yan Pang, Dan Yan, Siyi Zhang, Fangjie Chen, Nianxuan Wu, Danni Gong, Jinyao Liu, Yao Fu, Xianqun Fan
Summary: The study demonstrates the formation of a durable and protective therapeutic nanocoating on the ocular surface by instilling biomimetic drug-loaded nanoparticles, which can specifically bind to ocular epithelium fibronectin and improve the stability of tear film. This approach shows therapeutic benefits in mouse and rabbit models of dry eye disease, indicating the potential of therapeutic nanocoating to treat eye diseases.
Review
Pharmacology & Pharmacy
Vishal Puri, Vishav Prabhjot Kaur, Arti Singh, Charan Singh
Summary: This article discusses the role, composition, and properties of mucus in the human body, as well as the factors affecting mucosal barrier properties. It emphasizes the importance of designing mucoadhesive delivery systems through surface modification to achieve targeted and sustained drug delivery, enhance therapeutic efficacy, and reduce side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Rong Yan, Lai Xu, Quhe Wang, Zheng Wu, Hua Zhang, Li Gan
Summary: The study compared the mucoadhesion of cationic nanoparticles and mucous permeability of MPPs on ocular bioavailability. Both cationic and MPP nanosuspensions showed effective delivery of CsA to anterior ocular tissues, with the cationic nanosuspension achieving relatively higher bioavailability. The results suggest that cationic nanosuspension could be a promising ocular drug delivery system.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Aditya Josyula, Revaz Omiadze, Kunal Parikh, Pranjali Kanvinde, Matthew B. Appell, Pratikkumar Patel, Hiwa Saeed, Yogesh Sutar, Nicole Anders, Ping He, Peter J. McDonnell, Justin Hanes, Abhijit A. Date, Laura M. Ensign
Summary: This study describes an ion-pairing approach to creating MOX-PAM NS for the treatment of ocular infections, significantly increasing ocular drug absorption and demonstrating good prophylactic and treatment efficacy in a rat model.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Neha Shrestha, Yining Xu, Julien R. C. Prevost, Fiona McCartney, David Brayden, Raphael Frederick, Ana Beloqui, Veronique Preat
Summary: Nanoparticle-based oral drug delivery systems have the potential to target inflamed regions in the gastrointestinal tract. This study developed mucus-penetrating nanoparticles to encapsulate monoclonal antibodies for the treatment of inflammatory bowel disease. The results showed that the length of the PEG chain had a significant impact on the efficacy of the nanoparticles in vivo.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Eriko Yamazoe, Jia-You Fang, Kohei Tahara
Summary: Densely polyethylene glycol-modified liposomes showed mucus permeability and improved oral absorption compared to mucoadhesive liposomes. The in vivo and in vitro experiments revealed that modifying liposomes with PEG increased oral absorption but excessive PEGylation decreased absorption. Incorporating spermine as an absorption enhancer in PEGylated liposomes showed the highest in vivo absorption of the model peptide drug tested.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mithun Saha, Diti Rani Saha, Tahamina Ulhosna, Shazid Md Sharker, Md Hasanuzzaman Shohag, Muhammad Saiful Islam, Swapan K. Ray, G. M. Sayedur Rahman, Hasan Mahmud Reza
Summary: The study successfully developed resveratrol-loaded mucoadhesive lecithin/chitosan nanoparticles to improve drug retention in the eye. Through risk assessments and optimized designs, the formulated nanoparticles had optimal characteristics such as 163.3 nm particle size, 97.03% entrapment efficiency, and zero-order release kinetics with an R2 value of 0.9897.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Wufa Fan, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li, Youqing Shen
Summary: The study introduces a novel polymeric micelle that can penetrate mucus layer and be absorbed by villi, efficiently delivering anticancer drugs to tumors with improved therapeutic efficacy.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Shahla Mirzaeei, Shiva Taghe, Raid G. Alany, Ali Nokhodchi
Summary: The present study aimed to enhance the delivery of erythromycin (ERY) by developing modified-release inserts containing ERY-loaded nanoparticles and mucoadhesive films. The developed inserts showed prolonged release profiles in vitro and in vivo, exhibited antibacterial efficacy, and did not cause irritation to the rabbit's eye. These findings suggest that nanoparticle-containing, mucoadhesive films could be a promising approach for topical ocular delivery of ERY.