Article
Engineering, Biomedical
Neha Shrestha, Yining Xu, Julien R. C. Prevost, Fiona McCartney, David Brayden, Raphael Frederick, Ana Beloqui, Veronique Preat
Summary: Nanoparticle-based oral drug delivery systems have the potential to target inflamed regions in the gastrointestinal tract. This study developed mucus-penetrating nanoparticles to encapsulate monoclonal antibodies for the treatment of inflammatory bowel disease. The results showed that the length of the PEG chain had a significant impact on the efficacy of the nanoparticles in vivo.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Wufa Fan, Qiuyu Wei, Jiajia Xiang, Yisi Tang, Quan Zhou, Yu Geng, Yanpeng Liu, Rui Sun, Lei Xu, Guowei Wang, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Tao Xie, Zichen Li, Youqing Shen
Summary: The study introduces a novel polymeric micelle that can penetrate mucus layer and be absorbed by villi, efficiently delivering anticancer drugs to tumors with improved therapeutic efficacy.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Onyinye Uwaezuoke, Lisa C. Du Toit, Pradeep Kumar, Naseer Ally, Yahya E. Choonara
Summary: This study investigated the potential use of transferosomes for delivering cyclosporine A to the eye. Linoleic acid was found to improve the stability and size of the transferosomes. Tween(R)-based formulation was preferred due to its lower toxicity profile. The prepared transferosomes showed significant drug release and adequate corneal permeability, remaining stable for four months at low temperature.
Article
Chemistry, Physical
Twana Mohammed M. Ways, Sergey K. Filippov, Samarendra Maji, Mathias Glassner, Michal Ceglowski, Richard Hoogenboom, Stephen King, Wing Man Lau, Vitaliy V. Khutoryanskiy
Summary: Transmucosal administration has many advantages for drug delivery, such as avoiding first pass metabolism, providing rapid onset of action, and being a non-invasive route. However, the mucus gel layer on mucosal surfaces acts as a protective barrier and inhibits the diffusion of drugs, reducing their efficacy. The design of mucus-penetrating nanoparticles can overcome this barrier and improve therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Liangbo Chen, Feng Wu, Yan Pang, Dan Yan, Siyi Zhang, Fangjie Chen, Nianxuan Wu, Danni Gong, Jinyao Liu, Yao Fu, Xianqun Fan
Summary: The study demonstrates the formation of a durable and protective therapeutic nanocoating on the ocular surface by instilling biomimetic drug-loaded nanoparticles, which can specifically bind to ocular epithelium fibronectin and improve the stability of tear film. This approach shows therapeutic benefits in mouse and rabbit models of dry eye disease, indicating the potential of therapeutic nanocoating to treat eye diseases.
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Article
Biophysics
Diego Salas Sanzana, Emilia Flores Faundez, Jaime Melendez, Marco Soto-Arriaza
Summary: The functionalization of liposomes with snake venom phospholipase A2 peptides has been found to enhance the encapsulation and cytotoxicity of doxorubicin, leading to improved antitumor efficacy in HeLa cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Polymer Science
Md Habban Akhter, Irfan Ahmad, Mohammad Y. Alshahrani, Alhanouf I. Al-Harbi, Habibullah Khalilullah, Obaid Afzal, Abdulmalik S. A. Altamimi, Shehla Nasar Mir Najib Ullah, Abhijeet Ojha, Shahid Karim
Summary: Topical drug instillation is the preferred route for treating ocular ailments due to its noninvasive and convenient nature. However, the physiological barriers in the eye limit the drug availability. Innovative drug delivery systems, such as nanotechnology platforms, have been developed to overcome these barriers and improve drug bioavailability in ocular tissue. The rational design of ocular therapeutic systems is crucial for enhancing drug concentration and permeation in specific areas of the eye.
Article
Pharmacology & Pharmacy
Randall A. Meyer, G. Patrick Hussmann, Norman C. Peterson, Jose Luis Santos, Anthony D. Tuesca
Summary: LPH nanocarriers show great potential as vehicles for mRNA delivery and expression in tissues, with the composition of LPH and route of administration influencing tissue expression and longevity of protein expression.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Simise S. Sikhondze, Pedzisai A. Makoni, Roderick B. Walker, Sandile M. M. Khamanga
Summary: In this study, a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) for ocular delivery were developed to improve the residence time and release of the drug in the eye, which may reduce patient non-adherence.
Article
Chemistry, Multidisciplinary
Farzin Firozian, Zahra Arabkhani, Mohammad Mehdi Mahboobian, Mojdeh Mohammadi, Gholamabbas Chehardoli
Summary: The study developed a cationic dextran stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer as a drug carrier to deliver indomethacin to cornea tissues. The prepared polymeric micelles showed sustained drug release and improved penetration of indomethacin into cornea tissues.
Article
Chemistry, Multidisciplinary
Aharon Azagury, Cameron Baptista, Kosta Milovanovic, Hyeseon Shin, Peter Morello, James Perez-Rogers, Victoria Goldenshtein, Travis Nguyen, Arianna Markel, Soham Rege, Stephanie Hojsak, Alexander Perl, Carder Jones, Megan Fife, Stacia Furtado, Edith Mathiowitz
Summary: Decades of research have not reached a consensus on the properties that produce effective oral drug delivery systems using nanoparticles. This study proposes a mechanism involving biocoating to explain the behavior of nanoparticles in vivo, which can alter their surface properties and affect their systemic uptake. Coating nanoparticles with mucus is found to increase their mucosal diffusion rate and promote high systemic uptake.