Article
Cardiac & Cardiovascular Systems
Michele Mondoni, Rocco Francesco Rinaldo, Paolo Solidoro, Fabiano Di Marco, Filippo Patrucco, Stefano Pavesi, Andrea Baccelli, Paolo Carlucci, Dejan Radovanovic, Pierachille Santus, Federico Raimondi, Sergio Vedovati, Letizia Corinna Morlacchi, Francesco Blasi, Giovanni Sotgiu, Stefano Centanni
Summary: Lung transplantation is an important treatment option for end-stage lung diseases, and interventional pulmonology techniques, mainly bronchoscopy, play a key role in the whole process. This review focused on the indications, contraindications, performance characteristics, and safety profile of interventional pulmonology techniques in lung transplantation. Bronchoscopy is useful in donor evaluation and surveillance for early rejection, infections, and airways complications. Various techniques, including biopsy and endoscopic interventions, are employed in the diagnosis and management of complications.
RESPIRATORY MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sharath K. Bhagavatula, Li Li, Guillermo J. Tearney
Summary: Interventional photoacoustic imaging (iPAI) has the potential to improve needle steering, target detection, and tissue assessment during minimally invasive procedures by enabling high precision imaging depth, spatial resolution, and visualization field in various biological tissues encountered in clinical practice. The experimental results strongly support further development of clinical iPAI systems for potential translation into clinical settings.
Review
Medicine, General & Internal
Chiara Floridi, Michaela Cellina, Giovanni Irmici, Alessandra Bruno, Nicolo Rossini, Alessandra Borgheresi, Andrea Agostini, Federico Bruno, Francesco Arrigoni, Antonio Arrichiello, Roberto Candelari, Antonio Barile, Gianpaolo Carrafiello, Andrea Giovagnoni
Summary: Interventional oncology (IO) procedures are highly popular in interventional radiology (IR) and are crucial for the diagnosis, treatment, and supportive care of cancer patients. Vascular approaches involve embolization and direct injection of chemotherapeutics into tumor-feeding vessels, while non-vascular approaches include percutaneous image-guided biopsies and various ablation techniques.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Georgia Tsoumakidou, Sarah Saltiel, Nicolas Villard, Rafael Duran, Jean-Yves Meuwly, Alban Denys
Summary: Precise marking of lesions using image-guided techniques is crucial for successful surgical excision, with indications including lung nodules, liver metastasis, and other non-palpable lesions. Image-guided lesion marking can improve treatment outcomes.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Article
Allergy
Sara M. Mensink-Bout, Susana Santos, Johan C. de Jongste, Vincent W. V. Jaddoe, Liesbeth Duijts
Summary: This study found that higher diastolic blood pressure at age 6 was associated with higher forced vital capacity at age 10, while elevated CRP concentrations above the 75th percentile at both ages 6 and 10 were related to lower FVC. No consistent associations were observed with other cardio-metabolic risk factors. Further investigation is needed to understand the underlying mechanisms and long-term effects of these associations.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Justyna Blach, Malgorzata Frak, Pawel Krawczyk, Juliusz Pankowski, Adam Pankowski, Jaroslaw Buczkowski, Artur Szlubowski, Jan Siwiec, Piotr Krudys, Marek Michnar, Robert Kieszko, Janusz Milanowski
Summary: Bronchoscopy is crucial in diagnosing various lung diseases but has limitations. The effectiveness of EBUS-TBNA and endobronchial forceps biopsy in diagnosing lung cancer is strongly influenced by tumor localization and cancer type.
Article
Computer Science, Theory & Methods
Robert Hertel, Rachid Benlamri
Summary: This literature review provides an overview of current deep learning methods used in medical imaging AI research to tackle lung imaging problems related to COVID-19. Due to similar imaging characteristics, distinguishing COVID-19 from other pulmonary infections is challenging. Several innovative solutions have been proposed to assist healthcare providers, but the lack of a comprehensive survey makes it difficult to determine promising approaches. This survey reviews recent deep learning techniques for diagnosing and predicting outcomes of COVID-19 patients, categorizing them based on imaging features, system purpose, deep learning techniques, core issues, and challenges.
ACM COMPUTING SURVEYS
(2023)
Article
Critical Care Medicine
John Oppenheimer, Nicola A. Hanania, Rekha Chaudhuri, Hironori Sagara, Zelie Bailes, Andrew Fowler, Guy Peachey, Emilio Pizzichini, David Slade
Summary: This study examines the agreement between home and clinic spirometry in patients with uncontrolled asthma. The results suggest that home spirometry is less consistent and lacks agreement with clinic spirometry.
Article
Medicine, General & Internal
Timothy Howarth, Daniel Gahreman, Helmi Ben Saad, Lai Ng, Subash S. Heraganahally
Summary: This study evaluated the correlation between spirometry indices and chest radiology (X-ray and CT) findings in Indigenous Australians. It was found that Indigenous Australians tend to show restrictive impairment in the absence of radiological evidence, but mixed and obstructive impairments were common in the presence of airway disease. Therefore, spirometry in conjunction with chest radiology should be used to assess airway diseases in this population.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Allergy
Sara M. Mensink-Bout, Marc R. Jahangir, Johan C. de Jongste, Hein Raat, Vincent W. V. Jaddoe, Liesbeth Duijts
Summary: Adolescents with lower physical fitness have poorer lung function and higher risk of asthma, while those with longer screen time have lower lung capacity.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Alfons Torrego, Felix J. Herth, Ana M. Munoz-Fernandez, Luis Puente, Nicola Facciolongo, Stephen Bicknell, Mauro Novali, Stefano Gasparini, Martina Bonifazi, Keertan Dheda, Felipe Andreo, Praha Votruba, David Langton, Javier Flandes, David Fielding, Peter Bonta, Dirk Skowasch, Christian Schulz, Kaid Darwiche, Edmund McMullen, G. Mark Grubb, Robert Niven
Summary: Bronchial thermoplasty (BT) is an effective device-based treatment for severe asthma patients not well controlled with standard medications. The Bronchial Thermoplasty Global Registry (BTGR) collected real-world data and showed sustained improvement in clinical outcomes and reduced asthma medication usage in a 2-year follow-up. This further supports the benefits of BT in improving asthma control, as seen in other trials and registries.
Review
Medicine, General & Internal
Paolo Marra, Ludovico Dulcetta, Francesco Saverio Carbone, Riccardo Muglia, Giuseppe Muscogiuri, Maurizio Cheli, Lorenzo D'Antiga, Michele Colledan, Stefano Fagiuoli, Sandro Sironi
Summary: This article discusses the diagnostic and interventional imaging techniques for portal vein thrombosis (PVT), with a focus on the pediatric population. It provides a comprehensive review based on a large series of congenital and acquired PVT cases, and describes various diagnostic and treatment methods. The article enriches the description by including original series of pictorial imaging findings.
Article
Respiratory System
Anna Guyatt, Catherine John, Alexander T. Williams, Nick Shrine, Nicola F. Reeve, Ian Sayers, Ian Hall, Louise Wain, Nuala Sheehan, Frank Dudbridge, Martin D. Tobin
Summary: This study investigated the causal relationship between eosinophils and various respiratory phenotypes. The findings suggest a potential causal link between elevated eosinophils and ACO, moderate-to-severe asthma, and reduced lung function. However, the heterogeneity of the results calls for caution, as other mechanisms may also contribute to respiratory health impairment.
Article
Critical Care Medicine
Omar S. Usmani, MeiLan K. Han, David A. Kaminsky, James Hogg, Josephine Hjoberg, Naimish Patel, Megan Hardin, Christina Keen, Stephen Rennard, Francois-Xavier Ble, Mary N. Brown
Summary: Identification of pathologic changes in early and mild obstructive lung disease has highlighted the importance of small airways in contributing to symptoms. However, current therapies target symptoms and physiological changes rather than underlying causes of airflow disruption. Newer functional and imaging techniques allow for better assessment of small airways dysfunction, but gaps in understanding remain regarding the role of small airways dysfunction in early disease.
Article
Engineering, Biomedical
Martijn M. A. Dietze, Britt Kunnen, Marnix G. E. H. Lam, Hugo W. A. M. de Jong
Summary: The study aimed to evaluate the performance of a respiratory motion compensation technique in phantom experiments for fluoroscopy-guided interventional procedures. The results demonstrated that motion compensation improved the visual quality of nuclear projections and SPECT reconstructions, leading to a significant reduction in mean error in activity recovery.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Puja Kohli, Vanessa J. Kelly, Kathryn A. Hibbert, Bjorn Corleis, Mamary Kone, Josalyn L. Cho, Doreen DeFaria-Yeh, Douglas S. Kwon, Benjamin D. Medoff, R. Scott Harris, Tilo Winkler
Summary: In this study, researchers used PET/CT technology to examine 46 smokers and non-smokers, including 23 with known HIV infection. The results showed that non-smokers living with HIV had more prominent abnormalities in pulmonary perfusion compared to the control group, suggesting similarities to smokers.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Immunology
Rod A. Rahimi, Andrew D. Luster
TRENDS IN IMMUNOLOGY
(2020)
Article
Oncology
Dexter P. Mendoza, Puja Kohli, John W. Nance, Ramandeep Singh, Josalyn Cho, Jason Griffith, R. Scott Harris, Vanessa J. Kelly, Andrew D. Luster, Benjamin Medoff, Subba R. Digumarthy
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Lucas D. Faustino, Jason W. Griffith, Rod A. Rahimi, Keshav Nepal, Daniel L. Hamilos, Josalyn L. Cho, Benjamin D. Medoff, James J. Moon, Dario A. A. Vignali, Andrew D. Luster
Article
Cell Biology
Shannon K. Bromley, Hasan Akbaba, Vinidhra Mani, Rut Mora-Buch, Alexandra Y. Chasse, Andrea Sama, Andrew D. Luster
Article
Cell Biology
Benedict D. Michael, Laura Bricio-Moreno, Elizabeth W. Sorensen, Yoshishige Miyabe, Jeffrey Lian, Tom Solomon, Evelyn A. Kurt-Jones, Andrew D. Luster
Article
Critical Care Medicine
Jehan Alladina, Sean D. Levy, Josalyn L. Cho, Kelsey L. Brait, Sowmya R. Rao, Alexander Camacho, Kathryn A. Hibbert, R. Scott Harris, Benjamin D. Medoff, James L. Januzzi, B. Taylor Thompson, Ednan K. Bajwa
Summary: The study suggests that elevations in sST2 concentrations in patients with AHRF may indicate ongoing lung injury and better predict patient outcomes. IL-6 concentrations did not correlate with outcomes. Therefore, using sST2 concentrations to guide ventilator management may be more accurate than traditional measures.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Christoph Muus, Malte D. Luecken, Gokcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smillie, Karthik A. Jagadeesh, Elizabeth Thu Duong, Evgenij Fiskin, Elena Torlai Triglia, Meshal Ansari, Peiwen Cai, Brian Lin, Justin Buchanan, Sijia Chen, Jian Shu, Adam L. Haber, Hattie Chung, Daniel T. Montoro, Taylor Adams, Hananeh Aliee, Samuel J. Allon, Zaneta Andrusivova, Ilias Angelidis, Orr Ashenberg, Kevin Bassler, Christophe Becavin, Inbal Benhar, Joseph Bergenstrahle, Ludvig Bergenstrahle, Liam Bolt, Emelie Braun, Linh T. Bui, Steven Callori, Mark Chaffin, Evgeny Chichelnitskiy, Joshua Chiou, Thomas M. Conlon, Michael S. Cuoco, Anna S. E. Cuomo, Marie Deprez, Grant Duclos, Denise Fine, David S. Fischer, Shila Ghazanfar, Astrid Gillich, Bruno Giotti, Joshua Gould, Minzhe Guo, Austin J. Gutierrez, Arun C. Habermann, Tyler Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Yan Hu, Alok Jaiswal, Lu Ji, Peiyong Jiang, Theodoros S. Kapellos, Christin S. Kuo, Ludvig Larsson, Michael A. Leney-Greene, Kyungtae Lim, Monika Litvinukova, Leif S. Ludwig, Soeren Lukassen, Wendy Luo, Henrike Maatz, Elo Madissoon, Lira Mamanova, Kasidet Manakongtreecheep, Sylvie Leroy, Christoph H. Mayr, Ian M. Mbano, Alexi M. McAdams, Ahmad N. Nabhan, Sarah K. Nyquist, Lolita Penland, Olivier B. Poirion, Sergio Poli, CanCan Qi, Rachel Queen, Daniel Reichart, Ivan Rosas, Jonas C. Schupp, Conor Shea, Xingyi Shi, Rahul Sinha, Rene Sit, Kamil Slowikowski, Michal Slyper, Neal P. Smith, Alex Sountoulidis, Maximilian Strunz, Travis B. Sullivan, Dawei Sun, Carlos Talavera-Lopez, Peng Tan, Jessica Tantivit, Kyle J. Travaglini, Nathan R. Tucker, Katherine A. Vernon, Marc H. Wadsworth, Julia Waldman, Xiuting Wang, Ke Xu, Wenjun Yan, William Zhao, Carly G. K. Ziegler
Summary: Our study reveals that cell-type-specific expression patterns of ACE2, TMPRSS2, and CTSL are associated with the pathogenesis of COVID-19. Factors such as age, sex, and smoking status are linked to the expression of viral entry genes in respiratory cell populations, suggesting potential therapeutic targets for intervention. The integrated analysis of single-cell and single-nucleus transcriptomics studies highlights coexpression patterns of SARS-CoV-2 viral entry genes across different human tissues.
Article
Multidisciplinary Sciences
Abigail E. Schiff, Alice H. Linder, Shillah N. Luhembo, Stephanie Banning, Martin J. Deymier, Thomas J. Diefenbach, Amy K. Dickey, Athe M. Tsibris, Alejandro B. Balazs, Josalyn L. Cho, Benjamin D. Medoff, Gerhard Walzl, Robert J. Wilkinson, Wendy A. Burgers, Bjoern Corleis, Douglas S. Kwon
Summary: The study found that T-tropic HIV exists in alveolar macrophages (AMs) of HIV-infected individuals, entering macrophages through contact with infected CD4+T cells, leading to AM infection. Despite the low efficiency of cell-free infection in macrophages, the CD4+T cell-dependent entry of HIV helps explain the presence of HIV in AMs.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bjorn Corleis, Josalyn L. Cho, Samantha J. Gates, Alice H. Linder, Amy Dickey, Antonella C. Lisanti-Park, Abigail E. Schiff, Musie Ghebremichael, Puja Kohli, Tilo Winkler, R. Scott Harris, Benjamin D. Medoff, Douglas S. Kwon
Summary: HIV-1 infection and smoking can lead to an accumulation of CD8(+) T cells within the airway mucosa, affecting the progression of COPD in at-risk patients.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Engineering, Biomedical
Matthew B. Applegate, Robert Amelard, Carlos A. Gomez, Darren Roblyer
Summary: The study introduces a new high-speed FD-DOS instrument that can compute chromophore concentrations in real-time, demonstrating accurate measurements and precise instrument positioning. The visualization methodology is proven to be equivalent to a standard interpolation approach, with successful in vivo results displaying superficial vasculature and surface contrast in a healthy human breast.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Josalyn L. Cho, Raul Villacreses, Prashant Nagpal, Junfeng Guo, Alejandro A. Pezzulo, Andrew L. Thurman, Nabeel Y. Hamzeh, Robert J. Blount, Spyridon Fortis, Eric A. Hoffman, Joseph Zabner, Alejandro P. Comellas
Summary: This study found that survivors of COVID-19 may experience small airways disease independently of the severity of their initial infection. The degree of air trapping in patients was correlated with the residual volume-to-total lung capacity ratio. The long-term consequences of these findings remain unknown.
Article
Biochemistry & Molecular Biology
Rod A. Rahimi, Josalyn L. Cho, Claudia Jakubzick, Shabaana A. Khader, Bart N. Lambrecht, Clare M. Lloyd, Ari B. Molofsky, Sebastien Talbot, Catherine A. Bonham, Wonder P. Drake, Anne Sperling, Benjamin D. Singer
Summary: The mammalian airways and lungs are constantly exposed to various inhaled particles, allergens, and pathogens. The immune system plays a crucial role in protecting against respiratory pathogens, but an unbalanced immune response during respiratory infections can hinder pathogen clearance and cause immune-related diseases. Understanding the complex network of cells involved in sensing and responding to inhaled antigens is essential for developing effective mucosal vaccines and managing inflammatory pulmonary diseases. The American Thoracic Society has formed a working group to advance the study of lung immunology and improve human health.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Critical Care Medicine
Garth W. Garrison, Josalyn L. Cho, Jane C. Deng, Erin Camac, Scott Oh, Krishna Sundar, Janelle Baptiste, Guang-Shing Cheng, Jose De Cardenas, Codi Fitzgerald, Jamie Garfield, Ngoc-Tram Ha, Van K. Holden, Oisin O'Corragain, Sahil Patel, Max T. Wayne, Jakob McSparron, Tisha Wang, Basak Coruh, Margaret M. Hayes, Elizabeth Guzman, Colleen L. Channick
Summary: The 2021 American Thoracic Society Core Curriculum focuses on lung cancer, including risks, prevention, screening, therapeutics, and associated pulmonary toxicities. Tobacco smoking remains the primary risk factor, but exposure to other substances also contributes to the disease burden. Evaluation of lung nodules relies on clinical and radiographic features to estimate cancer probability.
Meeting Abstract
Critical Care Medicine
J. Alladina, T. Kooistra, R. A. Rahimi, D. Hamilos, A. Luster, B. D. Medoff, J. L. Cho
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)