Article
Materials Science, Multidisciplinary
Wen Hou, Jiaxin Guo, Jiawei Liu, Yanan Zhao, Wenying Wei, Dan Shu, Honglian Dai
Summary: Vascularisation and mineralisation are essential for bone repair materials. Introducing magnesium ions into calcium phosphate-based materials can enhance their angiogenic and mineralising capabilities. The study found that calcium-magnesium phosphate biphasic microspheres showed the best promotion effect on the attachment, proliferation, and directed differentiation of bone marrow mesenchymal stromal cells (BMSCs) and human umbilical vein cells (HUVECs).
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Lila A. Al-Khattaby, Islam E. Soliman, Mohamed A. Aboelnasr, Samah S. Eldera
Summary: BCP/Chitosan composites were evaluated for reinforcement in vitro bone regeneration. The addition of BCP improved the apatite-forming ability, bioactivity, and biomineralization of the composites. The strong interaction between BCP and the Cs matrix improved the mechanical stability of the composite. BCP/Chitosan composites showed positive effects on cell viability and proliferation of normal human osteocyte cells.
NANOTECHNOLOGY REVIEWS
(2023)
Article
Chemistry, Physical
Jinjie Wu, Cong Feng, Menglu Wang, Hongfeng Wu, Xiangdong Zhu, Xiangfeng Li, Xuening Chen, Xingdong Zhang
Summary: This study investigated the effects of biphasic calcium phosphate (BCP) ceramics with different whiskered surfaces on macrophage polarization and functional status. The results showed that BCP ceramics with short and hollow whiskers (BCP-HW) were more conducive to protein adsorption and macrophage elongation compared to those with long and solid whiskers (BCP-W). BCP-HW ceramics down-regulated the expression of M1 macrophage markers and promoted the expression of M2 macrophage markers and growth factors. The conditioned medium derived from the co-culture of macrophages and whiskered ceramics could promote the expression of bone markers in pre-osteoblasts. In an intramuscular implantation model, BCP-HW ceramics drove the switch of macrophages to the M2 phenotype and induced ectopic bone formation.
Article
Chemistry, Multidisciplinary
Xiaoyan Chen, Guangsheng Du, Shuting Bai, Liu Dijia, Chenglong Li, Yingying Hou, Yuandong Zhang, Zhirong Zhang, Tao Gong, Yao Fu, Massimo Bottini, Xun Sun
Summary: The study aimed at exploring the therapeutic effects and tolerogenic mechanism of a novel tolerogenic polypeptide vaccine, showing synergistic effects on regulatory T cells, promotion of IL-10 secretion, reduction of pro-inflammatory cytokines, and antibodies in experimental arthritis. This work could shed light on the development of tolerogenic therapeutics as novel immunotherapies for rheumatoid arthritis.
Article
Chemistry, Applied
Zhao Wang, Junfeng Su, Amjad Ali, Wenshuo Yang, Ruijie Zhang, Yifei Li, Lingfei Zhang, Jiawei Li
Summary: This research evaluates chitosan and carboxymethyl chitosan as polysaccharides that mimic the role of bacterial extracellular polymeric substance in biomineralization. Carboxymethyl chitosan demonstrated higher calcium precipitation efficiency and the nucleation of calcium carbonate was triggered by the binding of different functional groups on the polysaccharides. The study also conducted experiments on polysaccharide-mediated biomineralization, showing improved calcium precipitation efficiency with the addition of carboxymethyl chitosan. The findings provide insights into the biomineralization mechanism and strategies for enhancing MICP technology.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Kehan Deng, Zhixiao Liu, Wenxufe Dou, Qi Cai, Wei Ma, Shaohai Wang
Summary: This study explored the osteogenesis effect of BCP material derived from butterfish bones in vivo and in vitro. The results showed that the material had good biocompatibility, osteoconductivity, and osteoinductivity, making it a promising option for bone graft substitutes.
FRONTIERS IN MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yonggang Zhang, Jiaping Li, Mohammad Soleimani, Francesca Giacomini, Heiner Friedrich, Roman Truckenmuller, Pamela Habibovic
Summary: A biphasic calcium phosphate (BCP) sponge with interconnected porous structure and unique properties has been developed for bone regeneration applications. This sponge can be easily processed into various shapes and sizes, supporting cell attachment, proliferation, and osteogenic differentiation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Ahmed Salama
Summary: Researchers are increasingly focusing on the development of unique materials from sustainable and renewable resources, with chitosan and its derivatives being versatile candidates for preparing attractive materials. Various preparation strategies for chitosan/calcium phosphate composites have been discussed and are widely applied in the biomedical and environmental fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
L. Thoraval, E. Thiebault, R. Siboni, A. Moniot, C. Guillaume, A. Jacobs, J. -M. Nedelec, G. Renaudin, S. Descamps, O. Valfort, S. C. Gangloff, J. Braux, D. Marchat, F. Velard
Summary: This study investigates the osteoimmunomodulatory properties of copper(II) ions-doped biphasic calcium phosphate (BCP) through in vitro and in vivo experiments. The results show that copper(II) ions-doped BCP promotes an inflammatory response and enhances the recruitment of polymorphonuclear neutrophils (PMNs), which may contribute to bacterial clearance and provide new insights for prosthesis coating or bone reconstruction using calcium phosphate-based biomaterials.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Yanyan Zhou, Zihe Hu, Wenjing Jin, Haiyan Wu, Minghao Zuo, Changyu Shao, Yanhua Lan, Yang Shi, Ruikang Tang, Zhuo Chen, Zhijian Xie, Jue Shi
Summary: Inspired by bionic mineralization theory, researchers have developed an organic-inorganic composite scaffold with orderly arranged hydroxyapatite nanorods along collagen fibrils. This scaffold can promote intrafibrillar mineralization and regulate the immune microenvironment simultaneously. To enhance bone regeneration, a scaffold containing ultra-small particle size calcium phosphate nanocluster (UsCCP) is prepared, which promotes both mineralization and M2-type polarization of macrophages for an immune microenvironment with osteogenic and angiogenic potential.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ho-Kyung Lim, Ik-Jae Kwon, Sung-Woon On, Seok-Jin Hong, Byoung-Eun Yang, Soung-Min Kim, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study investigated the bone regeneration capacity of BCP powder, BCP block, and BCP collagen with different concentrations of rhBMP-2 in an animal model. Results showed that increasing rhBMP-2 concentration did not significantly enhance osteogenesis, while collagen-added material may help mediate rapid bone formation in initial stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geochemistry & Geophysics
Geysivana K. Carvalho, Jose R. S. Farias, Idglan S. Lima, Ariane M. Nascimento, Gelmires A. Neves, Romualdo Menezes, Josy A. Osajima, Aluska Braga, Edson C. Silva-Filho
Summary: This study synthesized calcium phosphates using the Pechini method and analyzed their antibacterial properties. The samples were characterized, confirming the formation of biphasic ceramics of hydroxyapatite. The bacteriological test showed satisfactory results with more than 25% inhibition in bacterial growth.
Article
Immunology
Liam J. O'Neil, Christopher B. Oliveira, Donavon Sandoval-Heglund, Ana Barrera-Vargas, Javier Merayo-Chalico, Eduardo Aguirre-Aguilar, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Anti-CarP antibodies are linked to poor prognosis and bone erosion in rheumatoid arthritis (RA). Neutrophils in RA release modified autoantigens via NETs, including carbamylated LL37. Elevated levels of carbamylated LL37 were found in RA patients' plasma and synovial fluid, and could lead to autoantibody responses and bone damage in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Ceramics
Teliang Lu, Yali Miao, Xinyuan Yuan, Yu Zhang, Jiandong Ye
Summary: In this study, the effects of Mg doping on the physicochemical and biological properties of BCP scaffold were systematically studied. The results showed that Mg doping improved the sintering of BCP scaffold and reduced the degradation rate at the initial soaking period, but damaged the lattice stability of BCP and increased the degradation rate at the later soaking period. BCP scaffolds with Mg doping content ≥3 mol.% could achieve long-term sustained release of Mg and promote osteogenic differentiation and angiogenic activity.
CERAMICS INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Kyung-Hyeon Yoo, Yeon Kim, Yong-Il Kim, Moon-Kyoung Bae, Seog-Young Yoon
Summary: This study found that an appropriate amount of lithium ion doping (approximately 10%) can improve the biological properties of biphasic calcium phosphate and facilitate medical applications. However, high concentrations of lithium ions exceeding 10% can lead to crystal instability, which is not conducive to the osteogenic behavior of human dental pulp stem cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Linxin Liu, Anna Zhu, Chang Shu, Yi Zeng, John S. Ji
Summary: This study found a gene-environment interaction between FOXO gene and residential greenness on mortality in the Chinese Longitudinal Healthy Longevity Survey. Participants carrying two minor alleles of FOXO3A SNPs had lower mortality risk. Contemporaneous NDVI was associated with lower mortality risk, and the protective effect of greenness was stronger for two minor allele carriers.
REJUVENATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Dae Bum Kim, Joon Sung Kim, Cheal Wung Huh, Dae Won Ma, Jeong-Seon Ji, Byung-Wook Kim, Hwang Choi
Summary: The study compared the efficiency and safety of different sedation methods for outpatient colonoscopy, finding propofol to be superior in terms of efficiency and patient satisfaction compared to midazolam bolus or titrated administration.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Green & Sustainable Science & Technology
Jianxun Yang, Shen Qu, Miaomiao Liu, Xingyu Liu, Qi Gao, Wei He, John S. Ji, Jun Bi
Summary: This study found that degraded cityscape caused by particulate matter pollution impedes human stress recovery and causes mental discomfort. Participants viewing clean cityscape photos recovered faster and better than those viewing low-visibility cityscape photos. The results suggest that the gray cityscape reduces well-being by hampering stress recovery.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Medicine, Research & Experimental
Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Jiansong Ji
Summary: This study demonstrated that overexpression of FGFR1 and its downstream AKT/mTOR and ERK signaling activation could induce lenvatinib resistance in hepatocellular carcinoma. Both in vivo and in vitro results showed that Oxysophocarpine inhibited the proliferation and induced apoptosis of FGFR1-overexpressed HCC cells, sensitizing them to lenvatinib treatment. Mechanism studies indicated that Oxysophocarpine downregulated FGFR1 expression and its downstream signaling pathways, enhancing the effectiveness of lenvatinib in FGFR1-overexpressed HCC.
Article
Clinical Neurology
Yuesong Pan, Jing Jing, Xueli Cai, Yilong Wang, Suying Wang, Xia Meng, Chunlai Zeng, Jiong Shi, Jiansong Ji, Jinxi Lin, Lingchun Lyu, Zhe Zhang, Lerong Mei, Shiping Li, Shan Li, Wanlin Zhu, Hao Li, Tiemin Wei, Yongjun Wang
Summary: The PRECISE study is a population-based prospective cohort study that aims to comprehensively evaluate atherosclerotic stenosis and plaques using advanced vascular imaging techniques, providing data for a precise evaluation of polyvascular atherosclerosis and its association with future vascular events and cognitive impairment.
STROKE AND VASCULAR NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Tae-Geun Gweon, Kang-Moon Lee, Seung-Woo Lee, Dae Bum Kim, Jeong-Seon Ji, Ji Min Lee, Woo Chul Chung, Chang-Nyol Paik, Hwang Choi
Summary: Prophylactic hemoclip application before resecting large pedunculated polyps significantly reduces the occurrence of postpolypectomy bleeding, especially immediate bleeding. Therefore, clipping may be considered as an effective preventive measure before surgery.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Jinyu Zhu, Bufu Tang, Xiuling Lv, Miaomiao Meng, Qiaoyou Weng, Nannan Zhang, Jie Li, Kai Fan, Liyun Zheng, Shiji Fang, Min Xu, Jiansong Ji
Summary: This study identified two apoptosis genes associated with overall survival in HCC patients based on RNA sequencing data, and constructed prognostic and diagnostic models, showing that the high-risk group had lower OS time and advanced HCC patients had higher risk score and worse prognosis compared to early-stage HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Bufu Tang, Jinyu Zhu, Zhongwei Zhao, Chenying Lu, Siyu Liu, Shiji Fang, Liyun Zheng, Nannan Zhang, Minjiang Chen, Min Xu, Risheng Yu, Jiansong Ji
Summary: In this study, TMB-specific genes with good prognostic value were identified to establish diagnostic and prognostic models for HCC patients. Patients with high prognostic risk showed poorer survival probability and higher infiltration of immune cells, drug resistance, and cell proliferation and migration. These findings provide guidance for treatment strategies and improving outcomes in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Environmental Sciences
Yao Yao, Linxin Liu, Guang Guo, Yi Zeng, John S. Ji
Summary: The study found a gene-environment interaction of SIRT1 and air pollution on mortality in older Chinese adults, with the SIRT1_391 genotype showing a more significant impact among women.
ENVIRONMENTAL HEALTH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunli Kong, Zhongwei Zhao, Weiyue Chen, Xiuling Lv, Gaofeng Shu, Miaoqing Ye, Jingjing Song, Xihui Ying, Qiaoyou Weng, Wei Weng, Shiji Fang, Minjiang Chen, Jianfei Tu, Jiansong Ji
Summary: The radiomics and clinical indicator-based predictive nomogram can accurately predict tumor response in intermediate-advanced hepatocellular carcinoma patients, and may be used as an auxiliary tool for clinical prognosis assessment.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jitao Wang, Zhiyun Hou, Jianxin Liu, Ye Gu, Yunhong Wu, Zhenhuai Chen, Jiansong Ji, Shiqi Diao, Yuanwang Qiu, Shengqiang Zou, Aiguo Zhang, Nina Zhang, Fengxian Wang, Xue Li, Yan Wang, Xing Liu, Cheng Lv, Shubo Chen, Dengxiang Liu, Xiaolin Ji, Chao Liu, Tao Ren, Jingwei Sun, Zhongwei Zhao, Fazong Wu, Fenxiang Li, Ruixu Wang, Yan Yan, Shiliang Zhang, Guohong Ge, Jiangbo Shao, Shiying Yang, Chuan Liu, Yifei Huang, Dan Xu, Xiaoguo Li, Jingwen Ai, Qing He, Ming-Hua Zheng, Liting Zhang, Qing Xie, Don C. Rockey, Jonathan A. Fallowfield, Wenhong Zhang, Xiaolong Qi
Summary: The study demonstrates that COVID-19 vaccination is safe and immunogenic in patients with non-alcoholic fatty liver disease (NAFLD). Most adverse reactions post-vaccination are mild and transient.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Zhichen Jin, Li Chen, Binyan Zhong, Haifeng Zhou, Haidong Zhou, Hai Zhou, Jingjing Song, Jinhe Guo, Xiaoli Zhu, Jiansong Ji, Caifang Ni, Gaojun Teng
Summary: This study introduces a model that combines clinical radiological predictors and CT-based radiomics signature to offer preoperative individualized prediction of EVIT in patients with HCC, showing improved discrimination performance compared to clinicoradiological model.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yumin Hu, Qiaoyou Weng, Haihong Xia, Tao Chen, Chunli Kong, Weiyue Chen, Peipei Pang, Min Xu, Chenying Lu, Jiansong Ji
Summary: A radiomic nomogram based on CT arterial phase was developed and validated to differentiate primary and secondary ovarian cancers. The nomogram combining radiomic and clinical features showed good discrimination and accuracy in the training cohort, suggesting its potential clinical usefulness in this context.
ABDOMINAL RADIOLOGY
(2021)
Article
Oncology
Minjiang Chen, Feng Zhang, Jingjing Song, Qiaoyou Weng, Peicheng Li, Qiang Li, Kun Qian, Hongxiu Ji, Sean Pietrini, Jiansong Ji, Xiaoming Yang
Summary: The study demonstrates that peri-tumoral RFH combined with chemotherapy injection can enhance tumor margin destruction, potentially addressing the critical clinical issue of frequent marginal tumor recurrence/persistence following thermal ablation of large hepatic cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Yuebin Lv, Yuan Wei, Jinhui Zhou, Kai Xue, Yanbo Guo, Yang Liu, Aipeng Ju, Bing Wu, Feng Zhao, Chen Chen, Jiahui Xiong, Chengcheng Li, Heng Gu, Zhaojin Cao, John S. Ji, Xiaoming Shi
Summary: The study investigated the concentrations of toxic metals and essential metals in longevity among elderly individuals of different age groups. Men had higher concentrations of toxic metals and lower concentrations of essential metals compared to women, which may impact their lifespan. LASSO regression and random forest models identified significant metals associated with various diseases.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
