Article
Biochemistry & Molecular Biology
Pouria Hajmomeni, Sajjad Sisakhtnezhad, Ali Bidmeshkipour
Summary: Breast cancer, the most prevalent cancer in females, can be affected by mesenchymal stem cells (MSCs) and their paracrine effects. Thymoquinone (TQ) has various properties and affects the self-renewal and immunomodulatory properties of MSCs. The study examined the effect of TQ-treated MSC conditioned medium on the characteristics of breast cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Veterinary Sciences
Hyerin Suh, Suhyun Kim, Taeho Oh, Seulgi Bae
Summary: The application of canine stem cell conditioned media on canine tympanic membranes can accelerate the rate of epithelial migration, which is important for maintaining healthy ears.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Ali Shadmanesh, Hassan Nazari, Abolfazl Shirazi, Ebrahim Ahmadi, Naser Shams-Esfandabadi
Summary: This study showed that replacing serum with human amniotic membrane stem cells' conditioned medium (hAMSCs-CM) had a positive effect on blastocyst production during in vitro culture of bovine embryos, particularly in the 5% CM group.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Immunology
Yasuhiro Katahira, Fumihiro Murakami, Shinya Inoue, Satomi Miyakawa, Eri Sakamoto, Yuma Furusaka, Aruma Watanabe, Ami Sekine, Masahiko Kuroda, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto
Summary: Pressure ulcers (PUs) are a growing problem worldwide, especially with the aging population, but there are no effective treatments available. This study investigated the therapeutic potential of conditioned medium (CM) derived from immortalized stem cells (SHED) on PU formation induced by ischemia-reperfusion injury. The results showed that CM from SHEDs promoted angiogenesis and increased oxidative stress resistance, leading to therapeutic effects on PU formation. Further research is needed to meet regulatory requirements and ensure the safety and effectiveness of CM-based therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Chan Mi Lee, Yoon Young Go, Jae-Jun Song
Summary: This study demonstrates the anti-inflammatory effect of conditioned medium and extracellular vesicles derived from human trophoblast cells in treating otitis media. The underlying mechanism of cell migration during inflammatory healing was identified through RNA-sequencing analysis. This research holds significant clinical potential for treating chronic inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Wataru Katagiri, Satoshi Endo, Ryoko Takeuchi, Daisuke Suda, Naoaki Saito, Tadaharu Kobayashi
Summary: This study found that injecting MSC-CM can improve condylar resorption, enhance gene expression related to osteogenesis, chondrogenesis, and angiogenesis, and slow down the progression of CR in a rat model.
Article
Dermatology
Seon Bok Lee, Hyun-Tae Shin, Ji Won Byun, Jeonghyun Shin, Gwang Seong Choi
Summary: The study demonstrated that ASC-CM combined with 10,600 nm carbon dioxide fractional laser or microneedling may offer effective and safe treatment options for a refractory patch of alopecia areata.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Biology
Benson Koh, Farynna Hana Ab Rahman, Najwa Amira Matlan, Manissha Rajan, Aimi Yasmin Musta'ain, Mohamad Ridhwan Mohd Jeffry Lee, Roszalina Ramli, Siti Salmiah Mohd Yunus, Ruszymah Binti Hj Idrus, Muhammad Dain Yazid
Summary: DPSCs conditioned medium has the potential to induce odontoblastic differentiation in WJMSCs, but further research is needed to understand its stimulating effects and signaling pathways.
BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Filip Humenik, Marcela Maloveska, Nikola Hudakova, Patricia Petrouskova, Zuzana Sufliarska, L'ubica Hornakova, Alexandra Valencakova, Martin Kozar, Barbora Siskova, Dagmar Mudronova, Martin Bartkovsky, Dasa Cizkova
Summary: The aim of this study was to investigate the beneficial treatment effect of canine amniotic membrane-derived mesenchymal stem cell products (AM-MSC) on complicated wound healing in dogs. Characterization of AM-MSCs showed their distinctive features and potential for differentiation. In vitro studies demonstrated a significant decrease in scratch area on skin fibroblast cultures treated with canine amniotic mesenchymal stem cell conditioned media (AMMSC-CM). In the experimental study, the combination therapy of antibiotics, NSAIDs, and local AMMSC-CM application resulted in a substantial reduction in wound surface area compared to conventional therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Anatomy & Morphology
A. Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Archana A. Gupta, Shankargouda Patil
Summary: This study assessed the effect of human MSC derived conditioned media on human cancer cell lines, identifying pro-carcinogenic and anti-carcinogenic molecules and effector pathways associated with different MSC types. The use of MSC-CM with pro-carcinogenic effect should be restricted in cancer patients regardless of the application nature.
Article
Anatomy & Morphology
T. B. Sivanarayanan, Irfan Ahmad Bhat, Khan Sharun, Sangeetha Palakkara, Rashmi Singh, V Remya, Mehtab Singh Parmar, Rahul Bhardwaj, Vikash Chandra, Palanivelu Munuswamy, Prakash Kinjavdekar, A. M. Pawde, Amarpal Amarpal, G. Taru Sharma
Summary: The study evaluated the healing potential of BM-MSCs and BM-MSCs-CM in acute and subacute injuries in a rabbit peripheral nerve injury model. Results showed that both BM-MSCs and BM-MSCs-CM enhanced the regenerative capacity, with slightly better improvement in the subacute injury group. It can be concluded that BM-MSCs support the healing of injured peripheral nerves, and BM-MSCs-CM accelerates the healing of acute and subacute peripheral nerve injuries in rabbits.
Article
Medicine, Research & Experimental
N. A. Bondarenko, M. A. Surovtseva, I. I. Kim, A. P. Lykov, I. A. Iskakov, A. N. Trunov, V. V. Chernykh, O. V. Poveshchenko
Summary: This study investigated the effects of conditioned media from different cell types on the functional activity of human limbal mesenchymal stem cells. The results showed that conditioned media from limbal epithelial stem cells inhibited the proliferation and migration of the stem cells, and led to changes in protein concentrations. However, conditioned media from corneal stromal cells had no effect on the functional activity of the stem cells. These findings contribute to our understanding of the interactions between limbal and corneal cells, which are crucial for maintaining corneal homeostasis.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeong
Summary: The study assessed the neuroregenerative effects of stem cell-conditioned medium in a Parkinson's disease-related cell model, and found that this treatment method had significant protective effects against cell toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Daphne Pinheiro, Isabelle Dias, Thiago Freire, Alessandra Alves Thole, Ana Carolina Stumbo, Erika Afonso Costa Cortez, Lais de Carvalho, Simone Nunes de Carvalho
Summary: The study demonstrated that MSC CM treatment reduced hepatic enzyme levels and collagen deposition in the liver, while also decreasing the profibrotic IL-17A and increasing IL-6 and IL-4. This suggests that MSC CM treatment has therapeutic potential in cholestatic liver fibrosis, promoting matrix remodeling and cytokine profile favorable for liver regeneration.
Article
Biochemistry & Molecular Biology
Yoon-Young Go, Chan-Mi Lee, Sung-Won Chae, Jae-Jun Song
Summary: The study demonstrated the potential of trophoblast-derived conditioned medium (TB-CM) in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and inhibiting adipogenesis. By activating biological processes such as signaling pathways, the trophoblast-derived secretomes show promise for clinical interventions in bone regeneration and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Ashraf A. Aly, Alaa A. Hassan, Maysa M. Makhlouf, Mohammed B. Alshammari, Sara Mohamed Naguib Abdel Hafez, Marwa M. M. Refaie, Stefan Braese, Martin Nieger, Mohamed Ramadan
Summary: The newly synthesized hydrazinocarbothioamides with a phenylsulfonyl group showed promising antihyperglycemic activity in streptozotocin-induced diabetic mice, significantly reducing blood glucose levels and improving oxidative stress conditions.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Soha Abdelkawy Abdelwahab, Sara Abdel Gawad Elsebay, Manar Fouli Gaber Ibrahim, Sara Mohamed Naguib Abdel Hafez
Summary: The study focuses on the impact of Parkinson's disease on the cerebral cortex and cerebellum for better understanding and treatment. The use of stem cell-conditioned medium shows promise in alleviating the effects of Parkinson's disease in both brain regions.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Medicine, Research & Experimental
Sara Mohamed Naguib Abdel Hafez, Eman Elbassuoni, Walaa Yehia Abdelzaher, Nermeen N. Welson, Gaber El-Saber Batiha, Khalid J. Alzahrani, Fatma Alzhraa Fouad Abdelbaky
Summary: The study revealed that methotrexate caused various placental morphological changes, but vitamin E played a protective role in attenuating the placental toxicity, restoring the placental weight and oxidant/antioxidant balance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Heba A. Abdel-Hamid
Summary: The study found that PRP treatment can improve diabetes-induced cardiac changes, including reducing oxidative stress, inflammation, and cardiac injury, as well as decreasing the number of macrophages, collagen fiber area, and immune-positive cardiac muscle.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Sara Mohamed Naguib Abdel Hafez, Eman Elbassuoni
Summary: Intermittent fasting has protective effects on the aged liver in rats, reducing inflammation and cell death while regulating autophagy. This suggests that intermittent fasting could serve as a simple, safe, and inexpensive therapeutic intervention for age-related liver changes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hany Ezzat Khalil, Miada F. Abdelwahab, Promise Madu Emeka, Lorina I. Badger-Emeka, Krishnaraj Thirugnanasambantham, Hairul-Islam Mohamed Ibrahim, Sara Mohamed Naguib, Katsuyoshi Matsunami, Nada M. Abdel-Wahab
Summary: This study demonstrates Ocimum forskolei and hesperidin as potential candidates for treating diabetes mellitus by regulating blood glucose and lipid levels, and having protective and antiapoptotic effects.
Article
Biochemistry & Molecular Biology
Sara M. Mostafa, Ashraf A. Aly, Stefan Brase, Martin Nieger, Sara Mohamed Naguib Abdelhafez, Walaa Yehia Abdelzaher, El-Shimaa M. N. Abdelhafez
Summary: This study synthesized and tested a series of novel thiadiazole analogues as antiapoptotic agents and investigated their protective effects against renal ischemia/reperfusion. The results showed that these compounds exhibited good antiapoptotic activity, with compounds 2c and 2g showing the most significant antiapoptotic effects and biomarkers.
Article
Chemistry, Multidisciplinary
Hany Ezzat Khalil, Miada F. Abdelwahab, Promise Madu Emeka, Lorina Badger-Emeka, Sara Mohamed Naguib Abdel Hafez, Khalid A. AlYahya, Al-Shaimaa F. Ahmed, Aliaa F. Anter, Nada M. Abdel-Wahab, Katsuyoshi Matsunami, Alyaa Hatem Ibrahim Selim
Summary: In this study, the preventive effect of broccoli leaf by-product extract (BL) on gentamicin-induced renal and hepatic injury was investigated. The results showed that BL could reduce the impact of gentamicin on biochemical parameters and protect the liver and kidneys by reducing tissue damage.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Medicinal
Walaa Yehia Abdelzaher, Gomaa Mostafa-Hedeab, Haitham Ahmed Bahaa, Ahmad Mahran, Michael Atef Fawzy, Sara Mohamed Naguib Abdel Hafez, Nermeen N. Welson, Remon Roshdy Rofaeil
Summary: The study investigated the potential protective role of montelukast in a pre-eclampsia rat model. Montelukast improved oxidative stress, inflammation, and liver and kidney damage caused by L-NG-Nitro arginine methyl ester (L-NAME). It also restored the normal architecture of the placenta, liver, and kidney tissues. The findings suggest that montelukast may have therapeutic potential for pre-eclampsia.
Article
Pharmacology & Pharmacy
Asmaa I. Matouk, Mahmoud El-Daly, Heba A. Habib, Shaymaa Senousy, Sara Mohamed Naguib Abdel Hafez, AlShaimaa W. Kasem, Waleed Hassan Almalki, Abdulaziz Alzahrani, Ahmed Alshehri, Al-Shaimaa F. Ahmed
Summary: This study suggests that menthol has therapeutic potential against liver injury induced by sepsis. It reduces elevated liver enzymes and improves histopathological changes in the liver. It also decreases inflammation and oxidative stress levels and increases the levels of anti-apoptotic factors and biomarkers of regeneration and survival in the liver.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed A. Morsy, Yasmine F. Ibrahim, Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Seham A. Abdel-Gaber
Summary: Paeonol can protect against hepatic ischemia/reperfusion injury by inhibiting oxidative stress, inflammation, and apoptosis.
Article
Chemistry, Medicinal
Mohamed A. Morsy, Rania Abdel-Latif, Sara Mohamed Naguib Abdel Hafez, Mahmoud Kandeel, Seham A. Abdel-Gaber
Summary: The study found that paeonol has a protective effect against MTX-induced hepatotoxicity. This protection is achieved by suppressing oxidative stress, inflammation, fibrosis, and apoptosis pathways, and enhancing cell proliferation and survival through upregulation of P-gp and Mrp-2.
Article
Biology
Hany Ezzat Khalil, Miada F. Abdelwahab, Promise Madu Emeka, Lorina Badger-Emeka, Al-Shaimaa F. Ahmed, Aliaa E. Anter, Sara Mohamed Naguib Abdel Hafez, Khalid A. AlYahya, Hairul-Islam Mohamed Ibrahim, Krishnaraj Thirugnanasambantham, Katsuyoshi Matsunami, Alyaa Hatem Ibrahim Selim
Summary: This study found that cauliflower leaf extract can improve gentamicin-induced renal and hepatic injuries and reduce oxidative stress. The waste-to-wealth potential of cauliflower is worth further exploration.
Article
Pharmacology & Pharmacy
Sara Mohamed Naguib Abdel Hafez, Entesar Ali Saber, Neven Makram Aziz, Maha Yehia Kamel, Ashraf A. Aly, El-Shimaa M. N. Abdelhafez, Manar Fouli Gaber Ibrahim
Summary: 3,3'-Methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) has protective effects against Blemomycin-induced lung injury by exerting anti-oxidative, anti-inflammatory, and anti-apoptotic effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Heba A. Shawky, Sara Mohamed Naguib Abdel Hafez, Nabil Abdel Kader Hasan, Eman Elbassuoni, Fatma Alzhraa Fouad Abdelbaky, Abdel Hamid Sayed Abobakr
Summary: This study evaluated the effects of inverted light-dark cycle on the histological changes in the adrenal cortex and pineal gland in adult male albino rats. The findings showed that inverted light-dark cycle resulted in biochemical and histological alterations in the adrenal cortex and pineal gland. This provides valuable insights into the importance of sleep quality.
MICROSCOPY AND MICROANALYSIS
(2023)
