The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction

MicroRNA expression profile analysis in sperm reveals hsa-mir-191 as an auspicious omen of in vitro fertilization

(2020) Hua Xu et al.   BMC GENOMICS

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

(2020) Jennifer C. Chan et al.   Nature Communications

Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions

(2019) Wei Zhou et al.   BMC BIOLOGY

Profiling of epididymal small non‐protein‐coding RNA s

(2019) B. Nixon et al.   Andrology

Orchestrating the antioxidant defenses in the epididymis

(2019) C. O'Flaherty   Andrology

Caput Epididymidal Mouse Sperm Support Full Development

(2019) Dongjie Zhou et al.   DEVELOPMENTAL CELL

The contribution of epididymosomes to the sperm small RNA profile

(2019) Natalie A Trigg et al.   REPRODUCTION

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Control of noncoding RNA production and histone levels by a 5′ tRNA fragment

(2019) Ana Boskovic et al.   GENES & DEVELOPMENT

Alteration of transporter activities in the epididymides of infertile initial segment-specific Pten knockout mice†

(2018) Bingfang Xu et al.   BIOLOGY OF REPRODUCTION

Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function

(2018) Estela J. Jauregui et al.   DEVELOPMENT

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

(2018) David A. Dickson et al.   Translational Psychiatry

Sperm epigenetics and influence of environmental factors

(2018) Ida Donkin et al.   Molecular Metabolism

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice

(2018) Colin C. Conine et al.   DEVELOPMENTAL CELL

Proteomic profiling of mouse epididymosomes reveals their contributions to post-testicular sperm maturation

(2018) Brett Nixon et al.   MOLECULAR & CELLULAR PROTEOMICS

Contractility of the epididymal duct - function, regulation and potential drug effects

(2018) Vera Elfgen et al.   REPRODUCTION

Paternal Exercise Improves Glucose Metabolism in Adult Offspring

(2018) Kristin I. Stanford et al.   DIABETES

Expression of tamoxifen-inducible CRE recombinase in Lcn5-CreERT2 transgenic mouse caput epididymis

(2017) Juan Xu et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Molecular changes and signaling events occurring in spermatozoa during epididymal maturation

(2017) M. G. Gervasi et al.   Andrology

What is a placental mammal anyway?

(2017) Patrick Abbot et al.   eLife

Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

(2017) A K Short et al.   Translational Psychiatry

Gametogenesis from Pluripotent Stem Cells

(2016) Mitinori Saitou et al.   Cell Stem Cell

The human epididymis: its function in sperm maturation

(2016) Robert Sullivan et al.   HUMAN REPRODUCTION UPDATE

Spermatogenesis: The Commitment to Meiosis

(2016) Michael D. Griswold   PHYSIOLOGICAL REVIEWS

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

(2016) A K Short et al.   Translational Psychiatry

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome

(2016) Jackson N. Reilly et al.   Scientific Reports

Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring

(2015) Nicole O. McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Extracellular microRNAs from the epididymis as potential mediators of cell-to-cell communication

(2015) Clémence Belleannée   ASIAN JOURNAL OF ANDROLOGY

Epididymosomes: a heterogeneous population of microvesicles with multiple functions in sperm maturation and storage

(2015) Robert Sullivan   ASIAN JOURNAL OF ANDROLOGY

Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience

(2015) Ali B. Rodgers et al.   BIOLOGICAL PSYCHIATRY

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Regulators of Ovarian Preantral Follicle Development

(2015) Renju Raj et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Epididymal Binder of SPerm genes and proteins: what do we know a decade later?

(2015) G. Plante et al.   Andrology

mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice

(2015) S. Yuan et al.   Biology Open

Sperm Proteome Maturation in the Mouse Epididymis

(2015) Sheri Skerget et al.   PLoS One

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Influences of Maternal and Paternal PTSD on Epigenetic Regulation of the Glucocorticoid Receptor Gene in Holocaust Survivor Offspring

(2014) Rachel Yehuda et al.   AMERICAN JOURNAL OF PSYCHIATRY

MicroRNA-34c Expression in Donor Cells Influences the Early Development of Somatic Cell Nuclear Transfer Bovine Embryos

(2014) Bo Wang et al.   Cellular Reprogramming

Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis1

(2013) Clémence Belleannée et al.   BIOLOGY OF REPRODUCTION

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3

(2013) J. A. Maldera et al.   MOLECULAR HUMAN REPRODUCTION

CD9-Positive Microvesicles Mediate the Transfer of Molecules to Bovine Spermatozoa during Epididymal Maturation

(2013) Julieta N. Caballero et al.   PLoS One

Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology

(2013) Robert Sullivan et al.   REPRODUCTION

MIR-34c regulates mouse embryonic stem cells differentiation into male germ-like cells through RARg

(2012) Shanshan Zhang et al.   CELL BIOCHEMISTRY AND FUNCTION

Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

(2012) T. Fullston et al.   HUMAN REPRODUCTION

Epididymosome-Mediated Acquisition of MMSDH, an Androgen-Dependent and Developmentally Regulated Epididymal Sperm Protein

(2012) A. R. Suryawanshi et al.   JOURNAL OF ANDROLOGY

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

Comparative proteome and lipid profiles of bovine epididymosomes collected in the intraluminal compartment of the caput and cauda epididymidis

(2011) J. Girouard et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Epididymal Protein CRISP1 Plays Different Roles During the Fertilization Process

(2011) D. J. Cohen et al.   JOURNAL OF ANDROLOGY

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

New insights into epididymal biology and function

(2009) G. A. Cornwall   HUMAN REPRODUCTION UPDATE

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane

(2009) Jeong Su Oh et al.   MOLECULES AND CELLS