The Potential Contribution of Dysfunctional RNA-Binding Proteins to the Pathogenesis of Neurodegeneration in Multiple Sclerosis and Relevant Models

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

(2020) Josiah J. Herzog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-binding protein altered expression and mislocalization in MS

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Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR

(2020) Cristiana Pistono et al.   Multiple Sclerosis and Related Disorders

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Mitchell T Wallin et al.   LANCET NEUROLOGY

TDP-43 proteinopathy in Theiler’s murine encephalomyelitis virus infection

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Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis

(2019) Sangmin Lee et al.   PLoS One

Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases?

(2019) Peter Hoch-Kraft et al.   NEUROCHEMICAL RESEARCH

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS

(2019) Desiree M Baron et al.   HUMAN MOLECULAR GENETICS

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls

(2019) Tone Berge et al.   Clinical Proteomics

Integrating stress responses and immunity

(2019) Philippe Pierre   SCIENCE

A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis

(2019) Elzbieta Dorota Miller et al.   Nutrients

Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy

(2019) Yuan Boyao et al.   JOURNAL OF NEUROIMMUNOLOGY

Dysfunctional RNA‐binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice

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Properties of Stress Granule and P-Body Proteomes

(2019) Ji-Young Youn et al.   MOLECULAR CELL

Stress granules and neurodegeneration

(2019) Benjamin Wolozin et al.   NATURE REVIEWS NEUROSCIENCE

Antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1 contribute to neuronal cell loss in an animal model of multiple sclerosis

(2019) Cole D. Libner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

(2019) Amit Bar-Or et al.   TRENDS IN MOLECULAR MEDICINE

Involvement of Mitochondria in Neurodegeneration in Multiple Sclerosis

(2018) M. S. Kozin et al.   BIOCHEMISTRY-MOSCOW

Oxidative stress and neurodegeneration: the involvement of iron

(2018) Alessia Carocci et al.   BIOMETALS

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Linking hnRNP Function to ALS and FTD Pathology

(2018) Maria D. Purice et al.   Frontiers in Neuroscience

Chronic starvation induces non-canonical pro-death stress granules

(2018) Lucas C. Reineke et al.   JOURNAL OF CELL SCIENCE

Dysfunctional RNA binding proteins and stress granules in multiple sclerosis

(2018) Hannah E. Salapa et al.   JOURNAL OF NEUROIMMUNOLOGY

Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function

(2018) Eva-Maria Hock et al.   Cell Reports

cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

(2018) Haitao Wang et al.   Frontiers in Molecular Neuroscience

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

(2018) Ryan J. Bevan et al.   ANNALS OF NEUROLOGY

Differences between acute and chronic stress granules, and how these differences may impact function in human disease

(2018) Lucas C. Reineke et al.   BIOCHEMICAL PHARMACOLOGY

Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination

(2018) Jia Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide triggers the assembly of “type II” stress granules linked to decreased cell viability

(2018) Anaïs Aulas et al.   Cell Death & Disease

Autoantibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNPA1) cause altered ‘ribostasis’ and neurodegeneration; the legacy of HAM/TSP as a model of progressive multiple sclerosis

(2017) Michael C. Levin et al.   JOURNAL OF NEUROIMMUNOLOGY

RNA Binding Protein Human Antigen R Is Translocated in Astrocytes following Spinal Cord Injury and Promotes the Inflammatory Response

(2017) Thaddaeus Kwan et al.   JOURNAL OF NEUROTRAUMA

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

(2017) StevenM LeVine et al.   Neural Regeneration Research

Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis

(2017) Maria Domenica Sanna et al.   NEUROPHARMACOLOGY

PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions

(2017) Giuliana Catara et al.   Scientific Reports

TDP-43 misexpression causes defects in dendritic growth

(2017) Josiah J. Herzog et al.   Scientific Reports

The Multiple Sclerosis (MS) Genetic Risk Factors Indicate both Acquired and Innate Immune Cell Subsets Contribute to MS Pathogenesis and Identify Novel Therapeutic Opportunities

(2017) Grant P. Parnell et al.   Frontiers in Immunology

Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

(2017) Timur Khaibullin et al.   Frontiers in Immunology

Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development

(2016) Bruna Soares Landeira et al.   CEREBRAL CORTEX

CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review

(2016) Kavitha Kothur et al.   CYTOKINE

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease

(2016) Joshua N. Douglas et al.   Journal of Neuroinflammation

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Antibodies in multiple sclerosis oligoclonal bands target debris

(2016) Ryan C. Winger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

(2016) Aarti Sharma et al.   Nature Communications

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

(2016) Benedetta Bolognesi et al.   Cell Reports

Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Omega-3 Fatty Acids for Depression in Multiple Sclerosis: A Randomized Pilot Study

(2016) Lynne Shinto et al.   PLoS One

Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells

(2015) So Jung Park et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The immunogenetics of multiple sclerosis: A comprehensive review

(2015) Jill A. Hollenbach et al.   JOURNAL OF AUTOIMMUNITY

Th Cell Diversity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2015) Kevin S. Carbajal et al.   JOURNAL OF IMMUNOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

(2015) Jeffery D Haines et al.   NATURE NEUROSCIENCE

TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

(2015) J. P. Ling et al.   SCIENCE

Inflammation Induces TDP-43 Mislocalization and Aggregation

(2015) Ana Sofia Correia et al.   PLoS One

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS

(2014) Erik Ellwardt et al.   EXPERIMENTAL NEUROLOGY

Developing a Therapeutic Plan for Treating MS

(2014) Michael C. Levin et al.   JOURNAL OF CLINICAL PSYCHIATRY

mRNP granules

(2014) J Ross Buchan   RNA Biology

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma

(2013) Eva Bentmann et al.   FEBS Journal

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

(2013) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

(2013) E. S. Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomised, double-blind, placebo-controlled proof-of-concept clinical trial

(2013) Marios C Pantzaris et al.   BMJ Open

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

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Neurodegeneration in multiple sclerosis: novel treatment strategies

(2012) Felix Luessi et al.   Expert Review of Neurotherapeutics

Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)

(2012) Eva Bentmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies

(2012) T. Vanderweyde et al.   JOURNAL OF NEUROSCIENCE

Regulated protein aggregation: stress granules and neurodegeneration

(2012) Benjamin Wolozin   Molecular Neurodegeneration

Vitamin D as a protective factor in multiple sclerosis

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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

(2011) Lionel M. Igaz et al.   JOURNAL OF CLINICAL INVESTIGATION

A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease

(2011) Sangmin Lee et al.   JOURNAL OF NEUROIMMUNOLOGY

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(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

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A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

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Inflammation, demyelination, and degeneration — Recent insights from MS pathology

(2010) Christine Stadelmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

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Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

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(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

TDP-43 is recruited to stress granules in conditions of oxidative insult

(2009) Claudia Colombrita et al.   JOURNAL OF NEUROCHEMISTRY

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

MRI measures show significant cerebellar gray matter volume loss in multiple sclerosis and are associated with cerebellar dysfunction

(2009) VM Anderson et al.   Multiple Sclerosis Journal

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(2008) Michael A. Gitcho et al.   Alzheimers & Dementia

Gray matter atrophy is related to long-term disability in multiple sclerosis

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Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

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