Article
Clinical Neurology
Michael Wainberg, Shea J. Andrews, Shreejoy J. Tripathy
Summary: In this study, using state-of-the-art GWAS techniques, researchers identified shared genetic risk loci among Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. These loci revealed the importance of lysosomal/autophagic dysfunction, neuroinflammation/immunity, oxidative stress, and the DNA damage response in the pathogenesis of multiple neurodegenerative disorders.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Genetics & Heredity
Veria Vacchiano, Anna Bartoletti-Stella, Giovanni Rizzo, Patrizia Avoni, Piero Parchi, Fabrizio Salvi, Rocco Liguori, Sabina Capellari
Summary: ALS and AD patients have a higher prevalence of Lewy body disease and parkinsonian features. This study found a higher frequency of Parkinson's disease-causative genes in ALS patients, suggesting their potential role in ALS pathogenesis.
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Antonio Martin-Bastida, Robert R. Crichton
Summary: This review explores the iron deposition in the brains of PD patients, the role of neuroinflammation and glia cells, and the potential therapeutic effects of iron chelators. The combination of anti-inflammatory drugs with iron chelators is proposed as a better approach to enhance chelator efficacy in treating PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia-Petre Costin, Luca-Andrei Glavan, Antonio-Daniel Corlatescu, Vicentiu Mircea Saceleanu
Summary: Neurodegenerative diseases are a leading cause of disability and death worldwide. Recent advancements in technology and understanding, as well as the potential of gene editing, have fueled exponential growth in the field of molecular genetics. This paper aims to analyze the latest approaches in genetics and molecular sciences for four major neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. By focusing on treatment, diagnosis, and predictions, the goal is to improve analysis and identify emerging signs for better outcomes and potential novel therapies targeting specific genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anamaria Jurcau
Summary: With an aging population, the incidence of neurodegenerative diseases is on the rise, and current treatments primarily focus on symptom relief. Preventative measures such as a healthy lifestyle and avoidance of oxidative stress are recommended.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Hongkun Di, Yi Zhu, Wenqi Xia, Xin Meng, Mingye Zhang, Minzhi Xu, Jing Feng, Qingfeng Tian, Yan He, Shiyi Cao, Zuxun Lu
Summary: This study examines the bidirectional causal relationships between sleep traits, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) using Mendelian randomization analysis. The results suggest that there is no causal association between sleep disorders and PD, but PD risk may causally influence ALS risk.
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Ryan W. Dellinger, Jose M. Estrela
Summary: ALS is a degenerative disease with no cure or proven therapy. While some drugs have been approved for treatment, there has been no significant breakthrough in the field.
Article
Geriatrics & Gerontology
Barbara Poletti, Federica Solca, Sabrina Maffi, Silvia Torre, Laura Carelli, Edoardo Nicolo Aiello, Roberta Ferrucci, Alberto Priori, Alessia Monti, Federico Verde, Nicola Ticozzi, Simone Migliore, Eugenia Scaricamazza, Melissa Casella, Ferdinando Squitieri, Andrea Ciammola, Vincenzo Silani
Summary: This study provides unprecedented insights into the heterogeneous semiology and determinants of apathy across ALS, PD, and HD via the Dimensional Apathy Scale (DAS), in turn informing clinical practice and research.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Douglas P. Wightman, Jeanne E. Savage, Elleke Tissink, Cato Romero, Iris E. Jansen, Danielle Posthuma
Summary: Neurodegenerative diseases are a group of disorders characterized by neuronal cell death, causing various physical and mental problems. This study identified genetic overlap between three or more neurodegenerative disorders, including shared genetic loci, important genes, and tissues. These findings are important for understanding and treating neurodegenerative diseases.
NEUROBIOLOGY OF AGING
(2023)
Article
Pharmacology & Pharmacy
J. S. Dileep Kumar, Andrei Molotkov, Jongho Kim, Patrick Carberry, Sidney Idumonyi, John Castrillon, Karen Duff, Neil A. Shneider, Akiva Mintz
Summary: In this study, we observed a decrease in microtubule binding of [C-11]MPC-6827 in transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. These findings suggest that [C-11]MPC-6827 could potentially serve as a PET ligand for imaging Alzheimer's disease, ALS, and other neurodegenerative diseases.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Andrea Mastrangelo, Veria Vacchiano, Corrado Zenesini, Edoardo Ruggeri, Simone Baiardi, Arianna Cherici, Patrizia Avoni, Barbara Polischi, Francesca Santoro, Sabina Capellari, Rocco Liguori, Piero Parchi
Summary: Recent studies have shown that ALS patients have higher levels of plasma GFAP compared to controls, and this marker is associated with cognitive decline. Plasma GFAP is an accurate biomarker for identifying Alzheimer's disease co-pathology in ALS, which can influence the cognitive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Constanza Moren, Ruth Mary deSouza, Darly Milena Giraldo, Christopher Uff
Summary: Neurodegenerative diseases are characterized by mitochondrial dysfunction and oxidative stress. Antioxidant therapy using polyphenols, carotenes, vitamins, and hormones such as melatonin has been widely used as adjunctive treatment for various brain pathologies. This review focuses on the mitochondrial antioxidant targets in major neurodegenerative disorders and summarizes the latest placebo-controlled trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lana Kupershmidt, Moussa B. H. Youdim
Summary: Researchers have developed multi-target, non-toxic, lipophilic, brain-permeable compounds with iron chelation and anti-apoptotic properties for the treatment of neurological disorders. These compounds have been tested in animal and cellular models and have shown neuroprotective effects by attenuating neurodegenerative pathology, promoting positive behavior changes, and up-regulating neuroprotective signaling pathways.
Review
Cell Biology
Taha Alqahtani, Sharada L. Deore, Anjali A. Kide, Bhavana A. Shende, Ritika Sharma, Rita Dadarao Chakole, Lalita S. Nemade, Nikita Kishor Kale, Sudarshana Borah, Savita Shrikant Deokar, Ashok Behera, Divya Dhawal Bhandari, Nikita Gaikwad, Abul Kalam Azad, Arabinda Ghosh
Summary: Misfolded proteins in the central nervous system can induce oxidative damage, impacting mitochondrial function and leading to neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and Amyotrophic Lateral Sclerosis. Mitochondrial dynamics play a crucial role in cellular apoptosis and are affected by these diseases. The dysfunction of mitochondria contributes to the selective neurodegeneration seen in these disorders. Novel techniques are being explored to treat mitochondrial malfunction and oxidative stress in these neurodegenerative diseases.
News Item
Biochemistry & Molecular Biology
Surya K. De
Summary: This patent describes the use of novel pyrroloppyrimidine compounds as LRRK2 kinase inhibitors for the treatment or prevention of diseases associated with LRRK2 kinase activity, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS).
CURRENT MEDICINAL CHEMISTRY
(2023)