Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR

Progression of the role of CRYAB in signaling pathways and cancers

(2019) Junfei Zhang et al.   OncoTargets and Therapy

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

(2019) João D. Santos et al.   Cells

Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity

(2019) Weimin Xu et al.   Mucosal Immunology

The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

(2018) Zhihui Zhu et al.   NEUROCHEMISTRY INTERNATIONAL

Inflammation in cystic fibrosis: An update

(2018) Erica A. Roesch et al.   PEDIATRIC PULMONOLOGY

Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer

(2018) Ryosuke Fukuda et al.   Frontiers in Pharmacology

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF

(2018) Paul D.W. Eckford et al.   Journal of Cystic Fibrosis

Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation

(2018) Xiaoyan Gong et al.   MOLECULAR BIOLOGY OF THE CELL

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense

(2017) Emma Svedin et al.   JOURNAL OF INFECTIOUS DISEASES

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

(2017) Miklos Bagdany et al.   Nature Communications

Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis

(2017) Gabriel Fung et al.   Oncotarget

Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators

(2017) Iwona M. Pranke et al.   Scientific Reports

Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins

(2016) Michela Ciano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis

(2016) Jérémy Rocca et al.   BRITISH JOURNAL OF PHARMACOLOGY

Correctors Rescue CFTR Mutations in Nucleotide-Binding Domain 1 (NBD1) by Modulating Proteostasis

(2016) Miquéias Lopes-Pacheco et al.   CHEMBIOCHEM

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27

(2015) Miquéias Lopes-Pacheco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR

(2015) Agata M. Trzcińska-Daneluti et al.   MOLECULAR & CELLULAR PROTEOMICS

Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial

(2015) Johannes M. van Noort et al.   PLoS One

HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

(2014) André-Patrick Arrigo et al.   Cancers

The cytosolic chaperone  -crystallin B rescues folding and compartmentalization of misfolded multispan transmembrane proteins

(2013) M. D'Agostino et al.   JOURNAL OF CELL SCIENCE

Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

(2012) Johannes M. van Noort et al.   BIOMATERIALS

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

(2012) Annette Ahner et al.   MOLECULAR BIOLOGY OF THE CELL

Protein localization in disease and therapy

(2011) M.-C. Hung et al.   JOURNAL OF CELL SCIENCE

Small Heat Shock Proteins and Protein-Misfolding Diseases

(2010) Ewa Laskowska et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

(2010) Michel J. Vos et al.   HUMAN MOLECULAR GENETICS

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

Evidence for direct CFTR inhibition by CFTRinh-172 based on Arg347mutagenesis

(2008) Emanuela Caci et al.   BIOCHEMICAL JOURNAL

Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels

(2008) Beate Illek et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY