Article
Chemistry, Applied
Qing-Qing Lv, Juan-Juan Cao, Rui Liu, Han-Qing Chen
Summary: Two polysaccharide fractions, WXA-1 and AXA-1, were isolated from wheat bran in this study. Structural analysis revealed that they are heteropolysaccharides, with AXA-1 showing stronger inhibitory effects on enzyme activities compared to WXA-1.
Article
Biochemistry & Molecular Biology
ShuangShuang Gu, HuiQing Sun, XiaoLing Zhang, FuNing Huang, LiChao Pan, ZhenYuan Zhu
Summary: The novel acidic polysaccharide AWPA was extracted from Annona squamosa residue, characterized by various analytical methods, and showed potential inhibitory activity against α-glucosidase and α-amylase.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Yanan Jia, Zihan Xue, Yajie Wang, Yangpeng Lu, Ruilin Li, Nannan Li, Qirou Wang, Min Zhang, Haixia Chen
Summary: This study aimed to explore the effect of different corn silk polysaccharide fractions obtained by ethanol precipitation on their physicochemical properties and biological activities. The results showed that the fractions exhibited differences in physical properties and activities, with CSP80 showing stronger antioxidant activity and alpha-glucosidase inhibitory activity. Enzyme kinetic analysis indicated that CSP80 inhibited alpha-glucosidase by mixed type and reversible mechanisms, and fluorescence intensity measurements confirmed changes in the secondary structure of alpha-glucosidase due to the binding of CSP80. Isothermal titration calorimetry results illustrated that the binding of CSP80 to alpha-glucosidase complex was driven by enthalpy and hydrogen bonds played a major role in the binding process.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Zhijun Xiao, Changyang Yan, Chunxue Jia, Ying Li, Yuanlin Li, Jie Li, Xinxin Yang, Xueyan Zhan, Changhua Ma
Summary: This study aims to extract and purify an active heteropolysaccharide called Chia seed polysaccharide (CSP-A), characterize its structure, and evaluate its antioxidant and immunomodulatory activities. The results showed that CSP-A had moderate antioxidant activity and immune regulation effect. This study provides scientific basis for further utilization and development of Chia seeds as a functional food.
Article
Chemistry, Applied
Nani Wang, Pingcui Xu, Weixuan Yao, Jiali Zhang, Shufen Liu, Yongjun Wang, Yan Zhang
Summary: PPCP-1, an arabinogalactan isolated from Phellodendron chinense Schneid., shows potential in protecting against diabetic osteoporosis through various mechanisms, making it a potential functional food or drug for bone health.
CARBOHYDRATE POLYMERS
(2021)
Article
Agricultural Engineering
Aneta Wojdylo, Karolina Tkacz, Paulina Nowicka, Igor Piotr Turkiewicz
Summary: This study investigated the content of various nutrients and biological activities of different cultivars of Chaenomeles leaves. The results showed that Chaenomeles leaves are rich in phenolics, free amino acids, tocopherols, tocotrienols, and possess enzyme inhibition activity. They can be used as a valuable source for extracting these compounds.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Linan Zhou, Yeling Li, Xiaotang Gong, Zhengguo Li, Honglin Wang, Lingling Ma, Muhetaer Tuerhong, Munira Abudukeremu, Yasushi Ohizumi, Jing Xu
Summary: Researchers have developed composite nanoparticles by combining natural polysaccharides with selenium, which effectively inhibited the growth of breast cancer cells and demonstrated anti-tumor effects in zebrafish assays.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Minghao Fan, Yilin Qian, Wei Yue, Yuqi Yang, Xin Zhang, Shuang Ma, Ying Xu, Dongfeng Wang
Summary: The study investigated the effects of metal elements on the activity of metal-polysaccharide complexes, showing that metallic elements may reduce the hypoglycemic activity of polysaccharides. Four Fe-tea polysaccharide complexes were prepared and three tea polysaccharides were extracted to explore their binding modes with metallic elements and inhibitory effects on alpha-glucosidase. The results revealed that the activity of Fe-TPS on alpha-glucosidase was lower than that without Fe, suggesting that metallic elements have the potential to decrease the hypoglycemic activity of TPS.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Xiaoshan Long, Xiao Hu, Shaobo Zhou, Huan Xiang, Shengjun Chen, Laihao Li, Shucheng Liu, Xianqing Yang
Summary: Gracilaria lemaneiformis polysaccharide (GLP) was degraded by hydrogen peroxide combined with vitamin C (H2O2-Vc) to produce a new product called GLP-HV. The chemical characteristics and in vitro activities of GLP-HV and its degradation products were assessed.
Article
Chemistry, Applied
Jongbin Lim, Mario G. Ferruzzi, Bruce R. Hamaker
Summary: This study identified the structural requirements for selectively inhibiting human alpha-amylase versus alpha-glucosidase using flavonoids, revealing the critical role of double bonds and hydroxyl groups in different positions. Through selective inhibition of the two classes of starch digestive enzymes, flavonoids can effectively control digestion rate to improve physiological responses.
Article
Chemistry, Applied
Mandeep Kaur, Raj Kaushal
Summary: The synthesized vanadyl chalcone complexes showed moderate to significant inhibition activity against antidiabetic enzymes and demonstrated remarkable antioxidant activity. This suggests promising potential for both antidiabetic and antioxidant applications.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Di Zhang, Xuhao Liu, Zhikun Yang, Jiyong Shi, Lei Zhao, Maurizio Battino, Jianbo Xiao, Xinyue Deng, Yanling Wu, Chengtao Wang, Bolin Shi, Xiaobo Zou
Summary: The study identified the key components in 26 varieties of Zanthoxylum pericarps responsible for inhibiting in vitro alpha-glucosidase. Using techniques like principal component analysis and ingredient recombination models, the researchers confirmed the antagonistic effect of phenols and hydroxy-alpha-sanshool in this inhibition process. Spectrophotometric assays, NMR, and MD were utilized to characterize the interactions among these components, shedding light on the structural mechanism behind their antagonistic behavior.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Qian Yu, Wei Chen, Jing Zhong, Dong Huang, Wenting Shi, Haiyun Chen, Chunyan Yan
Summary: Coreopsis tinctoria Nutt. is widely cultivated in western regions of China. A water-soluble polysaccharide (CT70-1) was isolated from C. tinctoria, which showed inhibitory activity against α-amylase, α-glucosidase, and nitric oxide production. These findings provide a foundation for the potential use of CT70-1 in the food and pharmaceutical industries.
Article
Biochemistry & Molecular Biology
Xiaohong Lu, Mengya Wang, Zhezhen Zhao, Jinrong Hu, Jingsheng Zhang, Ping Liu
Summary: This study demonstrated that alkali treatment of birch sawdust was the most effective method in promoting the production of active polysaccharides by Inonotus obliquus. Through structural characterization and analysis, it was shown that alkali treatment destroyed the lignin structure of birch sawdust and exposed the cellulose for better utilization.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sajedeh Safapoor, Mohammad Halimi, Minoo Khalili Ghomi, Milad Noori, Navid Dastyafteh, Shahrzad Javanshir, Samanesadat Hosseini, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Ensieh Nasli-Esfahani, Bagher Larijani, Azadeh Fakhrioliaei, Mohammad G. Dekamin, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi
Summary: A new series of quinoline-quinazolinone-thioacetamide derivatives 9a-p were designed and synthesized. These compounds showed significant anti-a-glucosidase activity, with compound 9g being the most potent inhibitor. Molecular simulation studies revealed that compound 9g occupied the active site of a-glucosidase with favorable binding energy. In silico ADMET studies of the most potent compounds predicted their drug-likeness, pharmacokinetic, and toxicity properties.
Article
Food Science & Technology
Yejun Deng, Lixin Huang, Caihong Zhang, Pujun Xie
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Chemistry, Multidisciplinary
Jiang Cheng, Lujie Liu, Lixin Huang, Caihong Zhang, Pujun Xie, Yejun Deng, Kehua Tang
Review
Chemistry, Applied
Xiang Wang, Lixin Huang, Caihong Zhang, Yejun Deng, Pujun Xie, Lujie Liu, Jiang Cheng
CARBOHYDRATE POLYMERS
(2020)
Article
Agricultural Engineering
Yejun Deng, Lixin Huang, Caihong Zhang, Pujun Xie, Jiang Cheng, Xiang Wang, Lujie Liu
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Biochemistry & Molecular Biology
Pujun Xie, Linlin Fan, Lixin Huang, Caihong Zhang
Summary: Hydroxytyrosol oligomerization catalyzed by laccase performed best at 50 degrees C for 20 minutes in an aqueous buffer solution with a pH of 5.0. Molecular docking revealed interactions between multiple amino acid residues and hydroxytyrosol, while molecular dynamic results confirmed structural changes in the enzymes. Structural analysis showed significant changes in torsion and bond lengths.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Agricultural Engineering
Pujun Xie, Linlin Fan, Lixin Huang, Caihong Zhang
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Chemistry, Applied
Pujun Xie, Linlin Fan, Lixin Huang, Caihong Zhang
Summary: The hydroxytyrosol oligomer prepared by bioenzyme exhibits stronger health-promoting properties compared to its monomer. However, the polymerization process carried out by laccase, tyrosinase or horseradish peroxidase lacks sufficient product characterization, kinetics and thermodynamics. Further investigations using ATR-FT-IR, NMR, Michaelis-Menten equation and isothermal titration calorimetry revealed that the identified polymers had a C-C bond and a degree of polymerization less than six. The polymerization processes were found to be spontaneous and exothermic behaviors driven by hydrogen bonds, van der Waals interactions and hydrophobic interactions. Circular dichroism spectroscopy showed significant enzymatic structural changes during the catalysis, with beta-sheet levels for laccase, alpha-helix levels for tyrosinase, and a decrease in alpha-helix and random coil levels for horseradish peroxidase.
Article
Food Science & Technology
Pujun Xie, Lorenzo Cecchi, Maria Bellumori, Diletta Balli, Lisa Giovannelli, Lixin Huang, Nadia Mulinacci
Summary: Phenolic and triterpenoid compounds from olive trees have multiple protective effects on human health and exhibit cytotoxicity on colorectal cancer cells. Different parts of the olive tree, including leaves, branches, fruits, pomace, shells, seeds, and olive oil, contain varying amounts of these bioactive compounds, with specific compounds showing significant inhibitory effects on cell proliferation.
Article
Chemistry, Applied
Zhiwen Qi, Xingying Xue, Hao Zhou, Hua Yuan, Wenjun Li, Guliang Yang, Pujun Xie, Chengzhang Wang
Summary: The study demonstrated that OPs-AgNPs can serve as excellent antimicrobial agents, exhibiting significant antibacterial capabilities against E. coli, primarily through disrupting the cell wall and regulating Ca2+-ATPase activity.
Article
Agronomy
Zhiwen Qi, Xingying Xue, Xuefeng Xu, Hao Zhou, Wenjun Li, Guliang Yang, Pujun Xie
Summary: This study aimed to prepare detoxified and antimicrobial-enhanced OPs capping ZnO nanoparticles, which showed improved stability and antimicrobial activity, and prolonged the shelf-life of fresh produce during storage.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)