Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94

Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model

(2016) Dhivya R. Sudhan et al.   INTERNATIONAL JOURNAL OF CANCER

Cathepsin L targeting in cancer treatment

(2015) Dhivya R. Sudhan et al.   PHARMACOLOGY & THERAPEUTICS

Modulation of the tumor vasculature and oxygenation to improve therapy

(2015) Dietmar W. Siemann et al.   PHARMACOLOGY & THERAPEUTICS

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cysteine Cathepsin Activity Regulation by Glycosaminoglycans

(2014) Marko Novinec et al.   Biomed Research International

Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells

(2013) Dhivya R. Sudhan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Plasma Cathepsin L and Its Related Pro/Antiangiogenic Factors Play Useful Roles in Predicting Rich Coronary Collaterals in Patients with Coronary Heart Disease

(2013) J Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

(2012) Gustavo E. Chavarria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cathepsin L Activity Is Essential to Elastase Perfusion–Induced Abdominal Aortic Aneurysms in Mice

(2011) Jiusong Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

(2011) Ji Hyung Chung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Epigenetic regulation of cathepsin L expression in chronic myeloid leukaemia

(2011) Misti Samaiya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers

(2010) Misti Jain et al.   ANNALS OF HEMATOLOGY

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

(2010) J. Montojo et al.   BIOINFORMATICS

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L

(2010) G.D. Kishore Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents

(2010) Dietmar W. Siemann   CANCER TREATMENT REVIEWS

Dynamics of endothelial cell behavior in sprouting angiogenesis

(2010) Hanna M Eilken et al.   CURRENT OPINION IN CELL BIOLOGY

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract

(2010) Irina Arnaoutova et al.   Nature Protocols

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

(2009) Silvia Jordans et al.   BMC BIOCHEMISTRY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

(2009) R. E. Burden et al.   CLINICAL CANCER RESEARCH

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

(2009) J Dennemärker et al.   ONCOGENE

Intratumoral gene delivery of anti-cathepsin L single-chain variable fragment by lentiviral vector inhibits tumor progression induced by human melanoma cells

(2008) R Frade et al.   CANCER GENE THERAPY

Role of Urinary Cathepsin B and L in the Detection of Bladder Urothelial Cell Carcinoma

(2008) Robert S. Svatek et al.   JOURNAL OF UROLOGY

Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead

(2007) V. W.M. van Hinsbergh et al.   CARDIOVASCULAR RESEARCH