Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells

Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607

(2012) Yao Dai et al.   BMC CANCER

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

(2012) Gustavo E. Chavarria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

(2011) Ji Hyung Chung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Impact of Hypoxia on the Metastatic Potential of Human Prostate Cancer Cells

(2011) Yao Dai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration

(2010) Yolanda M. Fortenberry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cathepsin L in metastatic bone disease: therapeutic implications

(2010) Gaetano Leto et al.   BIOLOGICAL CHEMISTRY

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

(2010) G.D. Kishore Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?

(2009) Ann F. Chambers   CANCER RESEARCH

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors

(2009) Eva Kolwijck et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

Na+/H+Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Lysosome Trafficking in Prostate Cancer Cells

(2009) Joshua J. Steffan et al.   TRAFFIC

The tumor microenvironment and metastatic disease

(2008) Sarah Jane Lunt et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY