Article
Medicine, Research & Experimental
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: This study proposes a novel therapeutic approach for SjS by blocking MHC class II I-Ag-7 antigen presentation in NOD mice. The results demonstrate that treating NOD mice with TATD or 8-Azaguanine can alleviate SjS symptoms and reduce the severity of the disease.
Article
Biochemistry & Molecular Biology
Ankur Saikia, Andries Hadeler, Pranathi Prasad, Martin Zacharias, Sebastian Springer
Summary: This study investigates the importance of peptide exchange in immunodominance and uncovers the mechanism of peptide exchange under low pH conditions. The results demonstrate that low pH triggers peptide exchange and provide insights into the individual steps of the exchange reaction.
Review
Immunology
Andy van Hateren, Tim Elliott
Summary: The selection of peptides presented by MHC-I molecules plays a crucial role in immune responses. The proteins tapasin and TAPBPR coordinate the peptide selection process, ensuring that MHC-I molecules acquire high-affinity-binding peptides. New structural analyses have provided insights into the mechanisms of tapasin's role within the peptide-loading complex and TAPBPR's ability to independently perform peptide editing. These structures reveal the intricate interactions between tapasin, TAPBPR, and MHC-I, as well as the complementary roles of calreticulin and ERp57 in achieving peptide editing.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ewa Maria Sroka, Mathilde Lavigne, Marika Pla, Chrysoula Daskalogianni, Maria Camila Tovar-Fernandez, Rodrigo Prado Martins, Benedicte Manoury, Guillaume Darrasse-Jeze, Megane Nascimento, Sebastien Apcher, Robin Fahraeus
Summary: This study found that introducing an MHC class I epitope sequence into the intron of the beta-globin gene in mice can generate immune tolerance. Translation initiation within the intron produces peptides for MHC class I immune tolerance, providing an explanation for the tolerance of alternative tissue-specific splicing by the immune system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Elena Shklovskaya, Helen Rizos
Summary: It is well acknowledged that the immune system plays a role in controlling tumor growth, but tumors can escape immune surveillance through mechanisms like downregulation or loss of MHC-I molecules. This review examines the dysregulation of MHC-I expression in cancer, the nature of MHC-I-bound antigenic peptides, and discusses therapeutic strategies to address MHC-I deficiency in solid tumors with a focus on NK cells and CD4 T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Fuxu Wang, Haoyan Wang, Lizhuang Wang, Haoyu Lu, Shizheng Qiu, Tianyi Zang, Xinjun Zhang, Yang Hu
Summary: This study introduces the MHCRoBERTa method, which uses RoBERTa pre-training approach to predict the binding affinity between type I MHC and peptides. Experimental results show that MHCRoBERTa outperforms other prediction methods, with a significant improvement on IC50 value, demonstrating its potential in cancer immunotherapy.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Neurosciences
Ana Laura M. R. Tomiyama, Luciana Politti Cartarozzi, Liliande Oliveira Coser, Gabriela Bortolanca Chiarotto, Alexandre L. R. Oliveira
Summary: This study investigated the influence of IFN beta treatment on ALS mice. The results showed that low dosage of IFN beta increased the expression of MHC-I, leading to neuroprotection and immunomodulation during the presymptomatic phase of ALS. The treatment also affected synaptic preservation and microglia activation. Additionally, IFN beta treatment decreased the expression of the anti-inflammatory cytokine IL4.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Richel J. C. Bilderbeek, Maksim V. Baranov, Geert van den Bogaart, Frans Bianchi
Summary: This study reveals the over-presentation of membrane protein fragments in cytolytic and helper T cell responses. It also demonstrates the evolutionary conservation and lower frequency of mutations in transmembrane helices, suggesting that T cells are more tuned to respond to membrane proteins to avoid evasion by pathogens.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Edyta Wieczorek, Malgorzata A. Garstka
Summary: This study focuses on the relationship between MHC class I and BC, discussing the importance and application of MHC class I in BC treatment. The paper suggests that loss of MHC class I expression in BC may affect treatment outcomes, and explores methods to enhance MHC class I antigen presentation to CD8+ T cells, emphasizing the significance of immune status in predicting treatment outcomes for BC patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemical Research Methods
Max Hoek, Laura C. Demmers, Wei Wu, Albert J. R. Heck
Summary: The study analyzed in depth the N-glycosylation features of HLA class I molecules, finding that HLA-A alpha-chains have distinct glycosylation patterns compared to HLA-B, HLA-C, and HLA-F. The cellular distribution of HLA molecules varies based on their glycosylation features, with HLA-B predominantly found at the plasma membrane, and HLA-C and HLA-F mainly located in the endoplasmic reticulum and Golgi membrane. The findings highlight the importance of considering allotype-specific cellular distribution when analyzing peptide antigen presentation in immunopeptidomics.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Patricia T. Illing, Andy van Hateren, Rachel Darley, Nathan P. Croft, Nicole A. Mifsud, Samuel King, Lyudmila Kostenko, Mandvi Bharadwaj, James McCluskey, Tim Elliott, Anthony W. Purcell
Summary: Abacavir hypersensitivity syndrome occurs in individuals with a specific gene expression, altering immune responses. Research shows that abacavir affects the assembly of HLA-B*57:01 complexes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Benjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. M. Shao, Dipika Singh, Kellie N. N. Smith, Valsamo Anagnostou, Rachel Karchin
Summary: Researchers propose a method based on long short-term memory ensembles and transfer learning to predict effective neoepitopes that elicit an immune response. This method can help address the challenge of predicting immunogenicity of neoepitopes in developing personalized cancer vaccines. Compared to other state-of-the-art classifiers, this method significantly improves the prediction of epitope presentation.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Immunology
Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Michael C. Young, Julia N. Danon, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis
Summary: Major Histocompatibility Complex class I (MHC-I) molecules present self, viral or aberrant epitopic peptides to T cell receptors (TCRs) through interactions with complementarity-determining regions and MHC-I heavy chain 'framework' residues. In this study, using structural data from peptide:MHC-I and pMHC:TCR structures, the researchers identified important residues for peptide and/or TCR binding and proposed a fixed-backbone computational design approach for engineering synthetic molecules with desired properties. Experimental results showed that chimeric molecules bridging divergent HLA alleles can bind selected peptide antigens, highlighting the potential of these synthetic HLA molecules as screening probes for peptide-centric interactions with TCRs and other therapeutic modalities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Anastasia Thoma, Kate E. Earl, Katarzyna Goljanek-Whysall, Adam P. Lightfoot
Summary: MHC I overexpression may play an important role in the development of autoimmune diseases such as myositis, possibly through the activation of the ER stress pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Piotr Minias, Scott V. Edwards, Wieslaw Babik
Summary: By analyzing MHC gene sequences in birds, two ancient MHC-IIA gene lineages were discovered and found to be closely associated with the distribution of MHC-IIB gene lineages. The study also suggests that specific pairing of MHC-II alpha and beta chains may have adaptive significance in evolution.
FRONTIERS IN IMMUNOLOGY
(2023)
