4.7 Article

Association of Hypertension and Blood Pressure With Kidney Cancer Risk A Nationwide Population-Based Cohort Study

期刊

HYPERTENSION
卷 75, 期 6, 页码 1439-1446

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.120.14820

关键词

blood pressure; body weight; cardiology; hypertension; incidence

资金

  1. National Research Foundation (NRF) of Korea - Ministry of Science and ICT (MSIT) [NRF-2017M3A9E8023001, NRF-2017M3A9E8023018]
  2. NRF of Korea - Ministry of Education [NRF-2018R1D1A1B07042999]
  3. Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI18C0331]
  4. Chonnam National University Hospital Institute for Biomedical Science [BCRI19030]
  5. National Research Foundation of Korea [2017M3A9E8023018] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Data regarding health behavior-related factors and systolic or diastolic blood pressure to evaluate the association between blood pressure and kidney cancer are lacking. Using nationally representative data from the Korean National Health Insurance System, 9 746 445 participants without kidney cancer between January 1, 2006 and December 31, 2009 were followed up until December 31, 2017 to obtain data regarding cancer incidence. Participants were categorized, according to blood pressure, as normal (<120/80 mm Hg), elevated (120-129/<80 mm Hg), and hypertensive (>= 130/80 mm Hg) with or without antihypertensive medication, according to the 2017 American College of Cardiology and American Heart Association blood pressure guidelines. Kidney cancer was noted in 11 083 participants during the 8-year follow-up. Participants with hypertension were at higher risk for kidney cancer than those without hypertension. Participants with hypertension using medication had a higher cancer risk than those not using medication and those with elevated blood pressure. The risk of kidney cancer significantly increased with higher systolic or diastolic blood pressure, in a dose-dependent manner, even after adjusting for antihypertensive medication use. Therefore, hypertension and high systolic or diastolic blood pressure, compared with normal blood pressure, were associated with an increased risk of kidney cancer.

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