Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD

(2021) Dong-Hyun Kim et al.   Cell Death & Disease

Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage

(2021) Shifeng Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis

(2021) Sophia M. Sears et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice

(2021) Yasumasa Ikeda et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury

(2021) Yi Wang et al.   BIOCHEMICAL PHARMACOLOGY

Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis

(2020) Qingmiao Lu et al.   Cell Death & Disease

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis

(2019) Dong-Hyun Kim et al.   FASEB JOURNAL

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

(2019) Fei Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

(2019) Eikan Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A powerful cell-protection system prevents cell death by ferroptosis

(2019) Brent R. Stockwell   NATURE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

(2017) Xiaoxin X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small Maf proteins (MafF, MafG, MafK): History, structure and function

(2016) Fumiki Katsuoka et al.   GENE

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice

(2015) Zhibo Gai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by ActivatingSOD3

(2015) Yan-Dong Wang et al.   MOLECULAR ENDOCRINOLOGY

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

Farnesoid X Receptor Ligand Prevents Cisplatin-Induced Kidney Injury by Enhancing Small Heterodimer Partner

(2014) Eun Hui Bae et al.   PLoS One

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells

(2012) Cheng Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor

(2009) Masahiro Nomoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY