An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in Acute Myeloid Leukemia

Methylation of Wnt antagonist genes: a useful prognostic marker for myelodysplastic syndrome

(2012) Hong Wang et al.   ANNALS OF HEMATOLOGY

High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

(2012) K. H. Metzeler et al.   BLOOD

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes

(2012) P. A. Greif et al.   HAEMATOLOGICA

RUNX1Mutations Are Associated With Poor Outcome in Younger and Older Patients With Cytogenetically Normal Acute Myeloid Leukemia and With Distinct Gene and MicroRNA Expression Signatures

(2012) Jason H. Mendler et al.   JOURNAL OF CLINICAL ONCOLOGY

Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia

(2011) H-A Hou et al.   BRITISH JOURNAL OF CANCER

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value

(2011) M. Pratcorona et al.   HAEMATOLOGICA

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

(2011) T C Luis et al.   LEUKEMIA

Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas

(2011) Yasushi Matsuyama et al.   MOLECULAR CARCINOGENESIS

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation

(2010) Elizabeth A. Griffiths et al.   LEUKEMIA & LYMPHOMA

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

(2009) M. E. Figueroa et al.   BLOOD

Analysis of AML genes in dysregulated molecular networks

(2009) Eunjung Lee et al.   BMC BIOINFORMATICS

Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia

(2009) Vanesa Martín et al.   CANCER SCIENCE

Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia

(2009) A Valencia et al.   LEUKEMIA

Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation

(2008) T. C. Luis et al.   BLOOD

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

(2008) E. Colado et al.   HAEMATOLOGICA