Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition

(2020) Morgan Oatley et al.   Nature Communications

Developmental trajectory of pre-hematopoietic stem cell formation from endothelium

(2020) Qin Zhu et al.   BLOOD

Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses

(2020) Siyuan Hou et al.   CELL RESEARCH

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

(2019) Qilin Gu et al.   SCIENCE

Risk variants disrupting enhancers of TH1 and TREG cells in type 1 diabetes

(2019) Peng Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors

(2019) Jane Gilmour et al.   Epigenetics & Chromatin

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

(2019) Changya Chen et al.   Cell Reports

RUNX1 and the endothelial origin of blood

(2018) Long Gao et al.   EXPERIMENTAL HEMATOLOGY

Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in hPSC cultures

(2018) Igor I. Slukvin et al.   EXPERIMENTAL HEMATOLOGY

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1

(2017) Joanna Tober et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny

(2017) Miguel Ganuza et al.   NATURE CELL BIOLOGY

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

(2016) Biola M. Javierre et al.   CELL

Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver

(2016) Stanislav Rybtsov et al.   DEVELOPMENT

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

(2016) Debbie K. Goode et al.   DEVELOPMENTAL CELL

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition

(2016) Özge Vargel et al.   Scientific Reports

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

(2016) Mauricio Cortes et al.   Cell Reports

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

(2015) Javed K. Manesia et al.   Stem Cell Research

Oceans of opportunity: Exploring vertebrate hematopoiesis in zebrafish

(2014) Kelli J. Carroll et al.   EXPERIMENTAL HEMATOLOGY

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells

(2014) Annouck Luyten et al.   GENES & DEVELOPMENT

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

(2014) S. Vanhee et al.   HAEMATOLOGICA

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Global view of enhancer-promoter interactome in human cells

(2014) B. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence

(2014) Chunxia Zhang et al.   Nature Communications

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

(2012) C. Lancrin et al.   BLOOD

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

(2012) Kim-Chew Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

(2011) J. A. I. Thoms et al.   BLOOD

Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

(2011) Andrejs Ivanovs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discover regulatory DNA elements using chromatin signatures and artificial neural network

(2010) Hiram A. Firpi et al.   BIOINFORMATICS

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

(2010) T. Yokomizo et al.   DEVELOPMENT

GATA2 and Sp1 Positively Regulate the c-kit Promoter in Mast Cells

(2010) K. Maeda et al.   JOURNAL OF IMMUNOLOGY

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters

(2009) T. Bee et al.   BLOOD

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb

(2008) J. Tober et al.   BLOOD

AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain

(2008) Hui Wei et al.   FEBS LETTERS