Article
Oncology
Wen-Kai Shi, Qiao-Li Shang, Yong-Fu Zhao
Summary: This study investigates the role of SPC25 in promoting hepatocellular carcinoma (HCC) progression. It is found that SPC25 is highly expressed in HCC and associated with poor prognosis and metastasis. Silencing SPC25 inhibits invasion and migration of HCC cells in vitro and in vivo. The study also reveals that SPC25 affects genes associated with extracellular matrix-integrin interactions, and upregulation of ITGB4 partially reverses the decline in cell invasion and migration capacities caused by SPC25 silencing. Blocking both SPC25 and ITGB4 reduces phosphorylation of downstream elements in the integrin pathway. Overall, this research highlights the important role of SPC25 as both a prognostic indicator and a promoter of metastasis in HCC.
Article
Immunology
Chun-Han Hou, Chih-Hsin Tang, Po-Chun Chen, Ju-Fang Liu
Summary: The study demonstrated that Thrombospondin-2 could promote the expression of IL-6 in osteoarthritis synovial fibroblasts in a dose-dependent manner, potentially involving signaling pathways such as integrin alpha(v)beta(3), PI3K, Akt, and NF-kappa B. Additionally, in a rat model of ACLT surgery, it was found that TSP2 neutralizing antibody had protective effects on cartilage destruction during OA progression.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Huijuan Liu, Honglian Tao, Hongqi Wang, Yuyan Yang, Ru Yang, Xintong Dai, Xiujuan Ding, Haidong Wu, Shuang Chen, Tao Sun
Summary: The study revealed that PAR1 promotes CSC-like properties and EMT in pancreatic cancer cells, while Doxycycline inhibits pancreatic cancer growth by suppressing the PAR1/FAK/PI3K/AKT pathway and enhances the therapeutic effect of 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yonghe Li, Yaolin Yin, Yi He, Kun He, Jingdong Li
Summary: This study investigated the influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells. High expression of SOS1 was observed in most human liver cancers, indicating a worse prognosis. Knockout of SOS1 significantly decreased cell invasion and migration, inhibited the epithelial-mesenchymal transition (EMT), and suppressed the PI3K/AKT/mTOR pathway. These findings suggest that SOS1 may play a role in promoting invasion, migration, and metastasis of HCC cells through the activation of the PI3K/AKT/mTOR pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Article
Pharmacology & Pharmacy
Jiang Li, Qian Wei, Ke Song, Youxin Wang, Yuxin Yang, Miao Li, Jiaying Yu, Guangxu Su, Luyuan Peng, Bendong Fu, Pengfei Yi
Summary: This study investigated the role and potential mechanisms of Tangeretin (Tan) in pulmonary fibrosis. The results demonstrated that Tan can suppress inflammation, oxidative stress, and epithelial-mesenchymal transition (EMT) in bleomycin-induced pulmonary fibrosis via the PI3K/Akt pathway, suggesting its potential as a treatment for pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Chien-Liang Liu, Yi-Chiung Hsu, Chi-Yu Kuo, Jie-Yang Jhuang, Ying-Syuan Li, Shih-Ping Cheng
Summary: CRABP2 expression is upregulated in thyroid cancer and associated with adverse prognosis. CRABP2 expression is related to the invasion capacity of thyroid cancer cells and may promote invasion through the integrin/focal adhesion kinase/AKT pathway.
Article
Medicine, General & Internal
Lu Huang, Qiong Yang, Huihong Chen, Zhenggeng Wang, Qi Liu, Shuhua Ai
Summary: In hepatocellular carcinoma, Tollip overexpression promotes tumor progression by enhancing proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of cancer cells, through the activation of the PI3K/AKT signaling pathway. Blocking the Tollip-PI3K/AKT axis may offer a potential therapeutic strategy for hepatocellular carcinoma management.
Article
Biology
Xiao Yang, Wangjie Jiang, Xiangxu Kong, Xiao Zhou, Deming Zhu, Lianbao Kong
Summary: Genistein can upregulate miR-1275 expression and inhibit the epithelial mesenchymal transformation (EMT) and stemness of hepatocellular carcinoma (HCC). MiR-1275 inhibits EMT and stemness of HCC by suppressing the EIF5A2/PI3K/Akt pathway.
Article
Plant Sciences
Zhihua Liu, Zhengxu Zhang, Xiaonan Chen, Ping Ma, Ying Peng, Xiaobo Li
Summary: This study investigated the protective effects and underlying mechanisms of citrate and hydroxycinnamate derivatives in Mume Fructus on intestinal epithelial injury. Network pharmacology analysis predicted multiple targets and pathways associated with Crohn's disease, and cell validation experiments confirmed the ability of these derivatives to promote cell proliferation and inhibit damage caused by lipopolysaccharide. Activation of the FAK/PI3K/AKT signaling pathway was identified as a potential mechanism for the protective effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingjing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Summary: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in bone defect regeneration. Resistin, an adipose tissue-specific secretory factor, has diverse functions including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on BMSCs' osteogenic differentiation are still unclear.
Article
Food Science & Technology
Xiang Gao, Yuhuan Jiang, Qi Xu, Feng Liu, Xuening Pang, Mingji Wang, Qun Li, Zichao Li
Summary: The natural flavonoid compound 4-hydroxyderricin (4-HD) derived from Angelica keiskei shows significant inhibitory effects on hepatocellular carcinoma (HCC) cells, by promoting apoptosis and cell cycle arrest through the PI3K/AKT/mTOR signaling pathway.
Review
Medicine, Research & Experimental
Ju Huang, Congcong Wang, Yixuan Hou, Yuanyuan Tian, Yanru Li, Haiying Zhang, Lihong Zhang, Wei Li
Summary: This review discusses the differences between vasculogenic mimicry (VM) and the classical tumor angiogenesis model, as well as the impact of VM on prognosis and survival rates in patients with highly aggressive cancer. The review also highlights the limitations of traditional anti-tumor angiogenesis therapy and the important role of thrombospondin 2 (THBS2) in angiogenesis. Furthermore, the review explores the mechanisms by which THBS2 participates in and regulates tumor VM through the activation of the PI3K/AKT/mTOR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Xiangyuan Luo, Mengdie Cao, Fan Gao, Xingxing He
Summary: YTHDF1 is overexpressed in HCC and associated with HCC grade. It promotes the growth of HCC cells by activating the PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition (EMT) to enhance migration and invasion.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Engineering, Environmental
Qiuxia Han, Sifan Ai, Quan Hong, Chuyue Zhang, Yanqi Song, Xiaochen Wang, Xu Wang, Shaoyuan Cui, Zongjin Li, Hanyu Zhu, Zhimou Yang, Xiangmei Chen, Guangyan Cai
Summary: A novel Biotin-(D)FYIGSRGD hydrogel was developed by conjugating YIGSR and RGD peptides, which prolonged the survival of MSCs and enhanced their anti-apoptotic and anti-inflammatory effects on kidney injury.
CHEMICAL ENGINEERING JOURNAL
(2022)
