Article
Multidisciplinary Sciences
Akimitsu Kugimiya, Sho Wakimoto, Jiro Kohda, Yasuhisa Nakano, Yu Takano
Summary: A one-step analysis method using a microfluidic paper-based analytical device was developed for detecting four types of amino acids. The method is simple, easy, and allows for simultaneous detection of multiple amino acid concentrations.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Chunying Feng, Kohei Takahashi, Jianan Zhu
Summary: A method has been developed to selectively pattern the surface wettability of PDMS microfluidic devices for the generation of double emulsion (DE) droplets. The method utilizes plasma treatment to increase the hydrophilicity of PDMS, enabling the production of both water-in-oil-in-water and oil-in-water-in-oil DE droplets. The resulting microfluidic devices can be used for a variety of applications involving DE droplets.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
JuYeon Kim, Hyeongjin Lee, Eun-Ju Jin, Yunju Jo, Baeki E. Kang, Dongryeol Ryu, GeunHyung Kim
Summary: By using a microfluidic device with cell-laden methacrylated gelatin (GelMa) bioink and alginate as matrix hydrogel, a functional hybrid structure laden with cell-aggregated microbeads is fabricated to enhance cell-to-cell interactions. This approach improves cellular activities and myogenesis in comparison to conventional bioprinted structures, demonstrating a promising method for tissue engineering applications.
Article
Computer Science, Information Systems
Xun Wang, Ke Sun, Ting Zhao, Wei Wang, Qing Gu
Summary: In this paper, a Dynamic Speed Warping (DSW) algorithm is proposed for one-shot learning of device-free acoustic gesture signals performed by different users. The design of DSW is based on the observation that gesture type is determined by the trajectory of hand components rather than the movement speed. By dynamically scaling the speed distribution and tracking the movement distance along the trajectory, DSW can effectively match gesture signals from different domains with a ten-fold difference in speeds. Experimental results show that DSW can achieve a recognition accuracy of 97% for gestures performed by unknown users while only using one training sample of each gesture type from four training users.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2023)
Article
Chemistry, Analytical
Xiaojun Li, Ziyi He, Chong Li, Peng Li
Summary: The one-step assay using a 3D-printed microfluidic device simplifies enzyme kinetics measurement by eliminating the preparation and handling of multiple solutions. With a highly efficient vibrating mixing method, experiments with different substrate concentrations can be performed by adjusting flow rates, yielding consistent Michaelis constant values. This method offers advantages such as simplicity in fabrication and operation, rapid analysis, low power consumption, and high temporal resolution.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Chunyang Wei, Chengzhuang Yu, Shanshan Li, Tiejun Li, Jiyu Meng, Junwei Li
Summary: The presented microfluidic chip provides a possible solution for achieving 3D cell culture and enabling scalable and high-throughput cell culture, with great potential for application in biological fields.
Article
Biochemical Research Methods
Mahsa Jalali, Imman Isaac Hosseini, Tamer AbdelFatah, Laura Montermini, Sebastian Wachsmann Hogiu, Janusz Rak, Sara Mahshid
Summary: EVs shed by cancer cells can provide valuable diagnostic information, but clinical use of liquid biopsy based on EVs is hindered by inefficient testing methods. A nanostructured microfluidic device utilizing SERS has been developed for unambiguous identification of EVs from different tumor cell populations, showing promising potential for broader applications in cancer research.
Article
Chemistry, Analytical
Chawin Srisomwat, Abdulhadee Yakoh, Natthaya Chuaypen, Pisit Tangkijvanich, Tirayut Vilaivan, Orawon Chailapakul
Summary: An automated paper-based eLFA device was developed for quantitative detection of hepatitis B virus (HBV) using a time-delayed microfluidic strategy and gold metallization for signal-on electrochemical detection of target DNA. The use of pyrrolidinyl peptide nucleic acid as a probe provided higher specificity and lower background currents, achieving a broad dynamic range and excellent detection limit. The device simplifies the operation for HBV DNA detection without the need for amplification steps, while producing results consistent with standard real-time PCR.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Ali Reza Bahari, Mobin Abdar Esfahani, Mojtaba Taghipoor
Summary: Transparent electrowetting is a branch of EWOD devices that use transparent electrodes for optical applications. This paper introduces a transparent EWOD with permanent liquid electrodes. Liquid electrodes were used instead of conventional solid-state ones. The concept of Liquid Electrode EWOD (LEWOD) is successfully implemented on both rigid and flexible substrates. Results show promising performance similar to PCBs, indicating potential future applications of liquid electrodes in EWOD systems.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Nanoscience & Nanotechnology
Tomas Pinheiro, Ana C. Marques, Patricia Carvalho, Rodrigo Martins, Elvira Fortunato
Summary: The article presents a signal transduction method based on gold nanoparticles for the development of paper-based multiplex colorimetric assay devices for diabetes control, showing the potential for multiparametric colorimetric measurement.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Analytical
Karuna Chandnani, Niraj Rajput, Tarang Jadav, Megha Pillai, Pooja Dhakne, Rakesh K. Tekade, Pinaki Sengupta
Summary: This review discusses the advancements in microfluidic chip-based devices for biomarker quantification, including sample preparation techniques, chip-integrated systems, and bio-materials. It also explores the potential of microfluidic devices in overcoming traditional limitations and their impact on biomarker analysis.
MICROCHEMICAL JOURNAL
(2023)
Article
Biophysics
Jaewoo Lim, Byunghoon Kang, Hye Young Son, Byeonggeol Mun, Yong-Min Huh, Hyun Wook Rho, Taejoon Kang, Jeong Moon, Jae-Jong Lee, Seung Beom Seo, Soojin Jang, Seong Uk Son, Juyeon Jung, Seungjoo Haam, Eun-Kyung Lim
Summary: The newly developed exoNA-sensing chip, based on microfluidic and 3D-nanostructured hydrogels, allows for rapid detection of ERBB2 with high accuracy and selectivity.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Physical
Mihaela Puiu, Valentin Mirceski, Camelia Bala
Summary: Paper-based analytical devices have become essential components in point-of-care applications, especially when used in conjunction with microfluidic platforms. Paper-based electrochemical devices (PEDs) are preferred for lab-on-a-chip biosensors due to their simplicity, affordability, portability, and disposability. Despite their low costs and simplicity, PEDs face the challenge of meeting various criteria to be affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable to end users.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Biochemical Research Methods
Thomas Michael Shiju, Chaturvedula Tripura, Pritam Saha, Arushi Mansingh, Venkatapathi Challa, Ira Bhatnagar, Narayana Nagesh, Amit Asthana
Summary: Paper-based nucleic acid detection and diagnosis is a promising approach for point-of-care applications. This study demonstrates the successful synthesis of cDNA on cellulose-based paper devices at room temperature, providing a simple and time-saving method for nucleic acid amplification testing.
Article
Chemistry, Analytical
Pamula Sri Sruthi, Sivasamy Balasubramanian, Ponnusamy Senthil Kumar, Ashish Kapoor, Muthamilselvi Ponnuchamy, Meenu Mariam Jacob, Sivaraman Prabhakar
Summary: This study developed a miniaturized paper-based pH detection platform using natural dye extracted from red cabbage. The device's performance at different pH values was quantitatively assessed through digital image analysis, and the a* parameter in the CIEL*a*b* color space model was used for quantifying pH variations. The simplicity of fabrication, eco-friendliness due to the use of paper and natural dye, and suitability for in situ pH measurements make this methodology promising for future chemical sensor technologies.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Aziz Ur Rehman Aziz, Mengjie Fu, Jiu Deng, Chunyang Geng, Yong Luo, Bingcheng Lin, Xiaohui Yu, Bo Liu
Article
Engineering, Multidisciplinary
Yanxia Wang, Yu Wang, Siqi Li, Aziz Ur Rehman Aziz, Shutian Liu, Kairong Qin
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2018)
Article
Engineering, Electrical & Electronic
Chunyang Geng, Chiyu Li, Wang Li, Wo Yan, Jing Li, Aziz Ur Rehman Aziz, Xiaofeng Zhai, Weibing Sun, Bo Liu
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2018)
Review
Biochemistry & Molecular Biology
Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang, Bo Liu
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Toxicology
Aziz Ur Rehman Aziz, Chunyang Geng, Wang Li, Xiaohui Yu, Kai-Rong Qin, Hanqin Wang, Bo Liu
TOXICOLOGICAL SCIENCES
(2019)
Article
Cell Biology
Fei Xie, Shuai Shao, Baohong Zhang, Sha Deng, Aziz Ur Rehman Aziz, Xiaoling Liao, Bo Liu
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Toxicology
Aziz Ur Rehman Aziz, Xiaohui Yu, Qingyun Jiang, Youyi Zhao, Sha Deng, Kairong Qin, Hanqin Wang, Bo Liu
TOXICOLOGY IN VITRO
(2020)
Review
Biochemical Research Methods
Tingting Han, Yuhang Jin, Chunyang Geng, Aziz Ur Rehman Aziz, Yang Zhang, Sha Deng, Haijun Ren, Bo Liu
Article
Biochemical Research Methods
Yunong Yang, Yongjiang Li, Miao Yu, Chundong Xue, Bo Liu, Yanxia Wang, Kairong Qin
Summary: This study developed a passive pump-assisted microfluidic assay to quantify endothelial wound healing in response to fluid shear stress. The method was validated using numerical simulations and fluorescein experiments, and the acceleration of wound healing under shear stress was observed.
Article
Biochemistry & Molecular Biology
Baohong Zhang, Fei Xie, Aziz Ur Rehman Aziz, Shuai Shao, Wang Li, Sha Deng, Xiaoling Liao, Bo Liu
Article
Multidisciplinary Sciences
Wang Li, Xinlei Yu, Fei Xie, Baohong Zhang, Shuai Shao, Chunyang Geng, Aziz Ur Rehman Aziz, Xiaoling Liao, Bo Liu
Article
Mathematics, Applied
Zongzheng Chen, Weimo Yuan, A. R. Aziz, Zhengming Gao, Depei Zeng, Bo Liu, Kairong Qin
APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION
(2017)
Review
Biochemistry & Molecular Biology
Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang, Bo Liu