Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gehan Botrus, Richard M. Miller, Pedro Luiz Serrano Uson Jr, Geoffrey Kannan, Haiyong Han, Daniel D. Von Hoff
Summary: High levels of ER stress and UPR activation are present in pancreatic cancer, leading to adaptive mechanisms and potential apoptosis. This review discusses the mechanisms by which compounds activate the UPR pathways and induce apoptosis, and explores the potential of ER stress inducers for anti-tumor efficacy in pancreatic cancer. A new approach of increasing ER stress and UPR activation to incite apoptotic cell death in pancreatic cancer is hypothesized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Maria De Benedictis, Antonia Gallo, Danilo Migoni, Paride Papadia, Pietro Roversi, Angelo Santino
Summary: We studied the response of Arabidopsis thaliana to chronic and temporary Cd2+ stress, finding that Cd2+ induces ER stress and unfolded protein response (UPR) through the bZIP60 arm. The UPR activation is concentration- or time-dependent and leads to the activation of ER stress marker genes. Severe Cd2+ stress triggers programmed cell death (PCD) through NAC089 activation. The Atbzip28/bzip60 double mutant shows reduced UPR and PCD, as well as enhanced Cd2+ tolerance, possibly due to increased brassinosteroids signaling.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Wolfgang Vivas, Sebastian Weis
Summary: Pathogens and their toxic byproducts can cause tissue damage in infected hosts, triggering stress responses such as the unfolded protein response (UPR) to limit pathogenesis. However, prolonged or excessive activation of UPR may have detrimental effects including cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Yuki Ishiwata-Kimata, Yukio Kimata
Summary: This article reviews the canonical and up-to-date insights regarding yeast UPR, mainly focusing on the functions and regulation of Ire1 and HAC1.
Review
Biochemistry & Molecular Biology
Noel Verjan Garcia, Kyung U. Hong, Nobuyuki Matoba
Summary: The endoplasmic reticulum (ER) plays a vital role in cell homeostasis and disruptions to its functions can lead to diseases. Dysregulated ER stress and UPR are linked to various human diseases, including inflammatory bowel disease (IBD). A recent study has shown that EPICERTIN can induce a protective UPR in colon epithelial cells, promoting mucosal healing in IBD models.
Review
Cell Biology
Xun Gao, Yuanyuan Xu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi'u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar
Summary: The endoplasmic reticulum (ER) is vital for cellular functions, but disruptions in its homeostasis can lead to ER stress, linked to diseases like cancer, obesity, and diabetes. The mechanisms of ER stress related to chronic hyperglycemia and hyperlipidemia in type II diabetes remain unclear.
Article
Biology
Mateusz Kowalczyk, Edward Kowalczyk, Pawel Kwiatkowski, Lukasz Lopusiewicz, Monika Talarowska, Monika Sienkiewicz
Summary: Despite numerous scientific studies on depression, there is still no clear understanding of the causes and mechanisms of depression development. Recent research has found a strong relationship between depression and endoplasmic reticulum (ER) stress, with continuous activation of stress response pathways in patients. Therefore, recommended drugs should aim at reducing ER stress while alleviating symptoms of depression.ongoing search for drugs that can effectively reduce ER stress and relieve depression symptoms.
Review
Plant Sciences
Sofia Reyes-Impellizzeri, Adrian A. Moreno
Summary: This review focuses on the impact of alterations in components of ERQC, ERAD, and UPR on plant responses to abiotic stresses. Evidence shows a clear connection between ERAD and UPR mechanisms, but the connection of ERQC components with these processes or their possible client proteins is lacking. Proteomics approaches are suggested to uncover the identity of these proteins and their connection to ER proteostasis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Anja Batel, Mirjana Polovic, Mateo Glumac, Oliver Suman, Stipislav Jadrijevic, Bernarda Lozic, Marija Petrovic, Bobana Samardzija, Nicholas J. Bradshaw, Karlo Skube, Vinko Palada, Mislav Acman, Ivana Marinovic Terzic
Summary: This study reveals the role of the SPRTN gene in hepatocellular carcinoma (HCC) and its association with endoplasmic reticulum (ER) stress, providing new insights into the pathogenesis of HCC.
CANCER GENE THERAPY
(2023)
Review
Oncology
Pengfei Shi, Zhuohang Zhang, Jie Xu, Li Zhang, Hongjuan Cui
Summary: ER stress can induce apoptosis in cells, and it is significant for glioblastoma as it may increase sensitivity to temozolomide.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Bowen Qing, Song Wang, Yingan Du, Can Liu, Wei Li
Summary: Endoplasmic reticulum stress is a cell response to stress and its abnormal activation can influence tumor development and treatment efficacy. Investigating the molecular mechanism of ERS can help solve drug resistance in tumors and provide a novel strategy for treating refractory tumors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rina Carrillo, David A. Christopher
Summary: A unique biosensor-reporter system was developed to measure UPR activation in plants under stressful environments, demonstrating its utility in Arabidopsis leaf protoplasts for visualization and quantification using confocal microscopy.
PLANT SIGNALING & BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Hyung Don Ryoo
Article
Medicine, Research & Experimental
Bo-Yun Jang, Hyung Don Ryoo, Jaekyoung Son, Kyung-Chul Choi, Dong-Myoung Shin, Sang-Wook Kang, Min-Ji Kang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Review
Neurosciences
B. Mollereau, N. M. Rzechorzek, B. D. Roussel, M. Sedru, D. M. Van den Brink, B. Bailly-Maitre, F. Palladino, D. B. Medinas, P. M. Domingos, S. Hunot, S. Chandran, S. Birman, T. Baron, D. Vivien, C. B. Duarte, H. D. Ryoo, H. Steller, F. Urano, E. Chevet, G. Kroemer, A. Ciechanover, E. J. Calabrese, R. J. Kaufman, C. Hetz
Article
Biochemistry & Molecular Biology
Hyung Don Ryoo
Article
Cell Biology
Min-Ji Kang, Deepika Vasudevan, Kwonyoon Kang, Kyunggon Kim, Jung-Eun Park, Nan Zhang, Xiaomei Zeng, Thomas A. Neubert, Michael T. Marr, Hyung Don Ryoo
JOURNAL OF CELL BIOLOGY
(2017)
Article
Cell Biology
Huai-Wei Huang, Xiaomei Zeng, Taiyoun Rhim, David Ron, Hyung Don Ryoo
JOURNAL OF CELL SCIENCE
(2017)
Review
Cell Biology
Sahana Mitra, Hyung Don Ryoo
JOURNAL OF CELL SCIENCE
(2019)
Review
Neurosciences
Senthilkumar Krishnaswamy, Huai-Wei Huang, Isabella S. Marchal, Hyung Don Ryoo, Einar M. Sigurdsson
NEUROBIOLOGY OF DISEASE
(2020)
Article
Multidisciplinary Sciences
Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo, Hyung Don Ryoo
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Yangkyun Oh, Jason Sih-Yu Lai, Soohong Min, Huai-Wei Huang, Stephen D. Liberles, Hyung Don Ryoo, Greg S. B. Suh
Summary: Two satiety signals inhibiting DH44 nutrient sensor activity have been identified: Piezo-mediated stomach/crop stretch and Neuromedin/Hugin neurosecretory neurons activated by an increase in internal glucose levels. These signals work together to regulate DH44 sensor activity in fed flies.
Article
Developmental Biology
Sahana Mitra, Hyung Don Ryoo
Summary: Mutation in the Ire1 gene leads to changes in eye color and Rhodopsin-1 protein levels, affecting the state of pigment granules in adult Drosophila eyes.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Deepika Vasudevan, Hidetaka Katow, Huai-Wei Huang, Grace Tang, Hyung Don Ryoo
Summary: Metazoans have developed various quality control mechanisms to deal with cellular stress, including the major effector ATF4 in the integrated stress response pathway. Loss of Drosophila ATF4 results in lethality during pupal development, and the role of the gene cryptocephal (crc) in disease models and tissue homeostasis remains unclear. A protein-trap Minos-mediated integration insertion in the crc locus generates a Crc-GFP fusion protein, uncovering unknown roles for crc in development, cellular homeostasis, and photoreceptor survival.
DISEASE MODELS & MECHANISMS
(2022)
Article
Genetics & Heredity
Huai-Wei Huang, Hyung Don Ryoo
Summary: This study highlights the role of Drosophila fatty acid binding protein (fabp) in regulating light-dependent Rhodopsin-1 (Rh1) proteostasis and photoreceptor survival. The induction of fabp in ninaE(G69D) mutant photoreceptors required vitamin A and its transporter genes, showing a link between nutrients and protein clearance. Loss of fabp resulted in accumulation of Rh1 proteins in cytoplasmic vesicles, leading to light-dependent retinal degeneration.
Article
Biology
Brian Brown, Sahana Mitra, Finnegan D. Roach, Deepika Vasudevan, Hyung Don Ryoo
Summary: The study identified a novel UPR signaling axis composed of PERK and Xrp1, which is independent of ATF4 and induces antioxidant genes.
Review
Biochemistry & Molecular Biology
Hyung Don Ryoo, Deepika Vasudevan