Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Neeraj Kumar Fuloria, Shivkanya Fuloria, Sk Batin Rahman, Waleed Hassan Al-Malki, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Sachin K. Singh, Venkata Sita Rama Raju Allam, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: NF-xB is a crucial transcription factor involved in inflammation, immune response, and various physiological processes, playing a key role in many respiratory disorders.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Xin Shi, Shaopin Zhu, Huiyi Jin, Junwei Fang, Xindan Xing, Yihan Wang, Hanying Wang, Chingyi Wang, Tian Niu, Kun Liu
Summary: The study revealed that KS23 had therapeutic effects on endotoxin-induced uveitis in rats, reduced infiltration of inflammatory cells, and levels of inflammatory cytokines. It also showed inhibitory effects on LPS-stimulated RAW 264.7 cells, suggesting KS23 as a promising therapeutic candidate for ocular inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
SangJoon Mo, Eun Young Kim, Yi-Suk Kwon, Min Young Lee, Jin Chul Ahn
Summary: Inflammation is the body's response to harmful agents. Macrophages play a key role in this process and can modulate the immune response. Organic light-emitting diodes (OLEDs) show potential for treating inflammatory conditions by reducing morphological changes and inflammatory cytokine expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Linglian Kong, Yuanli Cai, Xue Pan, Chuanpi Xiao, Zhigang Song
Summary: The study found that glycerol monolaurate (GML) can improve intestinal morphology, enhance antioxidant capacity, and exert its effects by alleviating inflammatory responses and modulating NF-kB signaling.
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yixin Han, Xiaoyu Zhang, Yuan Kang, Yuan Gao, Ximeng Li, Ruijuan Qi, Runlan Cai, Yun Qi
Summary: The study found that sophoraflavanone M (SFM) has anti-inflammatory effects, reducing the production of inflammatory mediators in vivo and in vitro. SFM acts on both NF-κB and JNK/AP-1 signaling pathways, indicating its potential as a natural candidate for alleviating inflammatory conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hajime Honjo, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Summary: Inflammatory bowel diseases (IBDs) are increasing worldwide, with many patients showing refractoriness to current treatments. Therefore, the search for novel therapeutic targets, such as RIPK2, is crucial. Experimental and clinical studies have implicated RIPK2 in the development of autoimmune diseases, particularly IBD, suggesting its potential as a new therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yu Xian Goh, Juriyati Jalil, Kok Wai Lam, Khairana Husain, Chandini Menon Premakumar
Summary: Non-resolving inflammation is a major trigger in various diseases, and patients are seeking natural compounds, such as genistein, as alternative medicine due to the undesirable effects of anti-inflammatory drugs. Previous studies have shown that genistein has strong anti-inflammatory activities by inhibiting various signaling pathways and mediators. However, evidence for its pharmacological effects is still lacking, and further studies are needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Daniel Arthur Corpuz Fisher, Jared Scott Fowles, Amy Zhou, Stephen Tracy Oh
Summary: Myeloid neoplasms such as AML, MPNs, and MDS involve clonal dominance and remodeling of bone marrow niche leading to malignant hematopoiesis. Inflammatory signaling hyperactivation and cytokine overproduction play critical roles, with cytokines like TNF potentially contributing to malignant clonal dominance. Targeting cytokine-mediated signaling may be a promising therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Na Yang, Minxiu Wang, Ke Lin, Mengyang Wang, Diyun Xu, Xue Han, Xia Zhao, Yi Wang, Gaojun Wu, Wu Luo, Guang Liang, Peiren Shan
Summary: The study demonstrates that Dectin-1 plays a critical role in the pathogenesis of diabetic cardiomyopathy by regulating inflammation. Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Dectin-1 may be a potential target for the treatment of diabetic cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Gastroenterology & Hepatology
Mary Ayers, Karis Kosar, Yuhua Xue, Chhavi Goel, Matthew Carson, Elizabeth Lee, Silvia Liu, Eva Brooks, Pamela Cornuet, Michael Oertel, Bharat Bhushan, Kari Nejak-Bowen
Summary: Inhibiting Wnt signaling can alleviate hepatic injury and inflammation in a mouse model of cholestasis, and disrupt the nuclear factor kappa B-dependent inflammatory axis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)