期刊
PEPTIDES
卷 31, 期 6, 页码 1159-1164出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2010.03.014
关键词
Angiotensin II; Src; Protein kinase C zeta; Vascular smooth muscle cells
资金
- National Nature Science Foundation of China [30871014, 30800372]
- National Basic Research Program of China (973 program) [2007CB512004]
Protein kinase C zeta (PKC zeta) isoform plays a critical role in angiotensin II (AngII)-elicited extracellular signal-regulated kinase 1/2 (ERK1/2) activation and proliferation in vascular smooth muscle cells (VSMCs). However, the exact signal transduction mechanism by which AngII activates PKC zeta has not been clarified. In this study, we investigated the role of Src in PKC zeta activation and VSMCs proliferation induced by AngII. AngII-induced rapid activation of PKC zeta, which was associated with its phosphorylation and nuclear translocation. AngII not only induced Src activation but also promoted the physical association between Src and PKC zeta, which was abolished by Src inhibition with PP2. Src inhibition also abrogated AngII-stimulated PKC zeta activation, ERK1/2 phosphorylation and VSMCs proliferation. In conclusion, Src kinase plays an important role in AngII-elicited PKC zeta activation and the subsequent downstream signaling including ERK1/2 activation and VSMCs proliferation. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据