Review
Multidisciplinary Sciences
Ioana Saulescu, Ruxandra Ionescu, Daniela Opris-Belinski
Summary: Although perceived as an adaptative immune disorder, last years' focus on Systemic Lupus Erythematosus (SLE) pathogeny emphasized the important role of innate immunity. Failure of the immune mechanisms to preserve the balance between autoinflammation and autoimmunity initiates and propagates SLE, with interferon being a key cytokine in this process.
Article
Immunology
Juliana Imgenberg-Kreuz, Johanna K. Sandling, Katrine Braekke Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Ann-Christine Syvanen, Elisabet Svenungsson, Lars Ronnblom, Maija-Leena Eloranta, Gunnel Nordmark
Summary: The study introduced a DNA methylation-based IFN score to identify patients with activation of the IFN system in primary Sjogren's syndrome (pSS). High DNAm IFN scores were associated with younger age at symptom onset and diagnosis, positive SSA and SSB antibodies, hypergammaglobulinemia, low C4, and lymphoma in pSS patients. The DNAm IFN score could be a promising tool for patient stratification, treatment decisions, monitoring, and inclusion in clinical trials.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Tatiana Montoya, Maria Luisa Castejon, Rocio Munoz-Garcia, Catalina Alarcon-de-la-Lastra
Summary: Epigenetic modifications play a crucial role in the development and predisposition of autoimmune diseases, such as systemic lupus erythematosus (SLE). Environmental factors can affect gene expression through epigenetic mechanisms, and diet is one of the most important factors that can influence these alterations. Understanding the cross-link between epigenetic mechanisms, SLE, and dietary factors may lead to novel personalized therapies for SLE patients.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Masahiro Nakano, Mineto Ota, Yusuke Takeshima, Yukiko Iwasaki, Hiroaki Hatano, Yasuo Nagafuchi, Takahiro Itamiya, Junko Maeda, Ryochi Yoshida, Saeko Yamada, Aya Nishiwaki, Haruka Takahashi, Hideyuki Takahashi, Yuko Akutsu, Takeshi Kusuda, Hiroyuki Suetsugu, Lu Liu, Kwangwoo Kim, Xianyong Yin, So-Young Bang, Yong Cui, Hye-Soon Lee, Hirofumi Shoda, Xuejun Zhang, Sang-Cheol Bae, Chikashi Terao, Kazuhiko Yamamoto, Tomohisa Okamura, Kazuyoshi Ishigaki, Keishi Fujio
Summary: This study conducted a large-scale transcriptome analysis to understand the dysregulated gene expression patterns in systemic lupus erythematosus (SLE). The researchers identified cell-type-specific transcriptomic signatures associated with disease establishment and exacerbation. The study suggested the clinical value of disease-activity signatures in predicting organ involvement and therapeutic responses.
Review
Immunology
Antonio Marinho, Jose Delgado Alves, Jorge Fortuna, Raquel Faria, Isabel Almeida, Gloria Alves, Joao Araujo Correia, Ana Campar, Mariana Brandao, Jorge Crespo, Daniela Marado, Joao Matos-Costa, Susana Oliveira, Fernando Salvador, Lelita Santos, Fatima Silva, Milene Fernandes, Carlos Vasconcelos
Summary: "Evidence and practice-based guidance for off-label use of biologics in SLE, APS, and SS: a comprehensive literature review and expert consensus resulted in 32 final recommendations, considering organ involvement, manifestations, severity, and response to previous treatments."
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dario Roccatello, Roberta Fenoglio, Ilaria Caniggia, Joelle Kamgaing, Carla Naretto, Irene Cecchi, Elena Rubini, Daniela Rossi, Emanuele De Simone, Giulio Del Vecchio, Martina Cozzi, Savino Sciascia
Summary: This study presents a case series of six patients with refractory lupus nephritis who were treated with an off-label anti-CD38 monoclonal antibody. Five patients achieved complete or partial renal responses after 12 months of follow-up. These findings suggest that daratumumab monotherapy shows promise as a potential treatment for refractory lupus nephritis.
Article
Immunology
Mathilde Labouret, Stefania Costi, Vincent Bondet, Vincent Trebossen, Enora Le Roux, Alexandra Ntorkou, Sophie Bartoli, Stephane Auvin, Brigitte Bader-Meunier, Veronique Baudouin, Olivier Corseri, Glory Dingulu, Camille Ducrocq, Cecile Dumaine, Monique Elmaleh, Nicole Fabien, Albert Faye, Isabelle Hau, Veronique Hentgen, Theresa Kwon, Ulrich Meinzer, Naim Ouldali, Cyrielle Parmentier, Marie Pouletty, Florence Renaldo, Isabelle Savioz, Flore Rozenberg, Marie-Louise Fremond, Alice Lepelley, Gillian I. Rice, Luis Seabra, Jean-Francois Benoist, Darragh Duffy, Yanick J. Crow, Pierre Ellul, Isabelle Melki
Summary: This study aimed to identify central nervous system (CNS) disease biomarkers of juvenile neuropsychiatric SLE (j-NPSLE). The results showed that cerebrospinal fluid (CSF) levels of neopterin and interferon-alpha (IFN-alpha) protein were significantly higher in active j-NPSLE cases with CNS involvement compared to j-SLE alone. These biomarkers could potentially be useful in the diagnosis and monitoring of j-NPSLE activity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Richard K. Perez, M. Grace Gordon, Meena Subramaniam, Min Cheol Kim, George C. Hartoularos, Sasha Targ, Yang Sun, Anton Ogorodnikov, Raymund Bueno, Andrew Lu, Mike Thompson, Nadav Rappoport, Andrew Dahl, Cristina M. Lanata, Mehrdad Matloubian, Lenka Maliskova, Serena S. Kwek, Tony Li, Michal Slyper, Julia Waldman, Danielle Dionne, Orit Rozenblatt-Rosen, Lawrence Fong, Maria Dall'Era, Brunilda Balliu, Aviv Regev, Jinoos Yazdany, Lindsey A. Criswell, Noah Zaitlen, Chun Jimmie Ye
Summary: By using mux-seq technology, we conducted extensive single-cell RNA sequencing on peripheral blood cells from SLE patients and healthy individuals. We found increased expression of type 1 interferon-stimulated genes in monocytes, reduced naive CD4(+) T cells, and expanded cytotoxic CD8(+) T cells in SLE patients. The cell type-specific expression features could predict the case-control status and classify patients into two molecular subtypes. Furthermore, we linked SLE-associated genetic variants to cell type-specific expression using genotyping data.
Article
Cardiac & Cardiovascular Systems
Romy Boehme, Christoph Daniel, Fulvia Ferrazzi, Miriam Angeloni, Arif Buelent Ekici, Thomas H. Winkler, Karl-Friedrich Hilgers, Ute Wellmann, Reinhard E. Voll, Kerstin Amann
Summary: This study investigated the effect of lupus nephritis on the development of cardiovascular changes and found that the cardiovascular changes in patients with systemic lupus erythematosus (SLE) were correlated with renal damage progression. Additionally, the expression of lupus-specific inflammatory factors and complement deposition may also influence cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Rheumatology
Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T. Boumpas, George K. Bertsias
Summary: A machine learning algorithm was developed to assist in the diagnosis of SLE by analyzing patient data sets, leading to improved diagnostic and treatment outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Menglan Zhang, Leiwen Peng, Wensheng Li, Yifei Duan, Xiaoqin Liu, Shasha Chen, Jiamin Deng, Xinle Liu
Summary: This study found that IL12B polymorphisms are associated with the susceptibility of JIA and JSLE in Chinese children. The rs3212227 genotype is significantly associated with an increased risk of JSLE, while the rs6887695 genotype is significantly associated with an increased risk of JIA. Additionally, the IL12B haplotype GC is significantly associated with an increased risk of JIA. However, there is no significant difference in the IL17 gene polymorphisms between JIA and JSLE susceptibility.
Review
Biochemistry & Molecular Biology
Wojciech Lubon, Malgorzata Lubon, Przemyslaw Kotyla, Ewa Mrukwa-Kominek
Summary: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with up to one-third of patients experiencing various ocular manifestations. Ocular findings may be the initial signs of the disease and can lead to severe complications and vision loss. Early diagnosis and proper management are crucial, requiring collaboration among specialists. Adequate preparation of ophthalmologists can help differentiate SLE complications from other eye disorders. New therapies for SLE show promise, but their ocular side effects are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Madhu Ramaswamy, Raj Tummala, Katie Streicher, Andre Nogueira da Costa, Philip Z. Brohawn
Summary: Systemic lupus erythematosus (SLE) presents a challenging treatment landscape due to its multifaceted etiology and complex immunopathogenesis. While targeting the B-cell pathway has limitations, recent approval of anifrolumab, a type I interferon-blocking antibody, highlights the therapeutic potential of targeting the dysregulated interferon pathway in SLE patients. Further research into the pleiotropic biology of interferons and their intersection with SLE disease pathology will be crucial for the development of effective targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Xinyi Meng, Xiaoyuan Hou, Ping Wang, Joseph T. Glessner, Hui-Qi Qu, Michael E. March, Sipeng Zhang, Xiaohui Qi, Chonggui Zhu, Kenny Nguyen, Xinyi Gao, Xiaoge Li, Yichuan Liu, Wentao Zhou, Shuyue Zhang, Junyi Li, Yan Sun, Jie Yang, Patrick M. A. Sleiman, Qianghua Xia, Hakon Hakonarson, Jin Li
Summary: This study identified rare coding variants in JIA patients using RNA-seq data, including some reported causal variants. These variants were partially replicated in polyarticular patients and shared common variants with genes associated with autoimmune diseases. Genes related to immune pathways were enriched for rare coding variants and differentially expressed genes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
Summary: This study estimated the epidemiology of SLE globally, finding variations in incidence and prevalence rates across different countries and regions. It also highlighted the impact of gender, age, and prevalence estimation method on the findings. SLE was found to occur more frequently in high-income countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
J. L. Cordeiro, J. D. Neves, F. Nicola, A. F. Vizuete, E. F. Sanches, C. A. Goncalves, C. A. Netto
Summary: In this study, arundic acid (AA) was administered in a collagenase-induced intracerebral hemorrhage (ICH) rodent model, and it was found that AA could prevent motor dysfunction, reduce S100B levels, and decrease astrogliosis and microglial activation, which in turn led to a decrease in the production of proinflammatory cytokines and reactive oxygen species (ROS).
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Bichismita Sahu, Santosh Kumar Behera, Rudradip Das, Tanay Dalvi, Arnab Chowdhury, Bhaskar Dewangan, Kiran Kalia, Amit Shard
Summary: This study designed scaffolds derived from peptide nucleic acid (PNA) and conducted in-silico screening to identify a compound with similar binding affinity to RdRp. Compound 12 showed comparable pharmacokinetics to remdesivir but with significantly lower toxicity, making it a potential candidate for the treatment of COVID-19.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Ophthalmology
Massimiliano Serafino, Andrea Lembo, Matteo Scaramuzzi, Andrea Dellavalle, Paolo Nucci
Summary: Pulled-in-two syndrome is a serious complication of strabismus surgery, where an extraocular muscle is ruptured. Transposition of the inferior oblique muscle can be a potential technique for treatment if the muscle cannot be retrieved.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jin Kyun Oh, Yan Nuzbrokh, Winston Lee, Jose Ronaldo Lima de Carvalho, Nan Kai Wong, Janet Sparrow, Rando Alliikmets, Stephen H. Tsang
Summary: This case report describes two brothers with progressive vision loss and night blindness, showing typical symptoms of pigmented paravenous retinochoroidal atrophy. Genetic analysis revealed a mutation in the CRX gene in both individuals.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Psychology, Clinical
L. A. Rescorla, M. Y. Ivanova, T. M. Achenbach, Vera Almeida, Meltem Anafarta-Sendag, Ieva Bite, J. Carlos Caldas, John William Capps, Yi-Chuen Chen, Paola Colombo, Margareth da Silva Oliveira, Anca Dobrean, Nese Erol, Alessandra Frigerio, Yasuko Funabiki, Reda Gedutiene, Halldor S. Guomundsson, Min Quan Heo, Young Ah Kim, Tih-Shih Lee, Manuela Leite, Jianghong Liu, Jasminka Markovic, Monika Misiec, Marcus Mueller, Kyung Ja Oh, Veronica Portillo-Reyes, Wolfgang Retz, Sandra B. Sebre, Shupeng Shi, Sigurveig H. Siguroardottir, Roma Simulioniene, Elvisa Sokoli, Dragana Milijasevic, Ewa Zasepa
Summary: This study compares self-reports and collateral reports of older adults' mental health across 19 societies, finding that the OASR and OABCL are efficient assessments that can be used internationally to screen for various problems and strengths.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Nikhil Maroli, Balu Bhasuran, Jeyakumar Natarajan, Ponmalai Kolandaivel
Summary: This study utilized text mining and named entity recognition methods to identify the co-occurrence of important COVID 19 genes/proteins in the interaction network. Molecular docking and molecular dynamics simulation revealed the inhibition mechanism of key proteins and confirmed the affinity of procyanidin towards critical receptors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Public, Environmental & Occupational Health
Anya P. G. F. Vieira-Meyer, Maira B. Coutinho, Helena P. G. Santos, Maria Saintrain, George T. de M. Candeiro
Summary: This study investigated the knowledge and practice of Brazilian public primary and secondary health care dentists during the COVID-19 pandemic. The majority of these dentists believed in the transmission of COVID-19 through dental procedures, but had a fair level of knowledge about COVID-19 symptoms. There was skepticism about the effectiveness of personal protective equipment and biosafety procedures in preventing COVID-19 transmission. Factors such as country region, social distancing, dental specialty, and the use of protective measures influenced the likelihood of dentists performing dental treatment during the pandemic. The study concludes that additional preventive measures and internationally accepted guidelines are needed to address the challenges brought by COVID-19.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Public, Environmental & Occupational Health
Eugenia O'Kelly, Anmol Arora, Charlotte Pearson, James R. Ward, P. John Clarkson
Summary: This study evaluates alternatives and replacement methods for qualitative fit testing. It found that aroma diffusers and smaller enclosures can perform the testing quickly and accurately.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Rehabilitation
Danielle Brasil-Barros-da-Silva, Emerson Fachin-Martins
Summary: This study aimed to explore the association between the usage of forearm crutches and pain complaints and health conditions. The study found different patterns of pain complaints between permanent and temporary users, with temporary female users more likely to be injured due to external causes. Additionally, both types of users reported varying levels of pain, with only permanent users reporting mild pain.
ASSISTIVE TECHNOLOGY
(2022)
Article
Psychology, Multidisciplinary
Lia Ring, Lee Greenblatt-Kimron, Yuval Palgi
Summary: This study aimed to examine whether subjective nearness-to-death moderated the association between health worries and death anxiety due to the COVID-19 outbreak among older adults in Israel. The findings revealed that subjective nearness-to-death moderated the association between health worries and death anxiety. The importance and significance of subjective perceptions concerning the distance from death as a resilient resource is discussed.