Article
Virology
Ricarda Cortes-Vieyra, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor Manuel Baizabal-Aguirre, Rosa Elvira Nunez-Anita, Angelica Georgina Rocha-Lopez, Anel Gomez-Garcia
Summary: The study found that the eosinophil counts in COVID-19 recovered patients increased more rapidly during the disease progression, while eosinopenia was more frequently observed in deceased patients. The survival rate of patients without eosinopenia was higher than those with eosinopenia.
Article
Medical Laboratory Technology
Nisa Cetin Kargin
Summary: This study found that serum neutrophil, NLR, and ferritin levels were found to be higher in current smokers/ex-smokers, indicating a poor prognosis of COVID-19 associated with smoking.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Medicine, General & Internal
Huan Yang, Yuan Xu, Zhijie Li, Ling Yan, Jing Wang, Pu Liao
Summary: This study analyzed the clinical characteristics of COVID-19 patients in Chongqing, identifying differences in lymphocyte and neutrophil levels between severe and non-severe groups. The study also found dynamic changes in blood routine analyzing items at different stages of illness, with potential for distinguishing severe cases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Andrei-Costin Chelariu, Adorata Elena Coman, Catalina Lionte, Victoria Gorciac, Victorita Sorodoc, Raluca Ecaterina Haliga, Ovidiu Rusalim Petris, Cristina Bologa, Gabriela Puha, Alexandra Stoica, Mihai Constantin, Oana Sirbu, Alexandr Ceasovschih, Laurentiu Sorodoc
Summary: This prospective cohort study assessed the prognostic value of scores based on complete blood count (CBC) in hospitalized COVID-19 patients. The results indicate that the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) can predict the need for intensive care unit (ICU) therapy and short-term mortality in mild or moderate COVID-19 patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Virology
Fesih Ok, Omer Erdogan, Emrullah Durmus, Serkan Carkci, Aggul Canik
Summary: The study identified that the blood urea nitrogen/creatinine ratio and neutrophil to lymphocyte ratio are independent predictors for the severity and survival of COVID-19. Routine evaluation of these parameters can help in identifying high-risk cases with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Allergy
Guogang Xie, Fengming Ding, Lei Han, Dongning Yin, Hongzhou Lu, Min Zhang
Summary: The majority of COVID-19 patients had a decrease in circulating EOS counts, which had good predictive value for the disease. Patients with low EOS counts at admission were more likely to have symptoms, more severe chest CT findings, and a longer course of illness compared to those with normal EOS counts.
Article
Medicine, General & Internal
Sara J. Ruiz, Paula S. Ventura, Jose M. C. Vazquez, Salvador I. Garcia-Adasme, Mario M. Garcia, Paula T. Pol, Isabel L. Martin, Alejandro L. Escobar
Summary: NLR, as a marker of endothelial dysfunction, may be useful in identifying patients with a poor prognosis in hospitalized COVID-19 cases. Patients with worse outcomes were older, had significantly higher NLR values at admission, greater increase in Peak NLR, and higher increasing speed of NLR compared with follow-up patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Jingjing Cai, Haomiao Li, Changjiang Zhang, Ze Chen, Hui Liu, Fang Lei, Juan-Juan Qin, Ye-Mao Liu, Feng Zhou, Xiaohui Song, Jianghua Zhou, Yan-Ci Zhao, Bin Wu, Meiling He, Huilin Yang, Lihua Zhu, Peng Zhang, Yan-Xiao Ji, Guang-Nian Zhao, Zhigang Lu, Liming Liu, Weiming Mao, Xiaofeng Liao, Haofeng Lu, Daihong Wang, Xigang Xia, Xiaodong Huang, Xiang Wei, Jiahong Xia, Bing-Hong Zhang, Yufeng Yuan, Zhi-Gang She, Qingbo Xu, Xinliang Ma, Yibin Wang, Juan Yang, Xin Zhang, Xiao-Jing Zhang, Hongliang Li
Summary: The study suggests that corticosteroid therapy is beneficial for non-diabetic COVID-19 patients with severe symptoms, identified by a neutrophil-to-lymphocyte ratio (NLR) > 6.11 at admission. However, it also indicates that corticosteroid treatment may increase risks of hyperglycemia and infections for patients with an NLR <= 6.11 or with type 2 diabetes.
Article
Clinical Neurology
Jia-Hui Hou, Ya-Nan Ou, Wei Xu, Peng-Fei Zhang, Lan Tan, Jin-Tai Yu
Summary: This study found that peripheral immune cells and the ratio of these cells were associated with cognitive function, neuroimaging, and AD pathology. These associations may be mediated by beta-amyloid and tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Zelalem Tadesse, Abdi Bekele Bayissa, Tolesa Diriba, Nahom Chernet, Seniat Tsegaye, Molla Tsega
Summary: This study evaluated the role of NLR in predicting mortality and severity of COVID-19 in African patients, finding that NLR greater than 9.47 and 5.86 can effectively predict mortality and severity, respectively.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Badar Kanwar, Asif Khattak, Richard E. E. Kast
Summary: This study retrospectively compared the survival rates of critically ill COVID-19 patients who received dapsone treatment with those who did not. The results showed a lower mortality rate among patients given dapsone. The study also suggested that dapsone might lower the neutrophil-to-lymphocyte ratio, indicating a potential mechanism of action. However, due to the lack of a control group, no definitive conclusions can be drawn, and further randomized controlled trials are warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Sebastian Carranza Lira, Maritza Garcia Espinosa
Summary: This study found that platelet/lymphocyte ratio was more useful than neutrophil/lymphocyte ratio in detecting pregnant patients with COVID-19 with severe disease.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Oncology
Jun-Qiang Du, Fan Zhang, Chao-Qun Wang, Ju-Fan Zhu, Li-Xia Xu, Yi-Heng Yang, Meng-Fei Han, Yan Hu
Summary: This study analyzed the levels of peripheral blood NLR in 203 patients with early cervical cancer and evaluated the relationship between NLR changes, clinicopathological characteristics, and patient prognosis. The study found that high preoperative NLR was associated with shorter overall survival and high postoperative NLR was associated with lower progression-free survival. Postmenopausal patients and those without vascular infiltration had higher rates of NLR increase. Further multicenter studies are needed to verify the effect of NLR changes on the prognosis of cervical cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Eugene Feigin, Tal Levinson, Asaf Wasserman, Shani Shenhar-Tsarfaty, Shlomo Berliner, Tomer Ziv-Baran
Summary: This study aimed to investigate the association between the two most common inflammatory biomarkers in the emergency department and in-hospital mortality among COVID-19 patients. The results showed that white blood cell count, neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) presented similar discrimination abilities. However, each biomarker should be considered as a predictor for in-hospital mortality in different age groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Sunil Kumar Gothwal, V. B. Singh, Mayank Shrivastava, Ruchita Banseria, Kanika Goyal, Saranshi Singh, Haider Ali, Khalid Saad Alharbi, Yogendra Singh, Gaurav Gupta
Summary: Inflammation plays a crucial role in the development of viral pneumonia, including COVID-19. This study aimed to investigate the prognostic value of various blood markers in COVID-19 patients, and found that hemoglobin, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio were associated with disease severity.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2021)
Article
Respiratory System
Feng Sun, Yang Li, Yu Chen, Wenlong Guan, Xiangao Jiang, Xiaomeng Wang, Pengfei Ren, Junlian Li, Jichan Shi, Guiqing He, Meiying Wu, Peijun Tang, Fei Wang, Yunfeng Sheng, Fuli Huang, Zumo Zhou, Heqing Huang, Liang Hong, Qihui Liu, Ying Zhang, Wenhong Zhang
EUROPEAN RESPIRATORY JOURNAL
(2019)
Article
Infectious Diseases
Yang Li, Fei Wang, Limin Wu, Min Zhu, Guiqing He, Xinchang Chen, Feng Sun, Qihui Liu, Xiaomeng Wang, Wenhong Zhang
INFECTION AND DRUG RESISTANCE
(2019)
Correction
Microbiology
Xinchang Chen, Guiqing He, Shiyong Wang, Siran Lin, Jiazhen Chen, Wenhong Zhang
FRONTIERS IN MICROBIOLOGY
(2019)
Letter
Pediatrics
Guiqing He, Wenjie Sun, Jing Wu, Jing Cai
Letter
Virology
Guiqing He, Wenjie Sun, Peipei Fang, Jianping Huang, Michelle Gamber, Jing Cai, Jing Wu
JOURNAL OF MEDICAL VIROLOGY
(2020)
Letter
Virology
Guiqing He, Jing Wu, Jichan Shi, Jianyi Dai, Michelle Gamber, Xiangao Jiang, Wenjie Sun, Jing Cai
JOURNAL OF MEDICAL VIROLOGY
(2020)
Letter
Virology
Jing Cai, Wenjie Sun, Jianping Huang, Michelle Gamber, Jing Wu, Guiqing He
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Infectious Diseases
Guiqing He, Yang Li, Xinchang Chen, Jiazhen Chen, Wenhong Zhang
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Hongying Yu, Yu Zhang, Xinchang Chen, Guiqing He, Feng Sun, Yongzhong Li, Jiazhen Chen, Wenhong Zhang
INFECTION GENETICS AND EVOLUTION
(2020)
Article
Medical Laboratory Technology
Wenjing Bai, Lingling Liu, Lianpeng Wu, Shanshan Chen, Shuangliao Wu, Zhihui Wang, Ke Xu, Qiong Chi, Yong Pan, Xueqin Xu
Summary: The study found that using the Xpert MTB/RIF assay to analyze BALF samples provides a rapid and accurate tool for the early diagnosis of pulmonary tuberculosis, with higher diagnostic accuracy compared to smear microscopy and TB-DNA. Additionally, Xpert is a quick and accurate method for diagnosing rifampicin-resistant tuberculosis, providing more effective guidance for the treatment of PTB or MDR-TB.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medical Laboratory Technology
Wenjing Bai, Jiangnan Chen, Yijian Mao, Zhihui Wang, Xiaohong Qian, Xingzhong Hu, Ke Xu, Yong Pan
LABORATORY MEDICINE
(2020)
Letter
Immunology
Jing Cai, Wenjie Sun, Jianping Huang, Michelle Gamber, Jing Wu, Guiqing He
EMERGING INFECTIOUS DISEASES
(2020)
Article
Immunology
Jing-Wen Ai, Xian Zhou, Teng Xu, Minling Yang, Yuanyuan Chen, Gui-Qing He, Ningp Pan, Yuwei Cai, Yongjun Li, Xiaorui Wang, Hang Su, Ting Wang, Weiqi Zeng, Wen-Hong Zhang
EMERGING MICROBES & INFECTIONS
(2019)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)