Article
Medicine, General & Internal
Huan Yang, Yuan Xu, Zhijie Li, Ling Yan, Jing Wang, Pu Liao
Summary: This study analyzed the clinical characteristics of COVID-19 patients in Chongqing, identifying differences in lymphocyte and neutrophil levels between severe and non-severe groups. The study also found dynamic changes in blood routine analyzing items at different stages of illness, with potential for distinguishing severe cases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Nisa Cetin Kargin
Summary: This study found that serum neutrophil, NLR, and ferritin levels were found to be higher in current smokers/ex-smokers, indicating a poor prognosis of COVID-19 associated with smoking.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Hasan Dogan, Asli Kara, Erdem cankaya, Eda Balkan, Muhammet Ali Gurbuz, Murat Kizilkaya, Merve Aykac
Summary: This cross-sectional study aimed to evaluate leukocyte DNA damage in COVID-19 patients. DNA damage was detected using the comet assay method. Differences in blood cell counts and DNA damage were observed between COVID-19-positive patients and the control group. COVID-19 infection caused significant increases in DNA damage percentage and was associated with changes in blood cell counts and the neutrophil/lymphocyte ratio.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Sara J. Ruiz, Paula S. Ventura, Jose M. C. Vazquez, Salvador I. Garcia-Adasme, Mario M. Garcia, Paula T. Pol, Isabel L. Martin, Alejandro L. Escobar
Summary: NLR, as a marker of endothelial dysfunction, may be useful in identifying patients with a poor prognosis in hospitalized COVID-19 cases. Patients with worse outcomes were older, had significantly higher NLR values at admission, greater increase in Peak NLR, and higher increasing speed of NLR compared with follow-up patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Public, Environmental & Occupational Health
Monica Gelzo, Sara Cacciapuoti, Biagio Pinchera, Annunziata De Rosa, Gustavo Cernera, Filippo Scialo, Mauro Mormile, Gabriella Fabbrocini, Roberto Parrella, Ivan Gentile, Giuseppe Castaldo
Summary: NLR can be used as a predictive marker of disease severity and mortality in COVID-19 patients. In the first wave, NLR increased significantly with disease severity due to a decrease in lymphocytes and increase in neutrophils. In the second wave, the use of steroids led to no significant differences in NLR among patients of different severity levels.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Zelalem Tadesse, Abdi Bekele Bayissa, Tolesa Diriba, Nahom Chernet, Seniat Tsegaye, Molla Tsega
Summary: This study evaluated the role of NLR in predicting mortality and severity of COVID-19 in African patients, finding that NLR greater than 9.47 and 5.86 can effectively predict mortality and severity, respectively.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Badar Kanwar, Asif Khattak, Richard E. E. Kast
Summary: This study retrospectively compared the survival rates of critically ill COVID-19 patients who received dapsone treatment with those who did not. The results showed a lower mortality rate among patients given dapsone. The study also suggested that dapsone might lower the neutrophil-to-lymphocyte ratio, indicating a potential mechanism of action. However, due to the lack of a control group, no definitive conclusions can be drawn, and further randomized controlled trials are warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kaustav P. Shah, Haocan Song, Fei Ye, Douglas B. Johnson
Summary: In patients with BRAF(V600)-mutated melanoma, the number of distinct tumor sites at the initiation of targeted therapy is associated with survival, while serum lactate dehydrogenase values and the absolute lymphocyte count to absolute neutrophil count ratio are strong predictors of prognosis. Using both of these markers can help stratify prognosis for patients with metastatic melanoma receiving targeted therapy.
Article
Obstetrics & Gynecology
Sebastian Carranza Lira, Maritza Garcia Espinosa
Summary: This study found that platelet/lymphocyte ratio was more useful than neutrophil/lymphocyte ratio in detecting pregnant patients with COVID-19 with severe disease.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Integrative & Complementary Medicine
Sunil Kumar Gothwal, V. B. Singh, Mayank Shrivastava, Ruchita Banseria, Kanika Goyal, Saranshi Singh, Haider Ali, Khalid Saad Alharbi, Yogendra Singh, Gaurav Gupta
Summary: Inflammation plays a crucial role in the development of viral pneumonia, including COVID-19. This study aimed to investigate the prognostic value of various blood markers in COVID-19 patients, and found that hemoglobin, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio were associated with disease severity.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2021)
Article
Medicine, General & Internal
Ibrahim Koc, Sevda Unalli Ozmen
Summary: This study found that cytokine storm in patients with COVID-19 is associated with decreased lymphocyte levels, increased NLR and D-dimer levels, and a history of coronary artery disease and diabetes mellitus.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Virology
Fang Tang, Xiaoshuai Zhang, Bicheng Zhang, Bo Zhu, Jun Wang
Summary: This study developed two nomogram models for distinguishing disease severity and predicting prognosis in COVID-19 patients. The results indicate that immune response phenotyping based on blood indicators can effectively identify high-risk clinical cases.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Infectious Diseases
Yi Zhou, Qiao Yang, Jun Ye, Xiaocheng Wu, Xianhua Hou, Yimei Feng, Bangyu Luo, Jixi Li, Guangrong Yang, Lingchen Li, Xiu Yang, Bin Wang, Songtao Zhao, Li Li, Qi Li, Zhi Xu, Hao Wu, Jianguo Sun
Summary: A retrospective study was conducted on 103 COVID-19 patients with cancer to analyze their clinical features and determine death outcome related risk factors. The study found significant differences in clinical features and laboratory results between severe and non-severe patients, with NLR and CRP identified as predictors of death outcome.
BMC INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Mehr Muhammad Imran, Umair Ahmad, Umer Usman, Majid Ali, Aamir Shaukat, Noor Gul
Summary: This study aimed to investigate the efficacy of NLR as a marker for COVID-19 pneumonia severity in the South-Asian population. Results showed significant correlations between NLR, diabetes prevalence, C-reactive protein, and serum albumin levels. NLR was identified as an independent risk factor for severe COVID-19 pneumonia, suggesting its potential as an early warning signal for deteriorating infection.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Maryam B. Khadzhieva, Ekaterina Kalinina, Sergey S. Larin, Daria A. Sviridova, Alesya S. Gracheva, Julia Chursinova, Vadim A. Stepanov, Ivan Redkin, Lyudmila S. Avdeikina, Alexander G. Rumyantsev, Artem N. Kuzovlev, Lyubov E. Salnikova
Summary: The study revealed that COVID-19 patients with ARDS had lower levels of mature naive T and B cells compared to non-ARDS patients. During hospitalization, ARDS patients showed a higher neutrophil-to-lymphocyte ratio. The analysis of TREC/KREC was negatively correlated with NLR, with the strongest correlation found for TREC per 100,000 cells.
Article
Public, Environmental & Occupational Health
Ming Zhuo, Ze Chen, Mao-Lin Zhong, Ye-Mao Liu, Fang Lei, Juan-Juan Qin, Tao Sun, Chengzhang Yang, Ming-Ming Chen, Xiao-Hui Song, Li-Feng Wang, Yi Li, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Gang Zhou, Yong Zeng
Summary: This study assessed the burden of non-communicable chronic diseases attributable to a diet low in fibre globally from 1990 to 2019. The findings showed an increasing trend in the disability-adjusted life-years rates caused by a low-fibre diet in certain regions, and a rise in the burden of diabetes in some areas.
PUBLIC HEALTH NUTRITION
(2023)
Review
Genetics & Heredity
Ze Chen, Zhao-Xia Jin, Jingjing Cai, Ruyan Li, Ke-Qiong Deng, Yan-Xiao Ji, Fang Lei, Huo-Ping Li, Zhibing Lu, Hongliang Li
Summary: Metabolic cardiomyopathy is a common condition in obese, insulin resistant, and diabetic patients, which is characterized by structural and functional alterations of the heart unrelated to hypertension or coronary artery disease. Oxidative stress plays a crucial role in the development and progression of this condition, with mitochondria being the major source of reactive oxygen species. Disturbances in myocardial substrate metabolism induce mitochondrial dysfunction, leading to an imbalance between fatty acid oxidation and electron transport chain activity, resulting in increased ROS production.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Correction
Biochemistry & Molecular Biology
Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang, Shilong Zhong
CELL AND BIOSCIENCE
(2022)
Article
Endocrinology & Metabolism
Ming Zhuo, Ze Chen, Mao-Lin Zhong, Fang Lei, Juan-Juan Qin, Shuhua Liu, Ye-Mao Liu, Tao Sun, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Erping Yang
Summary: In this study, the association between insulin resistance (IR) and bone mass was evaluated in a Chinese population. The results showed a significant correlation between IR and low bone mass as well as osteoporosis. These findings suggest the importance of bone mass monitoring and early prevention strategies in individuals with IR to prevent the occurrence of low bone mass and osteoporosis.
Article
Cardiac & Cardiovascular Systems
Tao Sun, Zhanpeng Wang, Fang Lei, Lijin Lin, Xingyuan Zhang, Xiaohui Song, Yan-Xiao Ji, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Peng Jia, Hongliang Li
Summary: This study found that long-term exposure to PM2.5 and PM10 is positively associated with atrial fibrillation (AF) prevalence in China. The association is stronger in females, people under 65 years old, and those with hypertension and diabetes. Furthermore, the study identified PM2.5 sulfate as having the highest contribution to the overall mixture effects among all PM2.5 chemical constituents.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemical Research Methods
Yuanyuan Cao, Tao Sun, Zhanpeng Wang, Fang Lei, Lijin Lin, Xingyuan Zhang, Xiaohui Song, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Shujuan Yang, Peng Jia, Jian Li, Hongliang Li
Summary: A study conducted in China revealed the association between PM2.5 exposure and pulmonary nodules, with NO3(-) particles identified as the highest risk factor.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yingying Hu, Fan Zhou, Fang Lei, Lijin Lin, Xuewei Huang, Tao Sun, Weifang Liu, Xingyuan Zhang, Jingjing Cai, Zhi-Gang She, Hongliang Li
Summary: A retrospective cross-sectional study involving 177,540 individuals in the Chinese population shows a nonlinear relationship between thyroid function parameters and metabolic dysfunction-associated fatty liver disease (MAFLD). Higher levels of free triiodothyronine (FT3) are associated with an increased risk of MAFLD when FT3 is less than 5.58pmol/L but a decreased risk when FT3 is greater than or equal to 5.58pmol/L. Additionally, higher levels of free tetra-iodothyronine (FT4) are associated with a decreased risk of MAFLD, while thyroid stimulating hormone (TSH) concentration is positively associated with MAFLD risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fang Lei, Xiao-Ming Wang, Changquan Wang, Xuewei Huang, Ye-Mao Liu, Juan-Juan Qin, Peng Zhang, Yan-Xiao Ji, Zhi-Gang She, Jingjing Cai, Huo-ping Li, Xiao-Jing Zhang, Hongliang Li
Summary: This study investigated the correlation between metabolic dysfunction-associated fatty liver disease (MAFLD) and subclinical carotid atherosclerosis (SCA) in a nationwide population in China. The results showed a significant association between MAFLD and SCA, particularly in individuals with high hepatic steatosis index and young adults.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Xu, Bo Liu, Lijin Lin, Fang Lei, Tao Sun, Xingyuan Zhang, Xiaohui Song, Xuewei Huang, Qiang Zeng, Jingjing Cai, Zhifang Wang, Hongliang Li
Summary: This study found a strong correlation between serum ApoB and CKD, suggesting that high levels of serum ApoB may increase the risk of CKD. Monitoring and reducing serum ApoB levels could be an alternative approach for the prevention and treatment of CKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Haomiao Li, Jiangyun Chen, Dai Su, Xiwu Xu, Ruibo He
Summary: This study aimed to evaluate the impact of frailty and multimorbidity on catastrophic health expenditure (CHE). The results showed that single chronic disease, multimorbidity, and frailty were associated with a higher risk of CHE. The co-occurrence of frailty with a single chronic disease or multimorbidity, and multimorbidity co-occurring with frailty also increased the risk of CHE.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2023)
Article
Cardiac & Cardiovascular Systems
Tao Sun, Mao Ye, Fang Lei, Juan-Juan Qin, Ye-Mao Liu, Ze Chen, Ming-Ming Chen, Chengzhang Yang, Peng Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Zhao-Xia Jin, Hongliang Li
Summary: This study analyzed the recent trends in the prevalence of atrial fibrillation (AF) in China and its age-related disparities in the healthy check-up population. The overall prevalence of AF remained stable at 0.4%-0.45% from 2012 to 2017, but showed an undesirable upward trend in the 35-44 age group. In addition to traditional risk factors, such as age ≥65 and coronary heart disease, elevated uric acid and impaired renal function were tightly correlated with AF in the population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Mengjun Zeng, Haomiao Li, Xiaohui Song, Jipin Jiang, Yingchun Chen
Summary: Improving public willingness toward organ donation is crucial for increasing the organ donation rate. This study investigated the factors influencing public willingness for organ donation in China using a multi-agent perspective and a social-ecological framework. The findings showed that age, family health, gender, educational level, and rural background were negatively associated with willingness. Personality traits, health literacy, perceived social support, and media utilization were positively associated with willingness. It is important to provide targeted education, guidance, and support to different individuals and strengthen media publicity to improve health literacy and enhance the willingness of residents to donate organs.
Article
Psychology, Multidisciplinary
Hui Lv, Haomiao Li
Summary: Exposure to domestic violence (EDV) is associated with an increased risk of depression in later life. This study examines the relationship between EDV during childhood and depressive symptoms in middle and older age. The results show positive associations between parental conflict and corporal punishment, and higher scores of depressive symptoms. Future research should focus on interventions targeting EDV to reduce depression risk and improve mental health in China.
BEHAVIORAL SCIENCES
(2023)
Article
Peripheral Vascular Disease
Lijin Lin, Huxiang Huang, Fang Lei, Tao Sun, Ze Chen, Kun Qin, Manyao Li, Yingying Hu, Xuewei Huang, Xingyuan Zhang, Peng Zhang, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Shujuan Yang, Peng Jia, Hongliang Li
Summary: This study explored the relationship between long-term exposure to PM2.5 and its constituents, and vascular damage in individuals with metabolic abnormalities. The results revealed a significant association between PM2.5 and its constituents with elevated brachial-ankle pulse wave velocity and decreased ankle-brachial index, indicating vascular damage.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Public, Environmental & Occupational Health
Haomiao Li, Yibo Wu, Zhongliang Bai, Xiwu Xu, Dai Su, Jiangyun Chen, Ruibo He, Ju Sun
Summary: Family health has a negative impact on frailty in older adults, with health literacy and health behaviors playing mediating roles. Improving family health can promote healthier lifestyles, improve health literacy, and delay, manage, and reverse frailty.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)