Prolonged-release pirfenidone prevents obesity-induced cardiac steatosis and fibrosis in a mouse NASH model

Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages

(2019) Guanliang Chen et al.   LABORATORY INVESTIGATION

Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats

(2019) Elin Strand et al.   PPAR Research

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin

(2018) Jung Hyun Park et al.   Scientific Reports

Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin β1 InteractionNovelty and Significance

(2017) Abhijit Takawale et al.   HYPERTENSION

Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis

(2017) Chunmei Li et al.   Scientific Reports

Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

(2017) Chikara Komiya et al.   Scientific Reports

The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues

(2017) Elżbieta Supruniuk et al.   Frontiers in Physiology

Insulin Signaling and Heart Failure

(2016) Christian Riehle et al.   CIRCULATION RESEARCH

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

(2016) Ahlke Heydemann   Journal of Diabetes Research

Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts

(2015) Kiyoshi Yamagami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role and New Insights of Pirfenidone in Fibrotic Diseases

(2015) David Alejandro Lopez-de la Mora et al.   International Journal of Medical Sciences

Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice

(2015) Zhi Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitus

(2014) Guillermo Avila et al.   CELL CALCIUM

Cross-talk between heme oxygenase and peroxisome proliferator-activated receptors in the regulation of physiological functions

(2014) Joseph et al.   Frontiers in Bioscience-Landmark

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Pirfenidone attenuates IL-1β-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-κB activity

(2013) Youn-Hee Choi et al.   EXPERIMENTAL EYE RESEARCH

Impact of Obesity and the Obesity Paradox on Prevalence and Prognosis in Heart Failure

(2013) Carl J. Lavie et al.   JACC-Heart Failure

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

(2012) Paul M. Rindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Peroxisome proliferator-activated receptor-γ activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor

(2009) Sang-Hyun Ihm et al.   BASIC RESEARCH IN CARDIOLOGY

Diet-induced obesity increases NF-κB signaling in reporter mice

(2009) Harald Carlsen et al.   Genes and Nutrition

Fatty acid-induced NF-κB activation and insulin resistance in skeletal muscle are chain length dependent

(2008) Pascal P. H. Hommelberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Does Size Matter?

(2008) Frederick E. Dewey et al.   CIRCULATION

Effects of three anti-TNF-α drugs: Etanercept, infliximab and pirfenidone on release of TNF-α in medium and TNF-α associated with the cell in vitro

(2008) K.J. Grattendick et al.   INTERNATIONAL IMMUNOPHARMACOLOGY