Targeting organophosphorus compounds poisoning by novel quinuclidine-3 oximes: development of butyrylcholinesterase-based bioscavengers

Organophosphorus nerve agent poisoning: managing the poisoned patient

(2019) Elspeth J. Hulse et al.   BRITISH JOURNAL OF ANAESTHESIA

Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes

(2019) Tamara Zorbaz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

New and Potent Quinuclidine-Based Antimicrobial Agents

(2019) Andreja Radman Kastelic et al.   MOLECULES

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase

(2019) Zrinka Kovarik et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration

(2018) Tamara Zorbaz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novichok: a murderous nerve agent attack in the UK

(2018) J. Allister Vale et al.   CLINICAL TOXICOLOGY

Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations

(2018) Maja Katalinić et al.   TOXICOLOGY

The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation

(2018) Nikolina Maček Hrvat et al.   TOXICOLOGY LETTERS

Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning

(2018) Michael Eddleston   Annual Review of Pharmacology and Toxicology

Pharmacology, pharmacokinetics and tissue disposition of zwitterionic hydoxyiminoacetamido alkylamines as reactivating antidotes for organophosphate exposure

(2018) Rakesh Sit et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention

(2018) Christopher M. Timperley et al.   PURE AND APPLIED CHEMISTRY

Reversal of tabun toxicity, enabled by a triazole annulated oxime library-reactivators of acetylcholinesterase

(2018) Zrinka Kovarik et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents

(2018) Tamara Zorbaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning

(2017) Patrick Masson et al.   JOURNAL OF NEUROCHEMISTRY

New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds

(2017) Maja Katalinić et al.   MOLECULES

Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence

(2017) David Gunnell et al.   Lancet Global Health

Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6

(2016) Timo Wille et al.   ARCHIVES OF TOXICOLOGY

Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases

(2016) Nikola Maraković et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications

(2016) Yacov Ashani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structure–property relationship of quinuclidinium surfactants—Towards multifunctional biologically active molecules

(2016) Mirjana Skočibušić et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers

(2016) Maja Katalinić et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase

(2016) Michael Winter et al.   TOXICOLOGY LETTERS

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes

(2015) Zrinka Kovarik et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase

(2014) Gabriele Horn et al.   ARCHIVES OF TOXICOLOGY

Mechanochemical and Conformational Study of N-heterocyclic Carbonyl-Oxime Transformations

(2014) Ines Primožič et al.   CROATICA CHEMICA ACTA

Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification

(2014) Rakesh K. Sit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oximes as reversible links in polymer chemistry: dynamic macromolecular stars

(2014) Soma Mukherjee et al.   Polymer Chemistry

Fresh Frozen Plasma as a Successful Antidotal Supplement in Acute Organophosphate Poisoning

(2013) Slavica Vučinić et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: Possible implications for the HI-6 antidote substrate specificity

(2013) Elisabet Artursson et al.   BIOCHEMICAL PHARMACOLOGY

Progress in the development of enzyme-based nerve agent bioscavengers

(2013) Florian Nachon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Physicochemical Properties and Supernucleophilicity of Oxime-Functionalized Surfactants: Hydrolytic Catalysts toward Dephosphorylation of Di- and Triphosphate Esters

(2013) Namrata Singh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Syrian gas attack reinforces need for better anti-sarin drugs

(2013) Elie Dolgin   NATURE MEDICINE

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes

(2012) Zoran Radić et al.   BIOCHEMICAL JOURNAL

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates

(2012) Zoran Radić et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents

(2012) Julien Renou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Binding Modes of Quinuclidinium Esters to Butyrylcholinesterase

(2012) Ines Primožič et al.   CROATICA CHEMICA ACTA

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

(2011) Guillaume Mercey et al.   CHEMICAL COMMUNICATIONS

In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase)

(2011) Marco Melzer et al.   Drug Testing and Analysis

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX

(2010) Ashima Saxena et al.   BIOCHEMICAL PHARMACOLOGY

Interactions of pyridinium oximes with acetylcholinesterase

(2010) Goran Šinko et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase

(2010) Zrinka Kovarik et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Butyrylcholinesterase for protection from organophosphorus poisons: Catalytic complexities and hysteretic behavior

(2009) Patrick Masson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: A kinetic analysis

(2009) N. Aurbek et al.   TOXICOLOGY

Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases

(2008) Maja Čalić et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning

(2008) Zrinka Kovarik et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation

(2008) Eugénie Carletti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY