Article
Biochemistry & Molecular Biology
Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek
Summary: The designed and synthesised pyridinium-2-carbaldoximes with quinolinium carboxamide moiety showed intermediate-to-high inhibition of both cholinesterases compared to standard oximes. In vitro evaluation revealed their reactivation ability on human recombinant acetylcholinesterase (hrAChE) and human recombinant butyrylcholinesterase (hrBChE), with one compound showing reactivation of all used organophosphates on hrAChE, and two novel compounds able to reactivate NIMP/NEMP-hrBChE. The molecular modelling results highlighted the importance of creating a pre-reactivation complex for better reactivation of both cholinesterases.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Avinash G. Vishakantegowda, Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn, Young-Sik Jung
Summary: This study aimed to explore non-pyridinium oxime acetylcholinesterase (AChE) reactivators for the treatment of neurologic manifestations induced by organophosphorus agents. Compound 13 showed the highest reactivation of AChE and has the potential to be developed into a novel AChE reactivator that can cross the blood-brain barrier.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Toxicology
Eliska Prchalova, Zuzana Kohoutova, Karolina Knittelova, David Malinak, Kamil Musilek
Summary: Oxime reactivators are commonly used to treat organophosphate poisoning, but they have difficulty crossing the blood-brain barrier. Researchers have explored various strategies to enhance their bioavailability in the CNS, including structural modifications, conjugation with BBB transporters, intranasal delivery, and inhibition of BBB efflux transporters. The use of nanoparticles as delivery systems, such as mesoporous silica nanomaterials and poly(l-lysine)-graft-poly(ethylene oxide) NPs, has shown promising results.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Toxicology
Max Epstein, Karan Bali, Thomas J. Piggot, A. Christopher Green, Christopher M. Timperley, Mike Bird, John E. H. Tattersall, Isabel Bermudez, Philip C. Biggin
Summary: Organophosphorus nerve agents are highly toxic chemical warfare agents that have been used since the 1930s. While there are several antidotes available, none directly target the toxic component of these agents. Research shows that nonoxime bispyridinium compounds can improve detoxification effects.
TOXICOLOGY LETTERS
(2021)
Article
Medicine, Research & Experimental
Rudolf Andrys, Aneta Klusonova, Miroslav Lisa, Jiri Kassa, Jana Zd'arova Karasova
Summary: Oxime-based molecules are used to reactivate AChE function in patients with organophosphate intoxication, but their efficacy is limited by low brain penetration. In this study, the use of cucurbit[7]uril (CB[7]) as a carrier for the clinical agent asoxime significantly enhanced its bioavailability in the brain. Pharmacokinetic analysis showed over a 3-fold increase in brain activity when asoxime was administered as a complex with CB[7] compared to alone.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Nela Vanova, Anna Hojna, Jaroslav Pejchal, David Herman, David Malinak, Eliska Prchalova, Kamil Musilek, Jana Zdarova Karasova
Summary: Oxime K869 is a potent reactivator of AChE and BChE, quickly absorbed after intramuscular injection, reaching peak plasma concentration within 15-20 minutes. It is primarily eliminated via the kidneys, with only limited penetration into the brain observed 30 minutes after administration.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Toxicology
Lukas Gorecki, Vendula Hepnarova, Jana Zdarova Karasova, Martina Hrabinova, Charlotte Courageux, Jose Dias, Tomas Kucera, Tereza Kobrlova, Lubica Muckova, Lukas Prchal, David Malinak, Daniel Jun, Kamil Musilek, Franz Worek, Florian Nachon, Ondrej Soukup, Jan Korabecny
Summary: Novel monoquaternary reactivators developed in this study showed superior efficacy compared to clinically used standards, with broad-spectrum capability demonstrated in both in vitro and in vivo experiments. Through detailed investigation of their reactivation mechanisms, K1374 and K1375 emerged as promising candidates for further exploration as nerve agents and insecticide antidotes.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Lydia Gonzalez, Javier D. Martin-Romera, Purificacion Sanchez-Sanchez, Jorge A. R. Navarro, Elisa Barea, Carmen R. Maldonado, Francisco J. Carmona
Summary: A novel material combining Zr-MOF-808 and a neutral oxime RS69N was synthesized, exhibiting dual activity against organophosphate poisoning. This hybrid material showed a significant drug payload and sustained oxime release in simulated physiological media, effectively reactivating OP-inhibited acetylcholinesterase. Additionally, it demonstrated efficient and moderately fast removal of a toxic organophosphorus model compound from simulated physiological media.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bishwajit Das, Durjoy Majumder
Summary: Nerve agent poisoning remains a threat to civilization. This study uses molecular docking to compare the toxicity of different nerve agents and the effectiveness of different antidote drugs, finding that VX is the most harmful nerve agent and HI-6 is the best drug for prevention.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Cecilia Lindgren, Nina Forsgren, Norman Hoster, Christine Akfur, Elisabet Artursson, Lotta Edvinsson, Richard Svensson, Franz Worek, Fredrik Ekstrom, Anna Linusson
Summary: This article introduces new strategies and tools for developing reactivators. By studying the non-covalent interactions with OPNA-AChEs, suitable inhibitor scaffolds are converted into broad-spectrum reactivators. Determinants of reactivation efficiency are identified through analysis of reactivation and pre-reactivation kinetics and structural data.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Analytical
Sheng-Song Li, Yong-Chao Zheng, Xiao-Ming Zhu, Hong-Bo Wang, Long-Hui Liang, Xu-Zhe Wang, Ling Yuan, Fa-Heng Zhang, He Zheng, Chong-Lin Zhao
Summary: A fluorescent BODIPY probe was designed and synthesized for highly sensitive and selective detection of DCNP, showing significant fluorescence quenching in the presence of Et3N and a 30-fold fluorescence enhancement in the presence of DCNP. The fluorescence variations were attributed to intramolecular photo-induced electron transfer process, with a low limit of detection (34 nM) and rapid response (t1/2 = 175 s). Naked-eye detection of DCNP was also achieved in both liquid and vapor phases using test strips immobilized with the probe.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Goran Sinko
Summary: Currently, only four antidotes are available for treating poisoning by organophosphorus compounds. Many newly designed compounds fail at the enzyme level due to unfavorable interactions within the active site, hindering successful reactivation. Modeling a phosphorylated oxime (POX) can help understand the role of active site residues in the formation of a Michaelis-type complex. Molecular dynamics was used to test the stability of the oxime near the phosphorylated serine in order to study interactions between the AChE oxyanion hole and the phosphorylated oxime.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Nanoscience & Nanotechnology
Priyanka Biswas, Dylan B. Shuster, Busra Sonmez Baghirzade, Randall A. Scanga, Sophie A. Harris, Cynthia N. Tran, Onur G. Apul, James F. Reuther
Summary: In this study, novel oxime-functionalized poly(4-vinylpyridine) (P4VP-Ox) materials were developed as inexpensive and scalable polymeric substrates for the rapid decontamination of nerve agents. Nanofibers obtained from P4VP functionalized at 20 mol % pendants with ortho-pyridinium oximes moieties provided the fastest reaction kinetics, achieving complete decomposition of DMNP within 1.5 h. The P4VP-Ox substrates were also found to be recyclable, allowing for quantitative DMNP degradation within 8 h over the course of four reaction cycles.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Kamil Kuca, Jorge Alberto Valle da Silva, Eugenie Nepovimova, Ngoc Lam Pham, Wenda Wu, Martin Valis, Qinghua Wu, Tanos Celmar Costa Franca
Summary: This study examined a derivative of 2-PAM with enhanced lipophilicity as a potential brain-penetrating AChE reactivator. However, the structural modification resulted in decreased reactivation efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Lukas Gorecki, Ondrej Soukup, Jan Korabecny
Summary: Nerve agents are highly toxic chemical weapons with fast action and simple synthesis. The current medical intervention methods have limitations and further research is needed.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina A. Oliva, Elena Sanchez-Lopez, Miren Ettcheto, Manuela Bartolini, Angela De Simone, Mattia Ricchini, Marisa Rendina, Megane Pons, Omidreza Firuzi, Belen Perez, Luciano Saso, Vincenza Andrisano, Florian Nachon, Xavier Brazzolotto, Maria Luisa Garcia, Antoni Camins, Israel Silman, Ludovic Jean, Nibaldo C. Inestrosa, Jacques-Philippe Colletier, Pierre-Yves Renard, Diego Munoz-Torrero
Summary: By combining the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin, compounds with nanomolar potencies towards AChE and BChE were created, demonstrating potential therapeutic effects for Alzheimer's disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Quentin Ibert, Madeleine Cauwel, Thomas Glachet, Tony Tite, Patricia Le Nahenec-Martel, Jean-Francois Lohier, Pierre-Yves Renard, Xavier Franck, Vincent Reboul, Cyrille Sabot
Summary: Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. The methods are operationally simple, and tolerant to most functional groups, providing diazirines with yields ranging from 20 to 99%.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Medicinal
Ophelie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, Andre-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilene Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, Jose Dias
Summary: Recent events have highlighted the serious threat posed by organophosphorus nerve agents to civilian and military populations. This study proposes the use of glucoconjugated oximes without permanent charge as potential central nervous system reactivators, aiming to overcome the current limitations in therapy. The study evaluates the effectiveness of these compounds, their structural characteristics, and their permeability through the blood-brain barrier.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Alexis Lossouarn, Chloe Puteaux, Laetitia Bailly, Vincent Tognetti, Laurent Joubert, Pierre-Yves Renard, Cyrille Sabot
Summary: This study reports a protein-directed synthesis method for synthesizing carbonic anhydrase inhibitors and discovers unexpected photophysical properties. Fine-tuning of substituents on the coumarin moiety allows for bidirectional photochemical reactions, leading to the discovery of a new photoswitch moiety with fluorescence properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Organic
Kevin Renault, Pierre-Yves Renard, Cyrille Sabot
Summary: This review provides an overview of the synthesis of quinoxalin-2(1H)-ones and discusses their fluorescence properties and applications, including chemosensing and biosensing.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Steven Vertueux, Alexandre Haefele, Kathleen Solmont, Philippe Durand, Pierre-Yves Renard
Summary: A series of chemiluminescent cassettes based on adamantyl stabilized 1,2-dioxetanes linked to a fluorophore by a conjugated linker were synthesized in this study. The chemiluminescent decomposition and photoluminescence properties of their respective emissive species were investigated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Steve Saulnier, Nawel Mehiaoui, Stephane Leleu, Ludovic Jean
Summary: This article introduces a reliable but little-explored method for the amine-promoted rearrangement of 3-halogenated and 3-tosylated flavones into amino-substituted aurones in aurone synthesis. The researchers extended this method to 8-azaflavones, which were readily prepared from 3-cyano-2-pyridones by the Baker-Venkataraman methodology. They found that under mild conditions and in the presence of a broad range of aliphatic primary and secondary amines, including bulky amines, the 8-azaflavones rearrange into 7-azaaurones, overcoming steric hindrance issues by Lewis base organocatalysis.
Article
Chemistry, Multidisciplinary
Aurelie Gernet, Ahmed El Rhaz, Ludovic Jean
Summary: Thioaurone chromophores, also known as hemithioindigos, have attracted attention due to their interesting photoswitching properties. This study focuses on heterocyclic hemithioindigos (Het-HTIs) and investigates their synthesis and photoswitching performances. The influence of heterocycles on the photoisomerization capabilities was found to be more prominent than the modifications to the thioindigo moiety. Several Het-HTIs demonstrated highly efficient photoswitchable properties, making them promising candidates for light-controlled molecular mechanisms.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Maxime Boddaert, Pauline Bianchi, Diana V. Silva-Brenes, Ancuta Musina, Marc Winter, Philippe M. C. Roth, Pierre-Yves Renard, Julien Legros, Jean-Christophe M. Monbaliu
Summary: This study introduces a new, efficient, safe, and sustainable flow protocol using ozone to oxidatively neutralize sulfur-based chemical warfare agent simulants. The combination of computational research and experimental validation has successfully achieved rapid neutralization under flow conditions.
Article
Chemistry, Multidisciplinary
Sergui Mansour, Antonin Delaune, Maxime Manneveau, Baptiste Picard, Amelie Claudel, Cecile Vallieres, Lea Sigot, Pierre-Yves Renard, Julien Legros
Summary: This study found that the neutralisation of a simulant of the chemical warfare agent VX can be effectively carried out with lithium ethanolate in a nylon custom printed flow reactor. The formation of EtOLi and the neutralisation can be completed in a single operation. Additionally, the robustness and recyclability of the device were demonstrated.
Article
Chemistry, Multidisciplinary
Antonin Delaune, Sergui Mansour, Baptiste Picard, Philippe Carrasqueira, Isabelle Chataigner, Ludovic Jean, Pierre-Yves Renard, Jean-Christophe M. Monbaliu, Julien Legros
Summary: The oxidative neutralisation of sulfur-containing CWAs with Oxone in flow systems has been developed, and in order to achieve full selectivity towards harmless decomposition products, Oxone must be used in either solid or aqueous form.
Article
Chemistry, Multidisciplinary
Madeleine Cauwel, Clement Guillou, Kevin Renault, Damien Schapman, Magalie Benard, Ludovic Galas, Pascal Cosette, Pierre-Yves Renard, Cyrille Sabot
Summary: This study presents a novel photoaffinity probe based on quinoxalinone, which can covalently capture proteins and label them with fluorescence under visible blue LED irradiation (max wavelength 450 nm). This process allows monitoring applications without the need for washing.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)