Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells

(2020) Anne-Cathrin Behr et al.   ARCHIVES OF TOXICOLOGY

Dose effects of ammonium perfluorooctanoate on lipoprotein metabolism in APOE*3-Leiden.CETP mice

(2019) Marianne G Pouwer et al.   TOXICOLOGICAL SCIENCES

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells

(2019) Leonore Wigger et al.   PLoS One

SPPARM alpha

(2019) Jean-Charles Fruchart et al.   CURRENT OPINION IN LIPIDOLOGY

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells

(2018) Yan Xin et al.   ARCHIVES OF TOXICOLOGY

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

(2018) Matteo Convertino et al.   TOXICOLOGICAL SCIENCES

Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro

(2018) Anne-Cathrin Behr et al.   TOXICOLOGY LETTERS

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

(2018) Russell A. DeBose-Boyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?

(2017) Zhanyun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

(2015) Shengmin Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of polyfluoroalkyl chemical exposure with serum lipids in children

(2015) Xiao-Wen Zeng et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation

(2014) Cynthia J. Wolf et al.   TOXICOLOGY

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

(2013) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population

(2013) Kirsten T. Eriksen et al.   PLoS One

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Perfluoroalkyl Sulfonates Cause Alkyl Chain Length–Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice

(2011) Silvia Bijland et al.   TOXICOLOGICAL SCIENCES

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ConsensusPathDB: toward a more complete picture of cell biology

(2010) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant

(2009) K. Steenland et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population

(2009) Jessica W. Nelson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Glyceroneogenesis Is the Dominant Pathway for Triglyceride Glycerol Synthesisin Vivoin the Rat

(2008) Colleen K. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Separation of cellular nonpolar neutral lipids by normal-phase chromatography and analysis by electrospray ionization mass spectrometry

(2008) Patrick M. Hutchins et al.   JOURNAL OF LIPID RESEARCH