Review
Oncology
Zixi Hong, Zimeng Wei, Tian Xie, Lin Fu, Jiaxing Sun, Fuling Zhou, Muhammad Jamal, Qiuping Zhang, Liang Shao
Summary: Acute lymphoblastic leukemia (ALL) is regulated by various signaling molecules such as cytokines and adhesion molecules in its microenvironment. Chemokines play important roles in leukemia microenvironment and affect ALL outcomes. Targeting chemokine axes for ALL treatments shows potential, with some related inhibitors entering clinical trials.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Hematology
Sofie Gottschalk Hojfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G. Jonsson, Thomas L. Frandsen, Benjamin O. Wolthers, Hanne Vibeke Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen
Summary: Truncation of asparaginase treatment due to toxicity or silent inactivation may increase relapse risk in children with acute lymphoblastic leukemia, highlighting the importance of therapeutic drug monitoring and appropriate adjustment of therapy.
Article
Biochemistry & Molecular Biology
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano
Summary: Chemokines have local functions in controlling leukocyte extravasation and also play additional roles in regulating hematopoiesis and leukocyte differentiation at a systemic level. Atypical chemokine receptors (ACKRs) are regulators of the chemokine system and have a selective role in neutrophil production and differentiation. This review provides an overview of the role of chemokines and chemokine receptors in neutrophil biology with a focus on the regulation exerted by ACKRs.
Article
Immunology
Dominic D. Skinner, Amber R. Syage, Gema M. Olivarria, Colleen Stone, Bailey Hoglin, Thomas E. Lane
Summary: By characterizing the molecular and cellular changes in transgenic mice, this study reveals the changes in the profile of neutrophils associated with increased white matter damage in mice persistently infected with a neurotropic coronavirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ibrahim Aldoss, Salman Otoukesh, Jianying Zhang, Sally Mokhtari, Dat Ngo, Mona Mojtahedzadeh, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Paul Koller, Brian Ball, Forrest Stewart, Peter Curtin, Andrew Artz, Ryotaro Nakamura, Guido Marcucci, Stephen J. Forman, Anthony S. Stein, Vinod Pullarkat
Summary: Blintumomab shows promising activity in relapsed/refractory acute lymphoblastic leukemia (ALL) patients, but there are risk factors for treatment failure, particularly extramedullary relapse and retention of CD19 expression.
Article
Oncology
Austin L. Brown, Kimberly P. Raghubar, Olga A. Taylor, Melanie Brooke Bernhardt, Lisa S. Kahalley, Wei Pan, Philip J. Lupo, Marilyn J. Hockenberry, Michael E. Scheurer
Summary: Research on pediatric acute lymphoblastic leukemia (ALL) patients found that symptoms such as fatigue, pain, nausea, and sleep disturbances at specific treatment stages were associated with subsequent relapse. This suggests that patient-reported symptoms could serve as prognostic indicators for identifying high-risk pediatric ALL patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, Research & Experimental
Xueliang Gao, Shenghui Qin, Yongxia Wu, Chen Chu, Baishan Jiang, Roger H. Johnson, Dong Kuang, Jie Zhang, Xi Wang, Anand Mehta, Kenneth D. Tew, Gustavo W. Leone, Xue-Zhong Yu, Haizhen Wang
Summary: PFKP, the major isoform of PFK1 in T-ALL, functions as a nucleocytoplasmic shuttling protein with nuclear export and localization sequences. Nuclear PFKP promotes the expression of CXCR4 to facilitate T-ALL cell invasion, which can be blocked with CXCR4 antagonists. The presence of nuclear PFKP in T cell malignancy correlates with poor survival and suggests its potential as a diagnostic marker.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Eulalia Genesca, Celia Gonzalez-Gil
Summary: Thanks to high-resolution genetic techniques, we now have a clearer understanding of the genetic landscape in T-ALL and have begun to understand relapse-specific mechanisms. This review summarizes the latest advances in our knowledge of the genome in T-ALL and highlights the areas where research in this ALL subtype is progressing.
Article
Medicine, General & Internal
Andrej Lissat, Claudia van Schewick, Ingo G. Steffen, Ayumu Arakawa, Jean-Pierre Bourquin, Birgit Burkhardt, Guenter Henze, Georg Mann, Christina Peters, Lucie Sramkova, Cornelia Eckert, Arend von Stackelberg, Christiane Chen-Santel
Summary: The study focused on children with extramedullary relapse of acute lymphoblastic leukemia, identifying specific clinical features and poor prognosis. Individualized treatment based on patient-specific factors is necessary, and localized therapy may be beneficial in selected cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Andrea Bonnin Marquez, Emiel P. C. van der Vorst, Sanne L. Maas
Summary: Atherosclerosis is a major cause of cardiovascular diseases, and chemokines and their receptors play a crucial role in its pathophysiological development. Targeting these factors through various methods shows promise in ameliorating atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Oncology
David O'Connor, Jonas Demeulemeester, Lucia Conde, Amy Kirkwood, Kent Fung, Foteini Papaleonidopoulou, Gianna Bloye, Nadine Farah, Sunniyat Rahman, Jeremy Hancock, Caroline Bateman, Sarah Inglott, Jon Mee, Javier Herrero, Peter Van Loo, Anthony V. Moorman, Ajay Vora, Marc R. Mansour
Summary: Failure to respond to induction chemotherapy is associated with poor outcome in childhood acute lymphoblastic leukemia (ALL) , especially in T-cell ALL (T-ALL). This study aimed to investigate clinical and genetic factors that influence outcome in T-ALL induction failure (IF). The study found that IF occurred in 10.3% of cases, with increasing age being a risk factor. The overall survival rate was significantly lower in IF patients compared to responsive patients. Genomic profiling revealed that TAL1 noncoding mutations were associated with poor prognosis.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marcela B. Mansur, Caroline L. Furness, Sirintra Nakjang, Amir Enshaei, Donat Alpar, Sue M. Colman, Lynne Minto, Julie Irving, Beth V. Poole, Elda P. Noronha, Suvi Savola, Sameena Iqbal, John Gribben, Maria S. Pombo-de-Oliveira, Tony M. Ford, Mel F. Greaves, Frederik W. van Delft
Summary: The study found that adolescent and young adult T-ALL does not have specific genetic abnormalities compared to pediatric or adult T-ALL, showing a transitional genomic profile.
Article
Mathematics
Miguel Gonzalez, Cristina Gutierrez, Rodrigo Martinez
Summary: A two-type two-sex branching process is used to model the evolution of carriers and mutations of a Y-linked gene, with limiting growth rates of couples and males on different genotype sets obtained. Results are illustrated through simulated studies contextualized in problems of population genetics.
Article
Oncology
Odelaisy Leon-Triana, Antonio Perez-Martinez, Manuel Ramirez-Orellana, Victor M. Perez-Garcia
Summary: CAR-T cell-based therapies have shown success in hematological malignancies but have been limited in solid tumors due to the immunosuppressive tumor microenvironment. A mathematical model in this paper suggests that targeting solid tumor antigens with large numbers of CAR-T cells could overcome this immunosuppression, potentially leading to successful treatments. Computer simulations indicate that the strategy of utilizing CAR-T cells targeting multiple antigens may lead to the expansion of a strong army of CAR-T cells in solid tumors. This proposed approach could provide a promising avenue for overcoming the immune suppression and achieving successful CAR-T cell therapies against solid tumors.
Article
Biochemical Research Methods
Miguel Gonzalez, Cristina Gutierrez, Rodrigo Martinez
Summary: The study analyzes the evolution of Y-linked allele carriers and mutations using a Y-linked two-sex branching process model, estimating main parameters through Bayesian inference. By observing total number of females, males, males of each genotype in last generation, and introducing information on mutated males in last generation, the study approximates the posterior distributions of model parameters using Approximate Bayesian Computation (ABC). Illustrations and discussion on accuracy of the procedure based on simulated examples are provided.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Martinez-Rubio, Salvador Chulian, Cristina Blazquez Goni, Manuel Ramirez Orellana, Antonio Perez Martinez, Alfonso Navarro-Zapata, Cristina Ferreras, Victor M. Perez-Garcia, Maria Rosa
Summary: CAR T-cell therapy shows high response rates in treating B-cell Acute Lymphoblastic Leukemia, but relapse can still occur. The status of CAR T cells in bone marrow plays a key role in treatment response. A mathematical model depicting interactions between different cell populations is essential in understanding the causes of treatment resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Maria Vinaixa, Sandra Canelles, Africa Gonzalez-Murillo, Vitor Ferreira, Diana Grajales, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Manuel Ramirez-Orellana, Oscar Yanes, Laura M. Frago, Angela M. Valverde, Vicente Barrios
Summary: The research found that non-diabetic IRS2(-/-) mice exhibited elevated anti-inflammatory cytokines in the hypothalamus, while diabetic IRS2(-/-) mice displayed a proinflammatory profile. Additionally, non-diabetic mice showed increased enzyme activity, enhanced lipid synthesis, and elevated levels of polyunsaturated fatty acids.
Article
Oncology
Belen Lopez-Millan, Paula Costales, Francisco Gutierrez-Aguera, Rafael Diaz de la Guardia, Heleia Roca-Ho, Meritxell Vinyoles, Alba Rubio-Gayarre, Remi Safi, Julio Castano, Paola Alejandra Romecin, Manuel Ramirez-Orellana, Eduardo Anguita, Irmela Jeremias, Lurdes Zamora, Juan Carlos Rodriguez-Manzaneque, Clara Bueno, Francisco Moris, Pablo Menendez
Summary: The study found that EC-70124 is a promising and safe agent for the treatment of FLT3-ITDMUT AML, exhibiting robust and specific antileukemia activity while sparing healthy hematopoietic cells.
Article
Mathematics
Miguel Gonzalezna, Carmen Minuesa, Ines del Puertona
Summary: This paper proposes a method for estimating the posterior distribution of the parameters of controlled branching processes without prior knowledge, and applies it to simulated and real datasets to verify its accuracy and feasibility.
REVISTA DE LA REAL ACADEMIA DE CIENCIAS EXACTAS FISICAS Y NATURALES SERIE A-MATEMATICAS
(2022)
Article
Statistics & Probability
Miguel Gonzalez, Pedro Martin-Chavez, Ines M. del Puerto
Summary: The article aims to provide a Feller diffusion approximation for critical controlled branching processes (CBPs). A similar result has been previously proved by considering a fixed number of initial individuals using operator semigroup convergence theorems. An alternative proof is now provided using limit theorems for random step processes.
Article
Chemistry, Medicinal
Laura Gonzalez-Cofrade, Irene Cuadrado, Angel Amesty, Ana Estevez-Braun, Beatriz de las Heras, Sonsoles Hortelano
Summary: The study demonstrates that DIH effectively inhibits NLRP3 inflammasome activation in macrophages, showing potential application in treating inflammation-related diseases.
Article
Chemistry, Medicinal
Irene Cuadrado, Sandra Oramas-Royo, Laura Gonzalez-Cofrade, Angel Amesty, Sonsoles Hortelano, Ana Estevez-Braun, Beatriz de las Heras
Summary: A series of new labdane conjugates were synthesized and showed cardioprotective effects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress-mediated signaling pathways and autophagy mediated by Akt activation.
DRUG DEVELOPMENT RESEARCH
(2023)
Letter
Statistics & Probability
M. Gonzalez, M. Molina, I. del Puerto
Article
Biochemistry & Molecular Biology
Laura Gonzalez-Cofrade, Jack P. Green, Irene Cuadrado, Angel Amesty, Sandra Oramas-Royo, David Brough, Ana Estevez-Braun, Sonsoles Hortelano, Beatriz de las Heras
Summary: This study evaluated the potential anti-inflammatory activity of phenolic and quinonemethide nor-triterpenes isolated from Maytenus retusa and their derivatives through inhibition of the NLRP3 inflammasome. Triterpenes 6 and 14 showed the highest anti-inflammatory activity by significantly reducing caspase-1 activity, IL-1 beta secretion, and pyroptosis. Further characterization confirmed their selective inhibition of NLRP3 inflammasome without affecting AIM2 or NLRC4 inflammasome activation.
BIOORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Pedro Martin-Acosta, Irene Cuadrado, Laura Gonzalez-Cofrade, Roberto Pestano, Sonsoles Hortelano, Beatriz de las Heras, Ana Estevez-Braun
Summary: A set of new dihydroquinoline embelin derivatives were synthesized from the reaction of natural benzoquinone embelin with anilines and aromatic aldehydes in the presence of AgOTf. The resulting compounds showed potential as cardioprotective agents, attenuating the cardiotoxicity effect of doxorubicin on oxidative stress and apoptosis. The best activities were achieved with quinoline-embelin derivatives having a 4-nitrophenyl group attached at the pyridine ring.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biology
Andrea Perez-Montero, Oscar Zaragoza, Alfonso Luque, Sonsoles Hortelano, Paloma Acebo
Summary: Lipid droplets (LD) are important lipid storage organelles with multiple biological functions. Fluorescence imaging is commonly used to visualize LD, but it can cause damage and alter organelle dynamics. This study presents a label-free method using 3D holotomographic microscopy to visualize LD accumulation in MH-S alveolar macrophages treated with oleic acid.
Meeting Abstract
Respiratory System
S. Barril, D. Castillo, P. Millan, A. Luque, P. Acebo, S. Hortelano
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Hematology
Fanbi Meng, Shuang Chen, Chunliang Liu, Muhammad Shoaib Khan, Yan Yan, Jun Wan, Yue Xia, Chenglin Sun, Mengnan Yang, Renping Hu, Kesheng Dai
Summary: PKC plays a critical role in regulating megakaryocyte development and platelet production in thrombocytopenia. The inhibition of PKC activation delays and reduces radiation-induced megakaryocyte apoptosis, leading to improved platelet count recovery. This study provides a potential therapeutic target for treating thrombocytopenia.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Xia Chen, Fang Liu, Yuanyuan Ren, Luyang Zhang, Yang Wan, Wenyu Yang, Xiaojuan Chen, Li Zhang, Yao Zou, Yumei Chen, Xiaofan Zhu, Ye Guo
Summary: Unrelated umbilical cord blood transplantation (UCBT) is an effective alternative treatment for pediatric patients with bone marrow failure. The use of the TBI/BU + FLU + CY conditioning regimen ensures a high engraftment rate for UCBT and overcomes the challenge of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Chithra D. Palani, Xingguo Zhu, Manickam Alagar, Otis C. Attucks, Betty S. Pace
Summary: This study evaluated the ability of a novel Bach1 inhibitor, HPP-D, to induce HbF in KU812 cells and primary sickle erythroid progenitors. The results showed that HPP-D increased HbF levels and decreased Bach1 protein levels in both cell types. Furthermore, it enhanced NRF2 binding to the gamma-globin promoter antioxidant response elements, leading to an open chromatin configuration and increased gamma-globin transcription.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Letter
Hematology
Marcos Borato Viana, Erica Louback Oliveira, Andre Rolim Belisario
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Ke Zhang, Longying Ye, Yanhui Jin, Yuan Chen, Shuting Jiang, Haixiao Xie, Lihong Yang, Mingshan Wang
Summary: This study investigated two pedigrees with FV deficiency and identified three mutations that may have deleterious effects on the function and structure of FV.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
