Review
Immunology
YiFan Zhao, RuiTing Guo, XinPing Cao, Yi Zhang, Rui Sun, WenYi Lu, MingFeng Zhao
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a highly heterogeneous and aggressive hematologic malignancy, with limited therapeutic options. Targeted therapies aimed at specific molecular pathways have shown potential in improving patient outcomes. Chemokine-related signals play crucial roles in T-ALL pathogenesis by modulating tumor microenvironments and cellular processes. This review explores the advantages and disadvantages of current and potential therapeutic options targeting chemokine axes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Charlise Basson, June Cheptoo Serem, Priyesh Bipath, Yvette Nkondo Hlophe
Summary: This article discusses the pathological characteristics of cutaneous melanoma, which is becoming increasingly prevalent, as well as the use of chemotherapy in the treatment of cutaneous melanoma. It is found that the activation of chemokine axes plays an important role in the metastasis of melanoma, so intervention targeting these axes can be considered in the treatment of melanoma. Experimental results have shown that targeting chemokine axes can inhibit the migration, proliferation, and survival of tumor cells, thereby slowing down the metastasis and progression of melanoma.
Article
Oncology
Jonathan Tucci, Ting Chen, Katherine Margulis, Etan Orgel, Rebecca L. Paszkiewicz, Michael D. Cohen, Matthew J. Oberley, Rachel Wahhab, Anthony E. Jones, Ajit S. Divakaruni, Cheng-Chih Hsu, Sarah E. Noll, Xia Sheng, Richard N. Zare, Steven D. Mittelman
Summary: The study found that adipocytes release free fatty acids in the presence of acute lymphoblastic leukemia cells, which are taken up by the leukemia cells and incorporated into triglycerides and phospholipids. Adipocyte-derived lipids can relieve ALL cell endogenous lipogenesis and reverse the cytotoxicity of chemotherapy, altering cell metabolism from glucose to fatty acid oxidation. Targeting lipid synthesis and metabolism may potentially reverse adipocyte protection of ALL cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qianling Xin, Zhaoying Chen, Wei Wei, Yujing Wu
Summary: Acute lymphoblastic leukemia (ALL) is a highly aggressive hematologic tumor with poor prognosis and limited effective drugs. Understanding its pathogenesis is important for discovering potential therapeutic drugs and treatment targets. Animal models provide a valuable tool to study the complex mechanisms of ALL, evaluate new drugs and treatment approaches, and assess potential adverse reactions on healthy organs. This article reviews the progression of ALL animal models, with a focus on mouse models that closely resemble the human phenotype. The advantages and limitations of each model are summarized, facilitating a better understanding of the etiology of ALL and contributing to effective disease management.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Sreoshee Rafiq, Sharon L. McKenna, Sylviane Muller, Mario P. Tschan, Magali Humbert
Summary: Lysosomes, traditionally known for degrading cellular macromolecules, have emerged as crucial regulators of cell homeostasis. Their involvement in cellular trafficking, nutrient signaling, energy metabolism, and immune regulation has sparked interest in targeting lysosomes for novel disease treatments, particularly cancer. This review highlights the diverse functions of lysosomes and their importance in malignant disease, with a focus on potential targeting strategies in acute myeloid leukemia (AML).
Article
Oncology
Xuezhi Zhou, Manjuan Peng, Ye He, Jingjie Peng, Xuan Zhang, Chao Wang, Xiaobo Xia, Weitao Song
Summary: CXC chemokines play an important role in SKCM and are closely related to patient prognosis. Our research provides a basis for screening SKCM biomarkers, predicting prognosis, and choosing immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhongyi Jiang, Changchang Xing, Pusen Wang, Xueni Liu, Lin Zhong
Summary: This study revealed that transcriptional levels of multiple chemokines CCL were elevated in LIHC tissues and closely associated with disease progression and patient prognosis. Key transcription factors and immune cell infiltration were also correlated with CCL expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jennifer L. Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W. Lam, Elizabeth A. R. Garfinkle, Pratima Nallagatla, Amelia M. R. Smith, Sharnise Mitchell, Jing Ma, Duane Currier, William C. Wright, Kanisha Kavdia, Vishwajeeth R. Pagala, Wonil Kim, LaShanale M. Wallace, Ji-Hoon Cho, Yiping Fan, Aman Seth, Nathaniel Twarog, John K. Choi, Esther A. Obeng, Mark E. Hatley, Monika L. Metzger, Hiroto Inaba, Sima Jeha, Jeffrey E. Rubnitz, Junmin Peng, Taosheng Chen, Anang A. Shelat, R. Kiplin Guy, Tanja A. Gruber
Summary: Proteasome inhibition is found to be effective in KMT2Ar infant acute lymphoblastic leukemia, leading to the depletion of histone modifications and downregulation of KMT2A gene expression signature. A cohort of relapsed/refractory KMT2Ar patients treated with this approach showed a high overall response rate. This innovative treatment approach is now being evaluated in a multi-institutional upfront trial for infants with newly diagnosed ALL.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Anastasia M. M. Hughes, Vincent Kuek, Joyce Oommen, Grace-Alyssa Chua, Maria van Loenhout, Sebastien Malinge, Rishi S. S. Kotecha, Laurence C. C. Cheung
Summary: Components of the bone marrow microenvironment (BMM) play a significant role in the development, progression, and treatment response of acute lymphoblastic leukemia (B-ALL). This study investigated the cellular and transcriptome profiles of mesenchymal stem cells (MSCs) isolated from the BMM of an immunocompetent BCR-ABL1(+) model of B-ALL. The findings showed that leukemia-associated MSCs had reduced self-renewal capacity, upregulation of inflammatory signaling pathways, and downregulation of genes involved in extracellular matrix organization and osteoblastogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xueliang Gao, Shenghui Qin, Yongxia Wu, Chen Chu, Baishan Jiang, Roger H. Johnson, Dong Kuang, Jie Zhang, Xi Wang, Anand Mehta, Kenneth D. Tew, Gustavo W. Leone, Xue-Zhong Yu, Haizhen Wang
Summary: PFKP, the major isoform of PFK1 in T-ALL, functions as a nucleocytoplasmic shuttling protein with nuclear export and localization sequences. Nuclear PFKP promotes the expression of CXCR4 to facilitate T-ALL cell invasion, which can be blocked with CXCR4 antagonists. The presence of nuclear PFKP in T cell malignancy correlates with poor survival and suggests its potential as a diagnostic marker.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Ilaria Iacobucci, Shunsuke Kimura, Charles G. Mullighan
Summary: Acute lymphoblastic leukemia (ALL) has achieved cure rates exceeding 90% in children, but remains a leading cause of cancer-related death in the young. Next generation sequencing has led to significant advances in understanding leukemogenesis and the development of novel therapeutic approaches, including mutation-specific and mutation-agnostic treatments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Weina Kong, Gang Zhao, Haixia Chen, Weina Wang, Xiaoqian Shang, Qiannan Sun, Fan Guo, Xiumin Ma
Summary: In this study, the role of CXC chemokines in the tumor microenvironment of cervical cancer was investigated using public databases. It was found that transcriptional levels of certain CXC chemokines were significantly altered in CC tissues, with some showing associations with patient overall survival. The study provides insights into the potential use of CXC chemokines as immunotherapeutic targets and prognostic biomarkers for cervical cancer.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Erica Dander, Chiara Palmi, Giovanna D'Amico, Giovanni Cazzaniga
Summary: Genetic lesions predisposing to pediatric B-ALL can lead to a clinically silent pre-leukemic phase. Inflammation in the microenvironment is crucial for promoting genetic instability and disease manifestation. Interaction between leukemic cells and the surrounding microenvironment influences leukemia development, chemoresistance, and other properties, highlighting the importance of a dual targeting therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Review
Hematology
Sushanta Kumar Mishra, Scott E. Millman, Lingbo Zhang
Summary: Metabolic rewiring and cellular reprogramming are characteristic features of neoplastic initiation and progression in AML. Targeting abnormal metabolic activities provides therapeutic opportunities with improved efficacy and wider therapeutic windows.
Review
Oncology
Tian Xie, Shan Pan, Hang Zheng, Zilv Luo, Kingsley M. Tembo, Muhammad Jamal, Zhongyang Yu, Yao Yu, Jing Xia, Qian Yin, Meng Wang, Wen Yuan, Qiuping Zhang, Jie Xiong
CANCER CELL INTERNATIONAL
(2018)
Article
Oncology
Meng Wang, Tian Xie, Yingjie Wu, Qian Yin, Songping Xie, Qingyu Yao, Jie Xiong, Qiuping Zhang
Article
Biochemistry & Molecular Biology
Yingjie Wu, Shan Pan, Jun Leng, Tian Xie, Muhammad Jamal, Qian Yin, Jingyuan Li, Chunjiang He, Xin Dong, Liang Shao, Qiuping Zhang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Oncology
Yingjie Wu, Muhammad Jamal, Tian Xie, Jiaxing Sun, Tianbao Song, Qian Yin, Jingyuan Li, Shan Pan, Xingruo Zeng, Songping Xie, Qiuping Zhang
Article
Oncology
Meng Wang, Songping Xie, Wen Yuan, Tian Xie, Muhammad Jamal, Jie Huang, Qian Yin, Hengya Song, Qiuping Zhang
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Review
Oncology
Muhammad Jamal, Tianbao Song, Bei Chen, Muhammad Faisal, Zixi Hong, Tian Xie, Yingjie Wu, Shan Pan, Qian Yin, Liang Shao, Qiuping Zhang
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Jiaxing Sun, Tian Xie, Muhammad Jamal, Zhenbo Tu, Xinran Li, Yingjie Wu, Jingyuan Li, Qiuping Zhang, Xiaoxing Huang
CANCER CELL INTERNATIONAL
(2020)
Article
Microbiology
Yingjie Wu, Xiaoxing Huang, Jiaxing Sun, Tian Xie, Yufei Lei, Jama Muhammad, Xinran Li, Xingruo Zeng, Fuling Zhou, Hong Qin, Liang Shao, Qiuping Zhang
Article
Emergency Medicine
Wei Xia, Lin Fu, Haihan Liao, Chan Yang, Haipeng Guo, Zhouyan Bian
JOURNAL OF EMERGENCY NURSING
(2020)
Review
Neurosciences
Wendi Pei, Lin Fu, Shui-Qing Li, Yang Yu
Summary: This review summarizes the applications of transcriptomics in nonhuman primate brain studies, including investigations of brain development, aging, toxic effects and diseases. Transcriptomics, as a powerful tool with developmental potential, has been widely utilized in neuroscience.
NEUROSCIENCE LETTERS
(2021)
Review
Genetics & Heredity
Lin Fu, Yu-Xin Luo, Ying Liu, Hui Liu, Hong-zhen Li, Yang Yu
Summary: Research has shown that changes and functions of mitochondrial DNA play a crucial role in gamete quality and fertility during gametogenesis and fertilization. Breakthroughs in mitochondrial genome editing offer great potential for the treatment of diseases related to mtDNA mutations.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Jingyuan Li, Jamal Muhammad, Tian Xie, Jiaxing Sun, Yufei Lei, Zimeng Wei, Shan Pan, Hong Qin, Liang Shao, Daozi Jiang, Qiuping Zhang
Summary: This study identified a negative correlation between LINC00853 and CCR9 expression in T-ALL, with LINC00853 suppressing cell migration and invasion by regulating the CCR9/CCL25 pathway.
MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Muhammad Jamal, Hina Iqbal Bangash, Maria Habiba, Yufei Lei, Tian Xie, Jiaxing Sun, Zimeng Wei, Zixi Hong, Liang Shao, Qiuping Zhang
Summary: COVID-19, caused by the novel coronavirus, has led to a global public health crisis with significant confirmed cases and mortalities. Patients exhibit a dysregulated immune response characterized by cytokine storm, increasing the mortality rate. Treatment strategies should focus on antiviral drugs, immunomodulators, and addressing underlying comorbidities.